PACK-CXL proved effective as a treatment for infectious keratitis in a series of patients with large, central corneal ulcers not responding to antimicrobial treatment.
PACK, which stands for photoactivated chromophore for keratitis, consists of the application of corneal cross-linking (CXL) to cases with severe infectious keratitis. The study included 18 consecutive eyes of 18 patients with severe infectious keratitis, previously and unsuccessfully treated with fortified antibiotic therapy.
The procedure was performed in the OR after the application of topical anesthesia. The epithelium was
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