Xipere, an investigational treatment for retinal vein occlusion, did not achieve its phase 3 clinical trial primary endpoint, Clearside Biomedical announced in a press release.
The multicenter, multi-country, randomized, masked phase 3 SAPPHIRE trial compared Xipere — formerly called suprachoroidal CLS-TA, a proprietary suspension of triamcinolone acetonide — used together with intravitreal Eylea (aflibercept, Regeneron) to Eylea monotherapy.
A similar proportion of patients in both arms of the trial gained at least 15 ETDRS letters in best corrected visual acuity after 8 weeks,
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