Reflex tears may provide biomarker for Parkinson’s disease

VANCOUVER, British Columbia — Researchers saw changes in oligomeric alpha-synuclein in both basal and reflex tears in patients with Parkinson’s disease, according to a study presented here at the Association for Research in Vision and Ophthalmology meeting.
“Changes are more pronounced and have a stronger increase ... when we measure in reflex tears,” principal investigator Sarah F. Hamm-Alvarez, PhD, told
“The diagnosis of Parkinson’s disease is challenging before patients develop motor symptoms such as tremor or other movement abnormalities,”

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