An intravitreal dose of ADVM-022, a gene therapy designed for long-term VEGF suppression via the expression of aflibercept, resulted in no anti-VEGF rescue injections for patients with wet age-related macular degeneration, according to 24-week clinical data in the OPTIC phase 1 clinical trial.
Six patients with wet AMD first received Eylea (aflibercept, Regeneron) to ensure a response, followed by one intravitreal dose of ADVM-022 of 6 × 1011 vg per eye in the multicenter, open-label OPTIC trial.
The primary endpoint of the phase 1 clinical trial was safety and tolerability, with
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