Genetic variation for primary open-angle glaucoma found in those with African ancestry

Primary open-angle glaucoma may be associated with a genetic variation in individuals with African ancestry, a study found.
The multicenter genome-wide association study included 26,295 subjects, of which 9,257 had primary open-angle glaucoma (POAG). A meta-analysis identified an association between glaucoma and variants at amyloid beta A4 precursor protein-binding family member B 2 (APBB2; chromosome 4, rs59892895T>C).
The rs59892895*C risk allele, which was found only in individuals with African ancestry, continued to show association with POAG risk.
“The increased risk associated

Full Story →