TREVISO, Italy — Complement C5 is a viable target for inhibition to potentially prevent or slow retinal pigment epithelial cell death in patients with geographic atrophy, according to one specialist.
“The role of complement in age-related macular degeneration has been well established. Downstream in the complement cascade, cleavage of complement C5 leads to the generation of C5a and C5b. C5a is involved in priming and activation of inflammasomes, while the generation of C5b may lead to the formation of membrane attack complex (MAC). Inflammasome activation or MAC accumulation both
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