Which treatment paradigm — local or systemic therapy — best treats bilateral noninfectious uveitis?

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There are distinct advantages of systemic therapy in terms of achieving control in both eyes, at a steady state, and without the risks for cataract and elevated IOP. Younger patients appreciate being able to preserve their accommodation and avoiding cataract surgery. Systemic therapy also avoids the sawtooth decline in vision that is seen with short-term local steroid delivery when the effect wears off and there is recurrence of inflammation.
There is robust data demonstrating the long-term

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