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Limbal stem cell deficiency with or without conjunctival deficiency can lead to sequelae that result in severe visual loss. While an ocular surface stem cell transplantation, or OSST, and keratoprosthesis are both viable options to rehabilitate vision, OSST should be seen as the first choice for most patients.
An OSST provides healthy limbal stem cells and conjunctiva to address the limbal stem cell deficiency. For unilateral disease, OSST autograft procedures (eg,
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