Post hoc analysis of ARIES study clarifies fluid-related criteria for treat-and-extend

A post hoc analysis of the ARIES study showed a correlation between presence of intraretinal fluid and poorer vision, while a stable, limited amount of subretinal fluid may be beneficial.
“These findings suggest that the use of combined SRF and IRF as a surrogate marker for BCVA and its use to guide treatment extension decisions alone should be reconsidered,” Paul Mitchell, MD, said at the virtual Euretina congress.
ARIES was a multicenter, randomized, open-label phase 3b/4 study evaluating the efficacy of aflibercept treat-and-extend regimen in patients with neovascular age-related

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