The regenerative capacity of stem cells has been of great interest in every field of medicine.
The additional role of a pericorneal structure contributing to epithelial regeneration was first postulated in 1971. Detailed evaluation of the limbal palisades of Vogt hypothesized the presence of repository cells in the interpalisadal region. The XYZ hypothesis further elaborated the role of centripetal movement of peripheral cells (Y) along with proliferation of basal cells (X) to replace epithelial cell loss (Z) in the cornea. A recent report by Dua and colleagues suggests the existence (Read more...)