Individuals with a high polygenic risk for glaucoma have similar likelihood to develop the disease as those with the most common single-gene pathogenic variant and at an equivalent age, according to a study.
Polygenic risk was also found to be 15 times higher in the general population than the single-gene variant.
Out of 2,507 individuals included in the Australian and New Zealand Registry of Advanced Glaucoma (ANZRAG), 109 were identified as monogenic, presenting a pathogenic heterozygous variant in the myocilin (MYOC) gene, the most common glaucoma-causing gene. Of all MYOC variants,