The demographic distribution of race and ethnicity in most randomized clinical trials does not reflect that of the U.S. population, according to a cross-sectional retrospective analysis.
The study authors focused on diabetic macular edema and retinal vein occlusion in their search of PubMed and ClinicalTrials.gov to identify phase 3 randomized clinical trials (RCTs) conducted in the U.S. between 2004 and 2020. Twenty-three trials were included, and the number and percentage of different races and ethnicities were recorded. The demographic distribution in the studies was then compared with the