Ocular surface squamous neoplasia is used to describe neoplastic epithelial abnormalities of the conjunctiva and cornea, ranging from squamous dysplasia to invasive squamous cell carcinoma.
The etiology of ocular surface squamous neoplasia (OSSN) is mainly due to exposure to ultraviolet radiation, immune suppression, HIV, HPV mutation or deletions of tumor suppressor gene p53.
OSSN coexisting with fungal corneal ulcer is a rare case scenario that has been sparsely reviewed in literature. Immune predisposition may be the common factor to cause both conditions. Here, we present a patient with the