We are pleased with the expressed interest in our work and appreciate the comments of Drs Mamalis and Edelhauser. This rabbit study was undertaken as part of the Food and Drug Administration’s Proactive Toxic Anterior Segment Syndrome (TASS) program to…
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Classification of Secondary Corneal Amyloidosis and Involvement of Lactoferrin – Corrected Proof
Purpose:
To classify secondary corneal amyloidosis (SCA) by its clinical appearance, to analyze the demographics of the patients, and to determine the involvement of lactoferrin.
Design:
Retrospective, observational, noncomparative, multicenter stu…
Streptococcus Endophthalmitis Outbreak after Intravitreal Injection of Bevacizumab: One-Year Outcomes and Investigative Results – Corrected Proof
Purpose:
To report the 1-year clinical outcomes of an outbreak of Streptococcus endophthalmitis after intravitreal injection of bevacizumab, including visual acuity outcomes, microbiological testing, and compound pharmacy investigations by the Food a…
Glaucoma Severity and Medication Adherence in a County Hospital Population – Corrected Proof
Objective:
To assess the association between disease severity and adherence with glaucoma medications in a county hospital population.
Design:
Cross-sectional study.
Participants:
A total of 126 patients diagnosed with glaucoma receiving intraocular pressure (IOP)–lowering medication were recruited from the San Francisco General Hospital Ophthalmology Clinic.
Methods:
Subjects completed an oral questionnaire to assess demographic information, knowledge of glaucoma, and perceptions of glaucoma medication adherence. Glaucoma disease severity was classified according to the American Academy of Ophthalmology’s Preferred Practice Pattern guidelines. Medication adherence was measured for each patient by obtaining pharmacy refill data and calculating medication possession ratio (MPR), that is, (Read more...)
Ranibizumab Treatment Outcomes in Phakic versus Pseudophakic Eyes: An Individual Patient Data Analysis of 2 Phase 3 Trials – Corrected Proof
Objective:
To compare visual outcomes in phakic and pseudophakic eyes treated with monthly intravitreal ranibizumab for exudative age-related macular degeneration (AMD).
Design:
Meta-analysis of individual patient data from 2 phase 3 clinical trial…
A Phenotype–Genotype Correlation Study of X-Linked Retinoschisis – Corrected Proof
Purpose:
To compare the clinical phenotype and detailed electroretinographic parameters in X-linked retinoschisis (XLRS).
Design:
Retrospective, comparative study.
Participants:
Fifty-seven patients (aged 1–67 years) with molecularly confirmed …
Higher Prevalence of Myocilin Mutations in Advanced Glaucoma in Comparison with Less Advanced Disease in an Australasian Disease Registry – Corrected Proof
Objectives:
To determine the proportion of all Myocilin coding mutations responsible for advanced primary open-angle glaucoma (POAG) in early-age-at-onset individuals and to investigate the prevalence of exon 3 Myocilin mutations in advanced POAG at …
Toward Zero Effective Phacoemulsification Time Using Femtosecond Laser Pretreatment – Corrected Proof
Objective:
To compare effective phacoemulsification time after femtosecond laser pretreatment with conventional phacoemulsification and the associated effect on visual outcomes and endothelial cell loss.
Design:
Prospective, consecutive, single-surgeon case-control study.
Controls:
Controls underwent phacoemulsification cataract extraction plus insertion of an intraocular lens (IOL). Cases underwent pretreatment with the femtosecond laser followed by phacoemulsification cataract extraction and IOL insertion.
Methods:
Two hundred one eyes underwent cataract surgery between April 2012 and July 2012. Data collected included patient demographics, preoperative characteristics, femtosecond lens fragmentation method, effective phacoemulsification time (EPT), intraoperative complications, and postoperative outcomes.
Main Outcome Measures:
Effective phacoemulsification time, intraoperative complications, (Read more...)
Features of Recurrence after Excimer Laser Phototherapeutic Keratectomy for Anterior Corneal Pathologies in North China – Corrected Proof
Purpose:
To study long-term clinical patterns of recurrence of anterior corneal pathologies after excimer laser phototherapeutic keratectomy (PTK).
Design:
Retrospective, noncomparative, interventional case series.
Participants:
Thirty patients (…
Outdoor Activity during Class Recess Reduces Myopia Onset and Progression in School Children – Corrected Proof
Purpose:
The aim of this study was to investigate the effect of outdoor activity during class recess on myopia changes among elementary school students in a suburban area of Taiwan.
Design:
Prospective, comparative, consecutive, interventional study.
Participants:
Elementary school students 7 to 11 years of age recruited from 2 nearby schools located in a suburban area of southern Taiwan.
Intervention:
The children of one school participated in the interventions, whereas those from the other school served as the control group. The interventions consisted of performing a recess outside the classroom (ROC) program that encouraged children to go outside for outdoor (Read more...)
Reading Performance in Infantile Nystagmus – Corrected Proof
Objective:
To characterize reading deficits in infantile nystagmus (IN), to determine optimal font sizes for reading in IN, and to investigate whether visual acuity (VA) and severity of nystagmus are good indicators of reading performance in IN.
Design:
Prospective cross-sectional study.
Participants and Controls:
Seventy-one participants with IN (37 idiopathic, 34 with albinism) and 20 age-matched controls.
Methods:
Reading performance was assessed using Radner reading charts and was compared with near logarithm of the minimum angle of resolution (logMAR) VA, nystagmus intensity, and foveation characteristics as quantified using eye movement recordings.
Main Outcome Measures:
Reading acuity (smallest readable font size), (Read more...)
Peripheral Autofluorescence and Clinical Findings in Neovascular and Non-neovascular Age-related Macular Degeneration – Corrected Proof
Purpose:
To characterize peripheral fundus autofluorescence (FAF) abnormalities in patients with age-related macular degeneration (AMD), correlate these with clinical findings, and identify risk factors associated with these FAF abnormalities.
Design:
Clinic-based, cross-sectional study.
Participants:
A total of 119 consecutive patients: 100 patients with AMD (200 eyes) and 19 patients without AMD (38 eyes).
Methods:
In a prospective study performed at the Doheny Eye Institute, University of Southern California, widefield 200-degree FAF and color images were obtained by the Optos 200Tx Ultra-Widefield device (Optos, Dunfermline, Scotland) using a standardized imaging protocol. The FAF images were captured centered on the fovea, and (Read more...)
One-Year Strabismus Outcomes in the Infant Aphakia Treatment Study – Corrected Proof
Objective:
To evaluate the characteristics of strabismus in infants who underwent cataract surgery with and without intraocular lens (IOL) implantation.
Design:
Secondary outcome analysis in a prospective, randomized clinical trial.
Participants:
The Infant Aphakia Treatment Study is a randomized, multicenter (n = 12), clinical trial comparing treatment of aphakia with a primary IOL or contact lens in 114 infants with a unilateral congenital cataract.
Intervention:
Infants underwent cataract surgery with or without placement of an IOL.
Main Outcome Measures:
The proportion of patients in whom strabismus developed during the first 12 months of follow-up was calculated using the life-table method (Read more...)
Comparison of Treatment Regimens for Cytomegalovirus Retinitis in Patients with AIDS in the Era of Highly Active Antiretroviral Therapy – Corrected Proof
Purpose:
To describe the outcomes of different treatment approaches for cytomegalovirus (CMV) retinitis in the era of highly active antiretroviral therapy (HAART).
Design:
Prospective cohort study, the Longitudinal Study of the Ocular Complications of AIDS.
Participants:
A total of 250 patients with CMV retinitis and a CD4+ T-cell count <100 cells/μl (n = 221) at enrollment or incident retinitis (n = 29) during cohort follow-up.
Methods:
The effects of systemic therapy (vs. intraocular therapy only) on systemic outcomes and the effect of intraocular therapies (ganciclovir implants, intravitreal injections) on ocular outcomes were evaluated.
Main Outcome Measures:
Mortality, CMV dissemination, retinitis (Read more...)
Body Stature Growth Trajectories during Childhood and the Development of Myopia – Corrected Proof
Purpose:
Stature at a particular age can be considered the cumulative result of growth during a number of preceding growth trajectory periods. We investigated whether height and weight growth trajectories from birth to age 10 years were related to refractive error at ages 11 and 15 years, and eye size at age 15 years.
Design:
Prospective analysis in a birth cohort.
Participants:
Children participating in the Avon Longitudinal Study of Parents and Children (ALSPAC) U.K. birth cohort (minimum N = 2676).
Methods:
Growth trajectories between birth and 10 years were modeled from a series of height and weight measurements (N (Read more...)
Predictive Value in Retinal Vein Occlusions of Early Versus Late or Incomplete Ranibizumab Response Defined by Optical Coherence Tomography – Corrected Proof
Purpose:
To determine if optical coherence tomography (OCT) at baseline or month 3 in the Treatment of Macular Edema following Branch Retinal Vein Occlusion: Evaluation of Efficacy and Safety (BRAVO) and Treatment of Macular Edema following Central Retinal Vein Occlusion: Evaluation of Efficacy and Safety (CRUISE) studies provides information that predicts visual outcome.
Design:
Post hoc analysis from 2 prospective, randomized, controlled clinical trials.
Participants:
Three hundred ninety-seven patients from the BRAVO study and 392 patients from the CRUISE study.
Methods:
Time-domain OCT imaging data were analyzed.
Main Outcome Measures:
Mean change from baseline best-corrected visual acuity (BCVA) letter score (Read more...)
Evaluation of Moxifloxacin 0.5% in Treatment of Nonperforated Bacterial Corneal Ulcers: A Randomized Controlled Trial – Corrected Proof
Purpose:
To compare the equivalence of moxifloxacin 0.5% with a combination of fortified cefazolin sodium 5% and tobramycin sulfate 1.3% eye drops in the treatment of moderate bacterial corneal ulcers.
Design:
Randomized, controlled, equivalence cl…
How Does Glaucoma Look? Patient Perception of Visual Field Loss – Corrected Proof
Objective:
To explore patient perception of vision loss in glaucoma and, specifically, to test the hypothesis that patients do not recognize their impairment as a black tunnel effect or as black patches in their field of view.
Design:
Clinic-based …
Changes in Ocular Flora in Eyes Exposed to Ophthalmic Antibiotics – Corrected Proof
Purpose:
To determine changes in ocular flora in individuals repeatedly exposed to topical macrolide or fluoroquinolone antibiotics.
Design:
Prospective, controlled, longitudinal study with 1-year follow-up.
Participants:
Forty-eight eyes of 24 patients undergoing serial unilateral intravitreal injection for choroidal neovascularization.
Methods:
Patients received 4 consecutive monthly unilateral intravitreal injections and were then treated as needed. Each patient was randomized to 1 of 4 antibiotics (azithromycin 1%, gatifloxacin 0.3%, moxifloxacin 0.5%, ofloxacin 0.3%) and used only their assigned antibiotic for 4 days after each injection. Conjunctival cultures of the treated eye and untreated fellow eye (control) were taken at baseline and before (Read more...)