Author: Ophthalmology

Oral Docosahexaenoic Acid in the Prevention of Exudative Age-Related Macular Degeneration: The Nutritional AMD Treatment 2 Study

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Objective: To evaluate the efficacy of docosahexaenoic acid (DHA)–enriched oral supplementation in preventing exudative age-related macular degeneration (AMD).Design: The Nutritional AMD Treatment 2 study was a randomized, placebo-controlled, double-blind, parallel, comparative study.Participants: Two hundred sixty-three patients 55 years of age or older and younger than 85 years with early lesions of age-related maculopathy and visual acuity better than 0.4 logarithm of minimum angle of resolution units in the study eye and neovascular AMD in the fellow eye.Methods: Patients were assigned randomly to receive either 840 mg/day DHA and 270 mg/day (Read more...)

A Quantitative Method for Assessing the Degree of Axial Proptosis in Relation to Orbital Tissue Involvement in Graves’ Orbitopathy – Corrected Proof

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Purpose:
To define a method of quantifying axial proptosis in patients with Graves’ orbitopathy (GO) and to validate a score that correlates with the orbital involvement and helps determine the degree of proptosis correction for elective orbital decompression.

Design:
Retrospective, case series.

Participants:
The study included 50 patients (group A) and 29 control subjects who underwent orbital computed tomography (CT). The method was then validated in another group of 21 patients with GO (group B).

Methods:
The orbital area (OA) was measured manually on the central axial section of the CT scan at a level where the lens is visualized. (Read more...)

Effect of Day Length on Eye Growth, Myopia Progression, and Change of Corneal Power in Myopic Children

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Objective:
Because of the northern location of Denmark, the length of the day over the year varies from 7 to 17.5 hours. Experimental and clinical results suggest that the development of myopia may be related to ambient light exposure. The purpose of current study was to investigate whether axial eye growth, myopia progression, or corneal power change in Danish myopic children varies with the length of the day.

Design:
Cross-sectional study.

Participants:
Two hundred thirty-five children 8 to 14 years of age found to have myopia during screening for a (Read more...)

Treatment Outcomes in Malignant Glaucoma

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Purpose:
To report treatment outcomes in malignant glaucoma.

Design:
Retrospective case series.

Participants:
Twenty-eight eyes of 26 patients who were treated for malignant glaucoma between 1991 and 2009.

Methods:
Malignant glaucoma was diagnosed based on the presence of a shallow or flat central and peripheral anterior chamber in the presence of patent iridotomy, with intraocular pressure (IOP) of 22 mmHg or more after any intraocular surgery. The treatment algorithm included antiglaucoma medications and cycloplegics as first-line methods; the second-line therapy in pseudophakic eyes was laser hyaloidotomy, followed by vitrectomy-hyaloidotomy-iridectomy (VHI) (Read more...)

Fuchs’ Endothelial Corneal Dystrophy: Subjective Grading versus Objective Grading Based on the Central-to-Peripheral Thickness Ratio

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Purpose:
To assess interobserver agreement between 2 corneal specialists grading Fuchs’ dystrophy clinically and to determine if the corneal central-to-peripheral thickness ratio (CPTR) may be an alternative and objective metric of disease severity.

Design:
Cross-sectional study.

Participants:
Forty-five eyes (26 subjects) with mild and moderate Fuchs’ dystrophy, 73 eyes (60 subjects) with advanced Fuchs’ dystrophy, and 267 eyes (142 subjects) with normal corneas.

Methods:
Corneas with Fuchs’ dystrophy were graded by 2 corneal specialists based on the confluence and area of guttae and the presence or absence of edema. Central (Read more...)