Researchers at Nagoya University in Japan have developed a nanowire assay that can be used to capture and detect specific extracellular vesicles in a urine sample that indicate the presence of a brain tumor. These extracellular vesicles are naturally excreted in the urine but techniques to capture and analyze them have been complex, requiring different […]
Tag: Materials
3D Bioengineered Skin Grafts Fit Complex Anatomy
Researchers at Columbia University’s Irving Medical Center have developed a method to create three-dimensional bioengineered skin grafts. To date, bioengineered skin is typically created in flat sheets. However, these are difficult to fit to complex anatomy, such as the hand, and so these researchers have designed a more sophisticated technique that combines laser scanning, 3D […]
Hydrogel Cell Carrier for Fistula Healing
Researchers at Johns Hopkins created an injectable hydrogel carrier vehicle for stem cells that is intended to aid in healing a difficult complication of Crohn’s disease, perianal fistulas. Perianal fistulas are very challenging to treat, but stem cells have shown promise in assisting with this process. However, it is difficult to get the cells to […]
Antibacterial Peptide Spray Safe for Use on Wounds
Researchers at Chalmers University of Technology in Sweden have developed an antimicrobial spray that is safe to use on wounds and in the body, including as an antimicrobial coating on implantable or in-dwelling devices, such as urinary catheters. The technology is not based on harsh chemical antiseptics or antibiotic drugs that could aggravate tissue or […]
Biobots Use Optogenetic Muscle Actuators for Movement
Researchers at the University of Illinois at Urbana-Champaign have developed centimeter-scale biobots that combine soft materials, mouse muscle tissue, and wireless electronic components. The tiny devices can be controlled remotely through optogenetics. The muscle within the devices forms an optogenetic actuator and creates movement when exposed to light. The researchers can control this movement remotely […]
Hydrogel Scaffold Makes a Living Electrode
A team of researchers at the Harvard Wyss Institute have developed a soft, hydrogel scaffold that can function as a living electrode for brain-computer interface applications. The researchers used electrically conductive materials and created a porous and flexible scaffold using a freeze-drying process. They then seeded the scaffold with human neural progenitor cells (NPCs) and […]
Bioprinted Eye Tissue to Study Retinal Diseases
Researchers at the National Eye Institute, which is part of the National Institutes of Health, have created a method to 3D bioprint eye tissue that forms the outer blood-retina barrier. This tissue supports the photoreceptors in the retina and is implicated in the initiation of age-related macular degeneration. The researchers combined different cell types, which […]
Improved Membrane Coating for Anti-Cancer Nanoparticles
Scientists at the University of Eastern Finland have developed a technique that lets them improve the coating of nanoparticles when using cell membranes. Cell membranes offer a lot of benefits as a coating for synthetic nanoparticles, including shielding from the immune system, prolonged circulation times and improved tumor accumulation. However, current approaches to coating nanoparticles […]
Electrospun Construct Mimics Elasticity of Blood Vessels
Researchers at the University of Sydney in Australia have developed an electrospun blood vessel replacement. The material contains tropoelastin, a natural precursor for elastin, a key component of blood vessel walls. Elastin is present in concentric circles in natural blood vessels and provides the elastic properties which allow them to distend slightly and then reform […]
Flexible Sensors Measure Fit of Face Masks
Researchers at MIT have developed a sensor system that can provide data on how well a face mask fits to a wearer’s face. The protection offered by a mask is largely dependent on how well it fits the face, but at present most face masks are one-size-fits-all and most wearers are largely unaware if their […]
3D Bioprinted Breast Tumors for Immunotherapy Testing
A team of scientists at Penn State has bioprinted breast tumor mimics with significant complexity, including a form of vascularization and the ability to precisely place cells in certain locations within the construct. The scientists used a technique called aspiration-assisted bioprinting to achieve this. With many anti-cancer therapies failing at the clinical trial stage and […]
Low Temperature Graphene Coating for Enhanced Wearables
Researchers at Caltech came up with a technique to coat flexible electronic circuits with graphene to enhance their durability on folding, as well as to improve their resistance to sweat (in the case of graphene-coated gold) and their conductivity. The method could enhance the flexible electronics that are employed in many medical wearables. The approach […]
AI-Designed Custom Knee Implants
Scientists at the University of Birmingham in the UK have trialed Generative Design, a design approach that relies on machine learning and artificial intelligence, to create patient-specific knee implants. At present, knee implants are typically created in a limited range of sizes and shapes. While 3D printing has opened some scope for implants that are […]
Conductive Cotton Thread for Wearable Sensors in Commercial Textiles
Imperial College London researchers created a conductive cotton thread that can undergo a computerized embroidery process for incorporation into commercially produced textiles, such as t-shirts and face masks. The thread, called PECOTEX, can be used to create wearable health sensors, such as heart rate monitors, breathing monitors and even gas sensors, including ammonia sensors for […]
Robotic Capsule Drills Intestinal Mucus to Deliver Protein Drugs
Engineers at MIT have collaborated to develop a robotic drug delivery capsule that is specially designed to administer delicate protein drugs, such as insulin, through the wall of the intestine. Proteins are not suited for oral delivery, as they are typically destroyed by the low pH in the intestine and they can’t pass through the […]
DNA Nets Capture Sars-CoV-2 for Detection and Inhibition
A team at the University of Illinois at Urbana-Champaign has developed a DNA net system that can ensnare Sars-CoV-2 and bind to the notorious spike protein. The nets contain aptamers that bind the spike protein and emit an intense fluorescent signal once they’re bound together to the protein. This signal can be easily measured using […]
Soft Robot Grows Like a Plant to Travel Through Tight Spaces
At the University of Minnesota, researchers have developed a soft robotic system that can ‘grow’ like a plant. The mechanism allows it to travel through difficult-to-access areas, such as the tortuous gastrointestinal tract or vasculature. The system works by extruding a liquid through an opening in the device, and at the same time a photopolymerization […]
Algae-Based Microrobots Deliver Antibiotics within Lungs
Researchers at the University of California San Diego have developed a microrobot system to treat bacterial pneumonia. The microrobots consist of living algal cells that can swim very effectively in biological fluids, allowing them to navigate throughout the lungs and deliver drugs to difficult-to-reach areas. The algal cells are studded with antibiotic-loaded polymer spheres that […]
Soft Robot Biodegrades Inside Body
Researchers at the City University of Hong Kong have developed a magnetic soft millirobot that can grab and release objects, and move around by rolling. The device can be controlled using magnetic fields, and consists of a biodegradable gelatin and iron oxide microparticles. The technology has significant potential as a minimally invasive drug delivery system, […]
Alveoli on a Chip to Reveal Airflow Characteristics in Disease and Drug Delivery
Researchers at the Harbin Institute of Technology in China have developed a microfluidic-style chip that models the alveoli present in our airways. The tiny air sacs in our lungs are crucial for gas exchange, but they can be difficult to study and model. A better understanding of airflow patterns in these structures could be very […]