Latest Story
The Age-Related Maculopathy Susceptibility 2 Polymorphism and Polypoidal Choroidal Vasculopathy in Asian Populations: A Meta-Analysis – Corrected Proof
Objective: To assess the role of the age-related maculopathy susceptibility 2 (ARMS2) A69S polymorphism as a risk factor for polypoidal choroidal vasculopathy (PCV) in Asian populations.Methods: We performed a meta-analysis of the association of the A69S variant with PCV in Asian populations using data available from 14 case-control studies involving 6552 subjects. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using fixed- and random-effects models. Sensitivity analysis also was performed.Main Outcome Measure: Understanding the relationship between the A69S variant and PCV is essential to provide new insights into pathophysiology and potential targets for intervention of PCV.Results: The (Read more...)
Prevalence of Amblyopia or Strabismus in Asian and Non-Hispanic White Preschool Children: Multi-Ethnic Pediatric Eye Disease Study – Corrected Proof
Objective: To determine the age- and race-specific prevalence of amblyopia in Asian and non-Hispanic white children aged 30 to 72 months and of strabismus in children aged 6 to 72 months.Design: Cross-sectional survey.Participants: A population-based m multiethnic sample of children aged 6 to 72 months was identified in Los Angeles and Riverside counties in California to evaluate the prevalence of ocular conditions.Methods: A comprehensive eye examination and in-clinic interview were conducted with 80% of eligible children. The examination included evaluation of ocular alignment, refractive error, and ocular structures in children aged 6 to 72 months, as well as a determination (Read more...)
The Posterior Pole and Papillomacular Fold in Posterior Microphthalmos: Novel Spectral-Domain Optical Coherence Tomography Findings – Corrected Proof
Purpose: To report and analyze the spectral-domain optical coherence tomography (SD-OCT) features of the posterior pole and papillomacular fold (PMF) in posterior microphthalmos (PM) in relation to axial length of the globe and corneal power.Design: Comparative case series.Participants: Forty eyes of 20 PM patients and 70 eyes of 35 age-matched controls.Methods: All PM and control eyes underwent a full biometric evaluation, including axial length and corneal power measurements, and macular SD-OCT. In addition, a novel SD-OCT marker of the posterior pole curvature, termed the posterior pole curvature index (PPCI), was measured along both the vertical and horizontal meridians. The OCT characteristics of the (Read more...)
Parafoveal Scotoma Progression in Glaucoma: Humphrey 10-2 versus 24-2 Visual Field Analysis – Corrected Proof
Objective: To compare the performance of 10-2 versus 24-2 visual fields (VFs) in detecting progression of initial parafoveal scotoma (IPFS) in glaucomatous eyes.Design: Retrospective, observational study.Participants: Glaucoma patients with the following criteria: (1) an IPFS (≥3 adjacent points with P<0.05 within the central 10° degrees of fixation, 1 point or more with P<0.01 lying at the innermost paracentral points, and no scotoma outside the central 10°) in either hemifield based on 2 reliable Humphrey 24-2 Swedish interactive threshold algorithm standard VFs, and (2) 5 or more 10-2 and 24-2 VFs.Methods: Based on threshold map sensitivities, VF progression, defined as having (Read more...)
Subfoveal Choroidal Thickness in Diabetes and Diabetic Retinopathy – Corrected Proof
Purpose: To examine subfoveal choroidal thickness (SFCT) in patients with diabetes mellitus and patients with diabetic retinopathy.Design: Population-based, cross-sectional study.Participants: The population-based Beijing Eye Study 2011 included 3468 individuals with a mean age of 64.6±9.8 years (range, 50–93 years).Methods: A detailed ophthalmic examination was performed including spectral-domain optical coherence tomography (OCT) with enhanced depth imaging for measurement of SFCT and fundus photography for the assessment of diabetic retinopathy.Main Outcome Measures: Subfoveal choroidal thickness.Results: Fasting blood samples, fundus photographs, and choroidal OCT images were available for 2041 subjects (58.8%), with 246 subjects (12.1±0.7%) fulfilling the diagnosis of diabetes mellitus and 23 (Read more...)
AREDS2: Insights Into Optimal Supplements for AMD
The findings of the AREDS trials are put into perspective for clinicians.
Medscape Ophthalmology
Medscape Ophthalmology
Recombinant human albumin from Novozymes Biopharma helps innovative dry eye therapy move into clinical trials
Novozymes Biopharma, part of Novozymes A/S world leader in bioinnovation, today announced that an ophthalmic solution made using its recombinant human albumin, has been approved for Phase I/II development by the FDA.
Enhanced Depth Imaging Optical Coherence Tomography of the Choroid in Central Retinal Vein Occlusion – Corrected Proof
Purpose: To evaluate subfoveal choroidal thickness in patients with central retinal vein occlusion (CRVO) using enhanced depth imaging optical coherence tomography.Design: Retrospective observational study.Methods: We measured bilateral subfoveal choroidal thickness, averaged for 100 scans, in 36 patients (mean age, 66 ± 15 years; 26 women and 10 men) with unilateral CRVO by using the enhanced depth imaging methods of the Spectralis optical coherence tomography system. Twenty-two patients were treated with intravitreal bevacizumab (1.25 mg/0.05 mL), and subfoveal choroidal thickness was measured before and after treatment. Statistical analysis was performed to compare subfoveal choroidal thickness of CRVO and fellow eyes and to compare (Read more...)
Visual Impairment and Subsequent Use of Support Services Among Older People: Longitudinal Findings From the Blue Mountains Eye Study – Corrected Proof
Purpose: To assess the impact of visual impairment and blindness on the incident use of community support services in the Blue Mountains Eye Study.Design: Population-based cohort.Methods: Of 3654 baseline participants (1992-1994), 2334, 1952, and 1149 were re-examined after 5, 10, and 15 years, respectively. Incident visual impairment was defined as subsequent development of visual impairment (visual acuity <20/40) in the better eye of subjects with best-corrected visual acuity ≥20/40 at baseline. Community support service use included regular use of Meals on Wheels, Home Care, or community nurse services. Informal support included assistance from family or friends. Discrete logistic regression models (Read more...)
Outcomes of Outpatient Fluid-Gas Exchange for Open Macular Hole After Vitrectomy – Corrected Proof
Purpose: To report the efficacy and safety of outpatient fluid-gas exchange for open macular hole after primary vitrectomy.Design: Retrospective interventional case series.Methods: setting: Institutional. patients: Thirty-six patients with primary failed closure or reopened holes after primary vitrectomy. intervention: Fluid-gas excahnge with 15% perfluoropropane (C3F8) or 20% sulfur hexafluoride (SF6) was performed to reclose the hole under topical anesthesia. main outcome measures: The hole closure rate and type, pre- and postexchange best-corrected visual acuity (BCVA), and complication rates were assessed.Results: Thirty-two eyes (89%) achieved anatomic success from 1-3 weeks after the fluid-gas exchange. Twenty-two eyes (61%) achieved type 1 closure, 10 eyes (Read more...)
Antibiotic prophylaxis may have negative effect on safety of intravitreal injections
MILAN — A low rate of endophthalmitis after anti-VEGF intravitreal injections can be achieved without the use of preoperative and postoperative antibiotics. Antibiotic prophylaxis might, in fact, have a negative impact on the safety of the procedure, according to a speaker here.Alexander J. Brucker, MD, was awarded the Gian Battista Bietti SOI Medal Lecture 2013 at the annual joint meeting of Ocular Surgery News and the Italian Society of Ophthalmology.
Presbyopic ‘blended vision’ procedure provides effective outcomes
MILAN — Laser blended vision effectively addresses presbyopia in myopic and hyperopic patients, according to one surgeon.Presbyond (Carl Zeiss Meditec) combines micro-monovision with a bilateral procedure that increases depth of focus by addressing spherical aberration.
Normal-tension glaucoma progression linked to dips in nocturnal blood pressure
LA JOLLA, Calif. — Decreases in nocturnal blood pressure below the daytime mean arterial pressure and the significance of these dips are linked to normal-tension glaucoma progression, according to a study presented here."Glaucoma is a chronic degenerative disease, and currently the only way to control this progression is to lower intraocular pressure," Carlos Gustavo De Moraes, MD, said at the American Ophthalmological Society meeting.
Measuring genetic diversity within tumor predicts outcomes of patients with head and neck cancer
A new measure of the heterogeneity - the variety of genetic mutations - of cells within a tumor appears to predict treatment outcomes of patients with the most common type of head and neck cancer.
VEGF Inhibition Via TGF-B1 Suggested For Glaucoma Surgery
The most common cause of failure after glaucoma surgery is scarring at the surgical site, so researchers are actively looking for ways to minimize or prevent scar formation. Previous work had suggested that vascular endothelial growth factor (VEGF) activates fibrosis, whereas VEGF inhibition results in reduced scar formation and better surgical results...
Subscribe
