After eons of wandering in the dark, primates developed highly acute, three-color vision that permitted them to shift to daytime living, a new Dartmouth College study suggests…
Month: March 2013
People in the NorthWest with X-linked retinoschisis
XLRS Natural History Study Beginning in Portland, Oregon
March 29, 2013 – Oregon Health & Science University (OHSU) is launching a three-year natural history study for people with X-linked retinoschisis (XLRS). Funded by the Foundation Fighting Blindness, the investigation’s primary goal is to identify outcome measures — such as changes in vision or retinal structure — that could be useful in evaluating the effectiveness of potential therapies in clinical trials. The study will also help determine the types of XLRS patients most suitable for future therapeutic studies.
Knowledge gained from the XLRS natural history study will aid in the (Read more...)
Gene Therapy in Ophthalmology Update 18: A RetroSense Update
I first learned about the potential of using gene therapies in treating ophthalmic disorders back in November 2010. That’s when I was introduced to gene therapy by Sean Ainsworth, the founder and CEO of RetroSense Therapeutics. I haven’t written about this company or the unique approach it is taking to try and treat retinitis pigmentosa and the dry form of AMD since that first article, The Use of Gene Therapy in Treating Retinitis Pigmentosa and Dry AMD. With several news events occurring with the company recently, I felt it was time to bring readers of this blog up-to-date.
The Blind Aided By Virtual Games To Navigate Unknown Territory
JoVE (Journal of Visualized Experiments) has published a new video article by Dr. Lotfi Merabet showing how researchers in the Department of Ophthalmology at Massachusetts Eye and Ear Infirmary and Harvard Medical School have developed a virtual gaming…
Living cells and cell fragments move in response to electric fields, scientists find
Like tiny crawling compass needles, whole living cells and cell fragments orient and move in response to electric fields – but in opposite directions, scientists at the University of California, Davis, have found. Their results, published April 8 in th…
Radiology trainees face earning challenges
For years, medical students who chose a residency in radiology were said to be on the ROAD to happiness. The acronym highlighted the specialties -; radiology, ophthalmology, anesthesiology and dermatology -; said to promise the best lifestyle for docto…
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Femtosecond Laser-enabled Keratoplasty
How has the advent of the femtosecond laser revolutionized keratoplasty for the ophthalmic surgeon? International Ophthalmology Clinics
Development and Validation of a Predictive Model for Nonadherence with Once-Daily Glaucoma Medications – Corrected Proof
Objective:
To develop and validate a predictive model to estimate the probability of being nonadherent to topical glaucoma medications.
Design:
Prospective cohort study.
Participants:
Patients being treated with once-daily prostaglandin eye drops…
Development and Validation of a Predictive Model for Nonadherence with Once-Daily Glaucoma Medications – Corrected Proof
Objective:
To develop and validate a predictive model to estimate the probability of being nonadherent to topical glaucoma medications.
Design:
Prospective cohort study.
Participants:
Patients being treated with once-daily prostaglandin eye drops…
Ability of Cirrus High-Definition Spectral-Domain Optical Coherence Tomography Clock-Hour, Deviation, and Thickness Maps in Detecting Photographic Retinal Nerve Fiber Layer Abnormalities – Corrected Proof
Purpose:
To investigate the ability of clock-hour, deviation, and thickness maps of Cirrus high-definition spectral-domain optical coherence tomography (HD-OCT) in detecting retinal nerve fiber layer (RNFL) defects identified in red-free fundus photographs in eyes with early glaucoma (mean deviation >–6.0 dB).
Design:
Cross-sectional study.
Participants:
Two hundred ninety-five eyes with glaucomatous RNFL defects with clear margins observed in red-free fundus photographs and 200 age-, sex-, and refractive error–matched healthy eyes were enrolled.
Methods:
The width and location of RNFL defects were evaluated by using the red-free fundus photograph. When a RNFL defect detected by red-free fundus photograph did not present (Read more...)
Ability of Cirrus High-Definition Spectral-Domain Optical Coherence Tomography Clock-Hour, Deviation, and Thickness Maps in Detecting Photographic Retinal Nerve Fiber Layer Abnormalities – Corrected Proof
Purpose:
To investigate the ability of clock-hour, deviation, and thickness maps of Cirrus high-definition spectral-domain optical coherence tomography (HD-OCT) in detecting retinal nerve fiber layer (RNFL) defects identified in red-free fundus photographs in eyes with early glaucoma (mean deviation >–6.0 dB).
Design:
Cross-sectional study.
Participants:
Two hundred ninety-five eyes with glaucomatous RNFL defects with clear margins observed in red-free fundus photographs and 200 age-, sex-, and refractive error–matched healthy eyes were enrolled.
Methods:
The width and location of RNFL defects were evaluated by using the red-free fundus photograph. When a RNFL defect detected by red-free fundus photograph did not present (Read more...)
Anatomic Features and Function of the Macula and Outcome of Surgical Tenotomy and Reattachment in Achiasma – Corrected Proof
Objective:
To examine the anatomic features and function of the macula in achiasma and to compare visual acuity, eye movements, foveation, and eye velocity before and after tenotomy and reattachment (T&R) surgery.
Design:
Case series.
Participants:
Two children with isolated achiasma.
Methods:
Ophthalmologic examinations, brain magnetic resonance imaging, full-field and multifocal electroretinography (ERG), visual evoked potentials (VEPs), spectral-domain optical coherence tomography (OCT), eye-movement recordings, and unilateral T&R in 1 patient.
Main Outcome Measures:
Visual acuity before and after surgery, macular anatomic features and function, and eye velocity before and after T&R surgery in 1 patient.
Results:
Magnetic resonance imaging and (Read more...)
Intraocular Lens Delivery Characteristics of the Preloaded AcrySof IQ SN60WS/AcrySert Injectable Lens System – Corrected Proof
Objective: To evaluate the delivery characteristics of the AcrySof IQ SN60WS intraocular lens (IOL) injected via a preloaded AcrySert delivery system.Design: Prospective observational case series.Methods: setting: This study was carried out in the cata…
Long-term Botulinum Toxin Treatment of Benign Essential Blepharospasm, Hemifacial Spasm, and Meige Syndrome – Corrected Proof
Purpose: To report the clinical success and incidence of adverse events of repetitive botulinum toxin treatment of 15 years or greater.Design: Retrospective cohort study.Methods: The study sample consisted of 37 patients from a clinical practice, 11 ma…
Foveal Thickness in Healthy Fellow Eyes of Patients With Unilateral Macular Holes – Corrected Proof
Purpose: To compare the morphologic parameters of ophthalmoscopically and tomographically normal foveae of the fellow eyes of patients with a unilateral macular hole (MH), other unilateral retinal diseases, and healthy eyes.Design: Observational, cross-sectional study.Methods: Of the 849 subjects studied, 183 eyes were excluded because they had an abnormal vitreofoveal interface that might have affected the foveal thickness. The average regional retinal thicknesses of the Early Treatment Diabetic Retinopathy Study sectors determined by spectral-domain optical coherence tomography were compared among 160 patients with MH, 175 patients with epiretinal membrane, 145 patients with retinal vein occlusion, and 186 healthy subjects. The foveal depression (Read more...)