Appearance of Regressing Drusen on Optical Coherence Tomography in Age-related Macular Degeneration – Corrected Proof

Objective: To describe and interpret a multilaminar sub-retinal pigment epithelium (RPE) intense hyper-reflectivity observed in vivo in eyes clinically diagnosed with regressing drusen.Design: Observational case series.Participants: Twenty-three consecutive patients clinically diagnosed with regressing calcific drusen due to nonneovascular age-related macular degeneration (AMD).Methods: Patients were submitted to confocal scanning laser ophthalmoscopy (cSLO) fundus imaging and “eye-tracked” spectral-domain optical coherence tomography (SD-OCT).Main Outcome Measures: Localization and possible origin and composition of the multilaminar sub-RPE hyperreflectivity.Results: Thirty eyes of 23 consecutive patients (8 male and 15 female; mean age, 82.7±10.1 years) showing on SD-OCT an intense multilaminar sub-RPE hyperreflectivity, which matched with regressing calcific (Read more...)

Full Story →