Treatment of CIN with Retinoic Acid and Topical Interferon Alfa-2b
I have read with interest the recent report from Krilis et al about topical treatment of conjunctiva-cornea intraepithelial neoplasia (CIN) using a combination of 1 million IU/ml topical interferon (INF)-α2b drops 4 times daily and 0.01% retinoic acid once every second day. They concluded that 0.01% topical transretinoic acid once every second day and INF-α2b may act synergistically and that a combined treatment of INF-α2b and retinoic acid may offer a superior alternative to INF-α2b alone when treating CIN. This combination resulted in quicker clinical resolution of CIN than that of (Read more...)