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Can ionizing radiation be used as an adjunctive treatment for neovascular age-related macular degeneration (AMD)? In the INTREPID study of low-voltage, external-beam, stereotactic radiotherapy (SRT), Jackson et al (p. 1893) found that SRT can significantly reduce the need for retreatment with intravitreal injections of ranibizumab in AMD patients. In this double-masked, sham-controlled study, 230 patients were randomized to receive pro re nata (PRN) ranibizumab plus either 16 Gy, sham 16 Gy, 24 Gy, or sham 24 Gy; data from the 2 sham arms were pooled for all analyses. At the end (Read more...)

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