What condition do you suspect is present in this 8-year-old girl with blurry vision? Medscape Ophthalmology
Month: October 2013
The Diurnal and Nocturnal Effect of Travoprost With SofZia on Intraocular Pressure and Ocular Perfusion Pressure – Corrected Proof
Purpose: To determine the 24-hour effects of travoprost with sofZia on intraocular pressure (IOP) and ocular perfusion pressure as well as the endurance of IOP lowering after last dosing.Design: Prospective, open-label study.Methods: Forty subjects with open-angle glaucoma or ocular hypertension were admitted to our sleep laboratory for three 24-hour sessions monitoring IOP, blood pressure (BP), and heart rate. The first baseline session occurred after medication washout or immediately after enrollment for treatment-naïve patients. A second 24-hour monitoring session was performed after 4 weeks of once-nightly treatment of travoprost with sofZia. The medication was then discontinued and a third 24-hour session was completed 60-84 hours after the (Read more...)
Indications and Outcomes of Intraocular Lens Exchange During a Recent 5-Year Period – Corrected Proof
Purpose: To analyze and classify the indications, clinical presentations, and surgical outcomes of intraocular lens (IOL) exchange performed in a recent 5-year period.Design: Retrospective, interventional case series.Methods: setting: Private clinical practice. study population: Chart records of 57 eyes of 53 consecutive patients who had undergone IOL exchange between May 2007 and December 2011 were reviewed. observation procedures and main outcome measures: The preoperative clinical characteristics, treatment parameters, intraoperative and postoperative complications, and pre- and postoperative logarithm of the minimal angle of resolution (logMAR) best-corrected visual acuity (BCVA) were recorded and analyzed.Results: IOL dislocation (46%), incorrect IOL power (23%), patient dissatisfaction (Read more...)
A 5-Year Audit of Cataract Surgery Outcomes After Posterior Capsule Rupture and Risk Factors Affecting Visual Acuity – Corrected Proof
Purpose: To describe the posterior capsule rupture rates and visual outcomes after phacoemulsification, analyze risk factors for poor vision, and compare results of faculty (F) and residents (R).Design: Retrospective audit study.Methods: Visual success of all capsule ruptures (2006-2010) was analyzed and compared to uneventful cases. Rupture rates of faculty and residents were compared (χ², P < .05). Success was defined as % best-corrected visual acuity (BCVA) ≥20/40 at 3 months (excluding poor-prognosis eyes) and studied in relation to age, sex, surgeon type, stage of surgery, vitreous loss, dropped nucleus, and other complications (eg, retinal detachment, corneal decompensation, dislocated intraocular lens [IOL]). (Read more...)
Risk Factors Associated With Night Vision Disturbances After Phakic Intraocular Lens Implantation – Corrected Proof
Purpose: To investigate the incidence and severity of night vision disturbances after implantable collamer lens surgery and to analyze the risk factors.Design: Retrospective, noncomparative study.Methods: Medical charts from 50 eyes of 25 patients who …
The Effect of Phacoemulsification on Intraocular Pressure in Medically Controlled Open-Angle Glaucoma Patients – Corrected Proof
Purpose: To evaluate intraocular pressure (IOP) after phacoemulsification in patients with medically controlled open-angle glaucoma (OAG), and examine the association of biometric variables to IOP changes.Design: Retrospective case series.Methods: Open-angle glaucoma patients without prior incisional glaucoma surgery undergoing phacoemulsification by a single surgeon between January 1997 and October 2011 were evaluated. Patient charts were reviewed to obtain demographic information, preoperative glaucoma medications, severity and treatment measures, and preoperative and postoperative IOP.Results: A total of 157 eyes (157 patients) were included in the study. The average preoperative IOP of 16.3 ± 3.6 mm Hg decreased to 14.5 ± 3.4 mm Hg at 1 (Read more...)
Advances in Anterior Segment OCT
Dr. Roger Steinert explores some of the latest advancements in anterior segment optical coherence tomography (OCT) and their potential beneficial impact on clinical practice. Medscape Ophthalmology
Ab interno trabeculotomy best suited for patients with higher target IOP
Ab interno trabeculotomy may be most appropriate for open-angle glaucoma patients with a target IOP of 21 mm Hg or higher, according to a study.The retrospective study included 246 patients who underwent ab interno trabeculotomy with the Trabectome (NeoMedix).Two criteria were established to define success. Criterion A was postoperative IOP of 21 mm Hg or less and a 20% or greater reduction in IOP. Criterion B was postoperative IOP of 18 mm Hg or less and a 20% or greater reduction in IOP.
BLOG: Account for seasonal lulls when worried about a light appointment book, part 2
Markets with profound seasonal swings — the sunshine and permafrost belts of the country where the snowbirds come and go — are particularly susceptible to significant semi-annual volume fluctuations. These can be addressed in three main ways:
Expedited FDA reviews examined in new study
Of the drugs approved by the FDA in 2008, those that received expedited reviews were approved more quickly, were studied in fewer patients and still have unanswered safety questions, according to new data published in JAMA Internal Medicine.“Under the Obama administration, the FDA may also change the testing requirements for many drugs prior to approval; the stated rationales are promoting innovation and reducing the time and cost of discovering new drugs,” researchers wrote.
STAAR Surgical reports $17.1 million in total sales for third quarter
Sales at STAAR Surgical totaled $17.1 million for the third quarter, an 7.8% increase from the same period in 2012, the company reported in a news release.U.S. sales increased 7% and units grew 9%, with continuing signs that LASIK procedures are declining or flat.For the 9-month period ending Sept. 27, sales increased to $53.3 million, a $6 million increase from the same period in 2012.Third-quarter IOL sales totaled $5.3 million, a 12% decrease from the same period in 2012.
Intraoperative Refractive Biometry for Predicting Intraocular Lens Power Calculation after Prior Myopic Refractive Surgery – Corrected Proof
Purpose: To evaluate a new method of intraoperative refractive biometry (IRB) for intraocular lens (IOL) power calculation in eyes undergoing cataract surgery after prior myopic LASIK or photorefractive keratectomy.Design: Retrospective consecutive cases series.Participants: We included 215 patients undergoing cataract surgery with a history of myopic LASIK or photorefractive keratectomy.Methods: Patients underwent IRB for IOL power estimation. The Optiwave Refractive Analysis (ORA) System wavefront aberrometer was used to obtain aphakic refractive measurements intraoperatively and then calculate the IOL power with a modified vergence formula obtained before refractive surgery. Comparative effectiveness analysis was done for IRB predictive accuracy of IOL power determination (Read more...)
Assessing the Cone Photoreceptor Mosaic in Eyes with Pseudodrusen and Soft Drusen In Vivo Using Adaptive Optics Imaging – Corrected Proof
Purpose: To investigate the cone photoreceptor mosaic in eyes with pseudodrusen as evidenced by the presence of subretinal drusenoid deposits (SDD) and conventional drusen using adaptive optics (AO) imaging integrated into a multimodal imaging approach.Design: Observational case series.Participants: Eleven patients (11 eyes) with pseudodrusen and 6 patients (11 eyes) with conventional drusen.Methods: Consecutive patients were examined using near-infrared reflectance (IR) confocal scanning laser ophthalmoscopy (SLO) and eye-tracked spectral-domain optical coherence tomography (SD-OCT) and flood-illuminated retinal AO camera of nonconfluent pseudodrusen or conventional drusen. Correlations were made between the IR-SLO, SD-OCT, and AO images. Cone density analysis was performed on AO (Read more...)
In Vivo Confocal Microscopy Analyses of Corneal Microstructural Changes in a Prospective Study of Collagen Cross-linking in Keratoconus – Corrected Proof
Purpose: To use in vivo confocal microscopy (IVCM) to quantitatively analyze microstructural changes over time, after corneal collagen cross-linking for keratoconus.Design: Prospective cohort study.Participants: A total of 38 eyes of 38 patients undergoing collagen cross-linking for keratoconus.Methods: Prospective, clinical cohort study of corneal collagen cross-linking in progressive keratoconus. Laser scanning IVCM performed preoperatively and at 1, 3, 6, and 12 months postoperatively.Main Outcome Measures: Density of corneal sub-basal nerves, anterior and posterior keratocytes, and corneal endothelium.Results: Compared with baseline values, the mean sub-basal nerve density decreased significantly at 1, 3, and 6 months postoperatively (P < 0.01); however, this returned to preoperative values (Read more...)
Advances in Anterior Segment OCT
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Dr. Roger Steinert explores some of the latest advancements in anterior segment optical coherence tomography (OCT) and their potential beneficial impact on clini…
‘Ancient brain’ helps us interpret edges
Scientists from Australia believe they have found the brain cells that recognize patterns. And, surprisingly, they were not in the “modern” part of the brain, but in the thalamus, or “ancient” brain. The findings, published in The Journal of Neuroscien…
VMA does not affect anti-VEGF treatment for polypoidal choroidal vasculopathy
The presence of vitreomacular adhesion had an insignificant effect on visual outcomes after intravitreal anti-VEGF injections for the treatment of polypoidal choroidal vasculopathy, according to a study.The retrospective study included 104 eyes of 102 patients with polypoidal choroidal vasculopathy. Eyes were assigned to two groups; 23 eyes had vitreomacular adhesion (VMA) and 81 eyes did not have VMA.Investigators compared logMAR best corrected visual acuity and central macular thickness between the groups at baseline and at 1, 3, 6 and 12 months after anti-VEGF treatment.
NICE recommends reimbursement for Jetrea in England, Wales
The final ruling recommended reimbursing Jetrea (ocriplasmin, ThromboGenics/Alcon) for patients with vitreomacular traction and full-thickness macular holes up to 400 µm in diameter in the absence of epiretinal membrane.The ruling also recommended reimbursing Jetrea when used to treat patients with metamorphopsia, an early symptom of vitreomacular traction.
GrayBug announces funding round, appointment of president, CEO
GrayBug announced the close of a Series A funding round of $1.5 million, according to a press release.The funding will be used for the development of drug delivery therapies, working toward human clinical trials in wet age-related macular degeneration …
New Dementia Service Center established as pilot project
In Germany, approximately 1.3 million people currently suffer from dementia. About 250,000 incident cases are estimated per year. Dementia is the leading cause of dependency and disability among older persons.