Management and Outcome of Retinoblastoma with Vitreous Seeds – Corrected Proof

Purpose: To report the treatment response of retinoblastoma with vitreous seeds to high-dose chemotherapy coupled with periocular carboplatin.Design: Retrospective, interventional case series.Participants: Consecutive patients with retinoblastoma with vitreous seeds managed over 10 years at a comprehensive ocular oncology center and followed up for at least 12 months after the completion of treatment were included in this study. Institutional review board approval was obtained.Intervention: High-dose chemotherapy with a combination of vincristine, etoposide, and carboplatin in patients with focal vitreous seeds and additional concurrent periocular carboplatin in patients with diffuse vitreous seeds.Main Outcome Measures: Tumor regression, vitreous seed regression, and eye salvage.Results: (Read more...)

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