Evaluation of a thermosensitive atelocollagen punctal plug treatment for dry eye disease – Accepted Manuscript
Abstract: Purpose: To evaluate the efficacy of a thermosensitive atelocollagen punctal plug in the treatment of dry eye disease.Design: Prospective observational case seriesMethods: Thermosensitive atelocollagen punctal plug (Keeptear, Koken Bioscience. Institutes, Japan) was warmed at 37, 39, 41 and 43 °C, to evaluate the appropriate temperature and time for solidification. Dry eye patients were divided into 2 groups according to the preparation method of atelocollagen punctal plug. In the conventional implantation group, atelocollagen gel was kept at room temperature for 15 minutes before implantation (27 eyes of 14 patients). In the pre-heating group, atelocollagen was warmed at 41 °C for (Read more...)