Diagnostic Utility of Adipophilin Immunostain in Periocular Carcinomas – Corrected Proof
Purpose: To determine the efficacy of adipophilin immunohistochemistry in the diagnosis of sebaceous carcinoma of the ocular adnexal region and to provide the guidelines for interpretation of this immunostain.Design: Retrospective, histopathologic case series.Participants: A total of 25 patients with sebaceous carcinoma, 21 patients with basal cell carcinoma, 22 patients with conjunctival squamous cell carcinoma, 9 patients with cutaneous squamous cell carcinoma, and 5 patients with conjunctival mucoepidermoid carcinoma.Methods: Immunohistochemical staining for adipophilin was performed on paraffin-embedded tissues and correlated with hematoxylin–eosin, periodic acid–Schiff (PAS), and mucicarmine-stained preparations. Immunostaining was quantified by light microscopy and with a computerized image analysis system (Read more...)