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Dry eye may be associated with corneal endothelial cell loss
A significant decrease in corneal endothelial cell density was found in eyes with moderate to severe dry eye disease compared with normal eyes, according to a cross-sectional study.The mean endothelial cell density (ECD) was 2,596 cells/mm2 in 90 eyes of 45 patients in the dry eye disease (DED) group and 2,813 cells/mm2 in the control group of 30 eyes of 15 normal subjects, which translates to an approximately 8% lower endothelial cell density in the dry eye disease group.