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Which DRCR.net protocol has had the biggest impact on your practice?
PointIf I had to pick only one study that has had the biggest impact on my current practice among the many important multicenter randomized clinical trials carried out by DRCR.net, it would be Protocol I. At the time of study, anti-VEGF agents were being used mostly for age-related macular degeneration, and focal/grid laser treatment was the standard of care for management of diabetic macular edema. In addition, small studies suggested that intravitreal steroids may be beneficial for DME.