Nicox’s second generation nitric oxide-donating bimatoprost analog NCX 470 met the primary endpoint of non-inferiority compared with latanoprost 0.005% in a dose-ranging study, according to a company press release.
The phase 2 multicenter Dolomites trial, which encompassed 433 patients with open-angle glaucoma or ocular hypertension, found NCX 470 0.065% reduced IOP 7.6 mm Hg to 9.8 mm Hg from baseline at day 28. In the latanoprost group, time-matched IOP was reduced 6.3 mm Hg to 8.8 mm Hg.
“If these results are confirmed in phase 3 clinical trials, NCX 470 (Read more...)
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