We appreciate the interest and comments on our recently published manuscript, “Clinical and Microbiological Profile of Post-Penetrating Keratoplasty Infectious Keratitis in Failed and Clear Grafts.” In this retrospective analysis, we found that pat…
Author: Am J Ophthalmol
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We had proposed the short-term external buckling with pneumatic retinopexy as a novel and effective treatment for rhegmatogenous retinal detachment (RRD) with inferior retinal breaks, with a comparable success rate to other treatment methods.
Clinical and Microbiological Profile of Post-Penetrating Keratoplasty Infectious Keratitis in Failed and Clear Grafts
In their recent article, Constantinou and associates reported clinical outcomes in patients who experienced infectious keratitis after penetrating keratoplasty. Their principal conclusion was that “prolonged use of corticosteroid eye drops is a major…
The Effect of Prior Trabeculectomy on Refractive Outcomes of Cataract Surgery
We read with interest the recent article concerning the refractive outcomes after cataract surgery in patients who had a filtering bleb. We highlight that there is significant uncertainty in regard to refractive outcomes; despite intense research, we…
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We appreciate the interest of Sukhija and associates in our manuscript. They note that intraocular pressure (IOP) has been reported to be lower in infants than adults and for this reason they propose that IOP should be considered to be raised at a lower threshold than >21 mm Hg in children. Although it is probably true that IOP is lower during early infancy, it rises to adult levels during childhood. For this reason, the international standard for pediatric glaucoma studies for a raised IOP continues to be >21 mm Hg. As stated in the Methods section, topical corticosteroids were generally used for 4 weeks after cataract surgery. This steroid regimen adequately controlled postoperative inflammation in these eyes. The only additional intraocular surgeries performed in these eyes were glaucoma surgeries and secondary IOL implantation. Gonioscopy was performed on all of these eyes but was not reported because of space limitations. None of the patients had significant angle-closure issues or a family history of childhood-onset glaucoma. An IOP trend analysis was not performed because of the many uncontrolled variables that can influence IOP in a retrospective study.
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We appreciate the interest of Galvis and associates in our study. We additionally applaud them for doing a surveillance of the local bacterial pathogens encountered in their geographic area. The authors point out the results of the ESCRS endophthalmiti…
Authors May Select Immediate Open Access to Their Articles
We all receive tabloids, mailings, and unsolicited or spam e-mails that intend to provide free information to either a large or sometimes a selective registered audience; some of this content has an advertising objective, but some content clearly has a…
Ultrasound Biomicroscopy of the Ciliary Body in Ocular/Oculodermal Melanocytosis
We read with great interest and attention the recent article from Velazquez-Martin and associates regarding the evaluation of ciliary body thickness in eyes of patients with unilateral ocular/oculodermal melanocytosis. They concluded that ciliary body …
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We appreciate the interest shown in our article. We agree that the Wilcoxon signed-rank test would be more appropriate. We have run the data using this test and have found that the results are statistically significantly consistent with the results usi…
Restricting Topical Ocular Chloramphenicol Eye Drop Use in the United States. Did We Overreact?
Topical ocular chloramphenicol eye drops are relatively inexpensive and have broad-spectrum coverage of most gram-positive, gram-negative, and anaerobic bacteria. Worldwide, it is estimated that more than 50% of the world use topical chloramphenicol as…
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Long-term Risk of Glaucoma After Congenital Cataract Surgery
We read with great interest the article published by Lambert and associates. They have highlighted a very important complication after pediatric cataract surgery. There are certain issues that need to be addressed. The authors enrolled 62 eyes of 37 pa…
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We appreciate the interest of Carifi and associates in our recent article. They have raised some excellent points regarding the limitations of our study, some of which we acknowledged in the article. Since our study was retrospective and included patie…
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Reporting Visual Acuities
Macular Structure Parameters as an Automated Indicator of Paracentral Scotoma in Early Glaucoma – Corrected Proof
Purpose: To evaluate the predictive ability of macular parameters defined in the significance map created using spectral-domain optical coherence tomography (SD-OCT) for paracentral visual field defects in early glaucoma.Design: Prospective comparative study.Methods: We studied 78 early-glaucomatous eyes of 78 patients, who underwent SD-OCT and standard automated perimetry 10-2. Macular layer parameters included the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) + inner plexiform layer (IPL), and RNFL + GCL + IPL. The minimal distance between the area with abnormal (P < 1%) thickness and foveal center was defined as the shortest distance. A wider area of an abnormally thinned (<1%) region, within either an inferior or a superior hemicircle with a diameter of 6 mm centered at the fovea, was defined as the macular abnormal area. A circumpapillary RNFL parameter was defined in its 36 sectors. Areas under the receiver operating characteristic curves (ROCs) were calculated to discriminate between eyes with (n = 39) and without (n = 39) paracentral visual field defects in the central 5 degrees.Results: Measurement reproducibility was almost perfect in the macular parameters at P < 1% (intraclass correlation, 0.907–0.942). Areas under the ROC were significantly higher (P ≤ 0.01) in the macular parameters (0.870–0.930), including the shortest distance of GCL + IPL/RNFL + GCL + IPL, and the macular abnormal area of RNFL/GCL + IPL/RNFL + GCL + IPL than in the circumpapillary RNFL parameter (0.676). When specificity was fixed at ≥90%, the shortest distance of GCL + IPL (area under the ROC = 0.874) and the macular abnormal area of RNFL (area under the ROC = 0.894) showed sensitivities greater than 50%.Conclusions: Macular structural parameters defined on an SD-OCT significance map may be potentially useful predictors of the presence of paracentral scotoma.
Axis Difference Between Corneal and Internal Astigmatism to Consider for Toric Intraocular Lenses – Corrected Proof
Purpose: To evaluate the axis difference between corneal and internal astigmatism in patients with cataract, because if the axis of corneal astigmatism is opposite to the axis of internal astigmatism, the amount of refractive astigmatism will increase …
Conjunctival Mini-flap Operation for Restrictive Strabismus After Periocular Surgery – Corrected Proof
Purpose: To investigate the effect of conjunctival mini-flap operation to treat restrictive strabismus in patients with diplopia caused by conjunctival adhesion and hyperplasia after periocular surgery.Design: Case series study.Methods: Eleven patients…
Intraocular Pressure Fluctuation During Microincision Vitrectomy With Constellation Vision System – Corrected Proof
Purpose: To investigate intraocular pressure (IOP) fluctuation during various vitrectomy maneuvers using the vitrectomy system (Alcon Constellation Vision System).Design: An experimental study as laboratory investigation.Methods: In porcine eyes, 23- a…
Reduction of Retinal Sensitivity in Eyes With Reticular Pseudodrusen – Corrected Proof
Purpose: To evaluate the effect of macular reticular pseudodrusen on retinal function using multiple imaging methods.Design: Prospective cross-sectional study.Methods: Thirteen eyes with reticular pseudodrusen, but without any other macular abnormality or glaucoma, and 20 normal eyes were evaluated. All subjects underwent color fundus photography, infrared reflectance (IR), fundus autofluorescence (FAF), and microperimetry.Results: The similarity in the number of reticular pseudodrusen was evaluated through inter-observer intraclass correlation coefficients, which ranged from 0.852-0.944. IR could detect reticular pseudodrusen within the center circle area in 12 eyes, whereas blue-channel fundus photography and FAF could only detect these lesions in 1 and 3 eyes, respectively. The number of reticular pseudodrusen correlated among the different imaging modalities (P < .001 for all) for all areas of the macula, except the center. The mean retinal sensitivity in eyes with reticular pseudodrusen was lower in all areas of the macula, compared with normal eyes (P < .001 for all). The number of reticular pseudodrusen correlated with retinal sensitivity in all areas by IR imaging (P = .003, P < .001, P = .003 for center, inner ring, outer ring, respectively), in the inner and outer rings by blue-channel fundus photography (P < .001 for both), and in the inner and outer rings by FAF (P < .001 and P = .001, respectively).Conclusions: Although multiple imaging modalities are capable of quantifying reticular pseudodrusen, IR appears to have the best ability to do so as compared to blue-channel photography and FAF. The distribution and number of reticular pseudodrusen lesions are closely associated with retinal sensitivity.