Author: Am J Ophthalmol

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We appreciate Dr Kishore’s interest in our recently published manuscript. He questioned the use of bevacizumab (1.25 mg/0.05 mL; Avastin; Genentech Inc, San Francisco, California, USA) for the treatment of subfoveal hemorrhage secondary to retinal arte…

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We appreciate the interest and comments on our article. The spectral-domain optical coherence tomography (SD OCT) scan image from a 64-year-old woman in Figure 2 might be similar to adult-onset vitelliform dystrophy. However, the final diagnosis was m…

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Reporting Visual Acuities

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The AJO encourages authors to report the visual acuity in the manuscript using the same nomenclature that was used in gathering the data provided they were recorded in one of the methods listed here. This table of equivalent visual acuities is provided…

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Effect of nepafenac eye drops on intraocular pressure – a randomized prospective study – Accepted Manuscript

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Abstract: Purpose: To report the effect of nepafenac (0.1%) eye drops on intraocular pressure in eyes with cataract.Design: Prospective, randomized clinical trial.Methods: Three hundred and twenty-seven patients with bilateral cataracts in an institutional setting were included. All patients had a baseline intraocular pressure (IOP) ≤21 mmHg without a history of intraocular surgery in past 3 months. One eye of each individual was randomized to the treatment group with the other eye acting as a control. Nepafenac (0.1%) eye drops were instilled 3 times a day in the eye that received treatment. Intraocular pressure (IOP) with Goldmann applanation tonometer (GAT) was measured at baseline, 4 and 8 weeks. Proportion of eyes with an IOP elevation of > 4 mmHg was the main outcome measure.Results: The mean age of the participants was 45.7±4.4 years which included 192 females and 135 males. The mean IOP at baseline in the treated and control eyes was 13.8±2.5 and 13.4±3.0 mmHg which reduced to 12.0±2.0 and 12.1±1.5 mmHg at the end of 8 weeks respectively. This reduction in IOP in both groups was significant (p<0.01). The difference between the IOP in the treated and control eyes at 8 weeks was not statistically significant (p=0.34). One eye in the treated group and 2 eyes in the control group had an IOP elevation of > 4 mmHg.Conclusion: Nepafenac eye drops do not increase the IOP. They can possibly be used as an alternative to steroid medications where steroid responsiveness is a concern.

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Comparison of Hoffer Q and Haigis Formulae for Intraocular Lens Power Calculation according to the Anterior Chamber Depth in Short Eyes – Accepted Manuscript

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Abstract: Purpose: To compare the accuracy of the Hoffer Q and Haigis formulae according to the anterior chamber depth (ACD) in cases of short axial length (AL).Design: Retrospective cross-sectional studyMethods: A total of 75 eyes from 75 patients with an AL of less than 22.0 mm implanted with an Acrysof IQ intraocular lens (IOL) were enrolled. The median absolute errors (MedAEs) predicted by the Hoffer Q and Haigis formulae were compared. The correlations between ACD and the predicted refractive error calculated using the two formulae were analyzed.Results: There were no significant differences in the MedAEs predicted by the Hoffer Q and Haigis formulae (0.40 and 0.40 D, respectively). The difference between the refractive errors predicted by the Hoffer Q and Haigis formulae increased significantly as the ACD decreased (R2=0.644, P<.001). The MedAE predicted by the Haigis formula (0.40 D) was significantly smaller than that predicted by the Hoffer Q formula (0.66 D) in eyes with an ACD of less than 2.40 mm (P=.027). There were no significant differences found between the MedAEs predicted by the Hoffer Q and Haigis formulae in eyes with an ACD of 2.40 mm or more.Conclusions: The differences between the predicted refractive errors of the Hoffer Q and Haigis formula increased as ACD decreased in short eyes. Therefore, ACD should be taken into consideration when evaluating the accuracy of the IOL power calculation formulae in short eyes.

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Effect of scan quality on diagnostic accuracy of spectral domain optical coherence tomography in glaucoma – Accepted Manuscript

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Abstract: Purpose: To evaluate the effect of scan quality on the diagnostic accuracies of optic nerve head (ONH), retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) parameters of spectral domain optical coherence tomography (SD-OCT) in glaucoma.Design: Cross-sectional study.Methods: 252 eyes of 183 control subjects (mean MD: -1.84 dB) and 207 eyes of 159 glaucoma patients (mean MD: -7.31 dB) underwent ONH, RNFL and GCC scanning with SD-OCT. Scan quality of SD-OCT images was based on signal strength index (SSI) values. Influence of SSI on diagnostic accuracy of SD-OCT was evaluated by receiver operating characteristic (ROC) regression.Results: Diagnostic accuracies of all SD-OCT parameters were better when the SSI values were higher. This effect was statistically significant (p<0.05) for ONH and RNFL but not for GCC parameters. In mild glaucoma (MD of -5 dB), area under ROC curve (AUC) for rim area, average RNFL thickness and average GCC thickness parameters improved from 0.651, 0.678 and 0.726, at a SSI value of 30 to 0.873, 0.962 and 0.886, respectively at a SSI of 70. AUCs of the same parameters in advanced glaucoma (MD of -15 dB) improved from 0.747, 0.890 and 0.873, at a SSI value of 30 to 0.922, 0.994 and 0.959, respectively at a SSI of 70.Conclusion: Diagnostic accuracies of SD-OCT parameters in glaucoma were significantly influenced by the scan quality even when the SSI values were within the manufacturer recommended limits. These results should be considered while interpreting the SD-OCT scans for glaucoma.

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