Purpose: To evaluate the performance of corneal hysteresis (CH), corneal resistance factor, and 16 investigator-derived Ocular Response Analyzer (ORA) variables in distinguishing keratoconus (KC) from the nondiseased state.Design: Retrospective case series.Participants: Fifty-four eyes of 27 unaffected patients and 49 eyes of 25 KC patients from the Instituto de Olhos, Rio de Janeiro, Brazil.Methods: Sixteen candidate variables were derived from exported ORA signals to characterize putative indicators of biomechanical behavior. Area under the receiver operating characteristic curve (AUC) and the Z statistic were used to compare diagnostic performance.Main Outcome Measures: Discriminant value of standard and derived ORA variables as measured by (Read more...)
Category: Peer-reviewed
Achieving Target Refraction after Cataract Surgery – Corrected Proof
Purpose: To evaluate the difference between target and actual refraction after phacoemulsification and intraocular lens implantation at an academic teaching institution’s Comprehensive Ophthalmology Service.Design: Retrospective study.Participants: We …
Lifitegrast Ophthalmic Solution 5.0% for Treatment of Dry Eye Disease: Results of the OPUS-1 Phase 3 Study – Corrected Proof
Purpose: To assess the efficacy and safety of lifitegrast ophthalmic solution 5.0% compared with placebo in subjects with dry eye disease.Design: Prospective, randomized, double-masked, placebo-controlled, parallel arm, multicenter clinical trial.Participants: A total of 588 adult subjects with dry eye disease.Methods: Eligible subjects were randomized 1:1 to receive topically administered lifitegrast (5.0%) or placebo (vehicle) twice daily for 84 days after a 14-day open-label placebo run-in period. After enrollment (day 0), subjects were evaluated at days 14, 42, and 84. Key objective (fluorescein and lissamine staining scores [Ora scales]) and subjective (Ocular Surface Disease Index [OSDI], 7-item visual analog scale, and ocular (Read more...)
Predicting Progression of Glaucoma from Rates of Frequency Doubling Technology Perimetry Change – Corrected Proof
Purpose: To evaluate the ability of longitudinal frequency doubling technology (FDT) to predict the development of glaucomatous visual field loss on standard automated perimetry (SAP) in glaucoma suspects.Design: Prospective, observational cohort study.Participants: The study included 587 eyes of 367 patients with suspected glaucoma at baseline selected from the Diagnostic Innovations in Glaucoma Study (DIGS) and the African Descent and Glaucoma Evaluation Study (ADAGES). These eyes had an average of 6.7±1.9 FDT tests during a mean follow-up time of 73.1±28.0 months.Methods: Glaucoma suspects had intraocular pressure (IOP) >21 mmHg or an optic disc appearance suspicious of glaucoma. All patients had normal (Read more...)
Systemic Complement Inhibition with Eculizumab for Geographic Atrophy in Age-Related Macular Degeneration: The COMPLETE Study – Corrected Proof
Purpose: To evaluate the effect of eculizumab, a systemic inhibitor of complement component (C5), on the growth of geographic atrophy (GA) in patients with age-related macular degeneration (AMD).Design: Prospective, double-masked, randomized clinical t…
Combined photodynamic therapy with intravitreal bevacizumab injections for polypoidal choroidal vasculopathy: long-term visual outcome – Accepted Manuscript
Abstract: Purpose: To evaluate the long-term visual outcome after combination therapy of photodynamic therapy (PDT) with intravitreal bevacizumab injections for polypoidal choroidal vasculopathy (PCV).Design: Retrospective, observational study.Methods:…
Deep Anterior Lamellar Keratoplasty Using Fresh versus Cryopreserved Corneas – Corrected Proof
Deep anterior lamellar keratoplasty (DALK) requires less stringent criteria for donor tissue quality, which is important in countries with a shortage of donor corneas. Long-term corneal preservation was initially introduced to protect the living endoth…
Adaptive Optics Imaging shows Rescue of Macula Cone Photoreceptors – Corrected Proof
Advanced age-related macular degeneration and inherited macular diseases remain largely untreatable. Clinical trials using stem cell transplantation have recently commenced and mark a further step in introducing cellular therapy for these diseases. Ear…
Outcomes of Upper Eyelid Reconstruction – Corrected Proof
Although numerous operative options are available, upper eyelid reconstruction is often challenging. The reconstructive process needs to ensure that the structure and function of the upper eyelid are maintained to prevent complications, such as a sigh…
Low-Fluence Photodynamic Therapy versus Ranibizumab for Chronic Central Serous Chorioretinopathy: One-Year Results of a Randomized Trial – Corrected Proof
Purpose: To compare the efficacy and safety between low-fluence photodynamic therapy (PDT) and the intravitreal ranibizumab in the treatment of chronic central serous chorioretinopathy (CSC).Design: Prospective, randomized, single-center, parallel-arm, controlled trial.Participants: Thirty-four eyes of 32 patients with chronic CSC with >6 months’ duration of symptoms or recurrent CSC were randomly placed into the low-fluence PDT group (n = 18) or the ranibizumab group (n = 16).Intervention: The patients underwent a single session of low-fluence PDT or 3 consecutive monthly injections of ranibizumab. Rescue treatment was available from month 3 if the subretinal fluid (SRF) persisted or recurred after primary treatment; low-fluence PDT (Read more...)
Sulcus Fixation of a 3-Piece Diffractive Multifocal Intraocular Lens with and without Optic Capture in the Anterior Capsulorhexis – Corrected Proof
Complications during cataract surgery, for example, posterior capsule tear, may prevent intraocular lens (IOL) fixation in the capsular bag. However, the IOL may still be placed in the ciliary sulcus if there was sufficient anterior capsular support.
Improvement From No Light Perception after Orbital Decompression for Optic Neuropathy – Corrected Proof
Compressive optic neuropathy (CON) is among the most severe complications of thyroid eye disease (TED). Orbital decompression has proved to be an effective treatment modality to prevent blindness in TED. Indications for orbital decompression in thyroid…
A Multivitamin Supplement and Cataract and Age-Related Macular Degeneration in a Randomized Trial of Male Physicians – Corrected Proof
Purpose: To test whether long-term multivitamin supplementation affects the incidence of cataract or age-related macular degeneration (AMD) in a large cohort of men.Design: Randomized, double-blind, placebo-controlled trial.Participants: A total of 14
Resident and Fellow Participation in Strabismus Surgery: Effect of Level of Training and Number of Assistants on Operative Time and Cost – Corrected Proof
Objective: To investigate the effect of the level of training and number of assistants on operative time for uncomplicated, 2-muscle, horizontal strabismus surgery at an academic institution.Design: Comparative case series.Participants: A total of 993 …
Author reply – Corrected Proof
Esmaeli’s request for clarification of issues regarding our study involves 11 points related to both the intra-arterial cytoreductive chemotherapy (IACC) protocol design and our analysis. First, the introductory quotation attributed to us was not a sta…
Does Intra-arterial Chemotherapy Improve Survival for Lacrimal Gland Adenoid Cystic Carcinoma? – Corrected Proof
Tse et al summarize the long-term outcomes in 19 patients with adenoid cystic carcinoma of lacrimal gland who underwent treatment on an investigational protocol that entailed receiving intra-arterial chemotherapy (IAC) followed by orbital exenteration…
Is There Risk of Stroke with Aflibercept? – Corrected Proof
The VIEW 1 and 2 studies have shown that aflibercept is an effective treatment for neovascular age-related macular degeneration, but does it come at a cost of an increased risk of stroke?
Retinal Layer Segmentation in Patients with Multiple Sclerosis Using Spectral Domain Optical Coherence Tomography – Corrected Proof
Purpose: To evaluate the thickness of the 10 retinal layers in the paramacular area of patients with multiple sclerosis (MS) compared with healthy subjects using the new segmentation technology of spectral domain optical coherence tomography (OCT). To examine which layer has better sensitivity for detecting neurodegeneration in patients with MS.Design: Observational, cross-sectional study.Participants: Patients with MS (n = 204) and age-matched healthy subjects (n = 138).Methods: The Spectralis OCT system (Heidelberg Engineering, Inc., Heidelberg, Germany) was used to obtain automated segmentation of all retinal layers in a parafoveal scan in 1 randomly selected eye of each participant, using the new segmentation application (Read more...)
Unilateral Partial Limbal Stem Cell Deficiency: Contralateral versus Ipsilateral Autologous Cultivated Limbal Epithelial Transplantation – Accepted Manuscript
Abstract: Purpose: To report the outcomes of autologous cultivated limbal epithelial transplantation utilizing the healthy part of the affected eye or the fellow eye as a source of limbal stem cells in patients with unilateral, partial limbal stem cell…
Management Paradigms for Diabetic Macular Edema – Accepted Manuscript
Abstract: Purpose: To provide evidence-based recommendations for diabetic macular edema (DME) management based on updated information from publications on DME treatment modalities.Design: Perspective.Methods: A literature search for “diabetic macular…