Category: Peer-reviewed

The p53 Codon 72 Polymorphism (rs1042522) Is Associated with Proliferative Vitreoretinopathy: The Retina 4 Project

Purpose:
To compare the distribution of a p53 gene polymorphism among European subjects undergoing primary retinal detachment (RD) surgery in relation to the development of proliferative vitreoretinopathy (PVR).

Design:
Case-controlled gene association study conducted as a component of the Retina 4 Project (a European multicenter study).

Participants and Controls:
Five hundred fifty DNA samples, 134 with PVR secondary to primary RD and 416 with RD without PVR.

Methods:
The p53 codon 72 polymorphism (rs1042522) was analyzed using allele-specific primer polymerase chain reaction. Proportions of genotypes and the proline (Pro-P) homozygote (Read more...)

Cost-Effectiveness of Descemet’s Stripping Endothelial Keratoplasty versus Penetrating Keratoplasty

Purpose:
Selective endothelial transplantation in the form of Descemet’s stripping endothelial keratoplasty (DSEK) is rapidly replacing traditional full-thickness penetrating keratoplasty (PK) for endothelial disease. An incremental cost-effectiveness analysis was performed to determine whether the benefits of DSEK are worth the additional costs.

Design:
Retrospective cohort study.

Participants:
Patients at the Singapore National Eye Center, a tertiary eye center in Singapore, with Fuchs’ dystrophy or bullous keratopathy who underwent either PK or DSEK.

Intervention:
Patients underwent either PK (n = 171) or DSEK (n = 93) from January 2001 through December (Read more...)

Corneal Thickness in Keratoconus: Comparing Optical, Ultrasound, and Optical Coherence Tomography Pachymetry

Purpose:
To compare the central and peripheral pachymetry measurements determined using Orbscan IIz (Bausch & Lomb, Rochester, NY), Visante optical coherence tomography (OCT; Carl Zeiss Meditec, Dublin, CA), and RTVue OCT (Oculus Technologies, Wynwood, WA) with ultrasound pachymetry in eyes with established keratoconus and to evaluate the agreement between them.

Design:
Evaluation of diagnostic technologies.

Participants:
One hundred six eyes of 67 consecutive patients with a clinical diagnosis of keratoconus ranging in age from 12 to 40 years.

Methods:
Central corneal thickness (CCT) was determined by all the 4 techniques. (Read more...)

Associations of Anisometropia with Unilateral Amblyopia, Interocular Acuity Difference, and Stereoacuity in Preschoolers

Purpose:
To evaluate the relationship of anisometropia with unilateral amblyopia, interocular acuity difference (IAD), and stereoacuity among Head Start preschoolers using both clinical notation and vector notation analyses.

Design:
Multicenter, cross-sectional study.

Participants:
Three- to 5-year-old participants in the Vision in Preschoolers (VIP) study (n = 4040).

Methods:
Secondary analysis of VIP data from participants who underwent comprehensive eye examinations, including monocular visual acuity testing, stereoacuity testing, and cycloplegic refraction. Visual acuity was retested with full cycloplegic correction when retest criteria were met. Unilateral amblyopia was defined as IAD of (Read more...)

Progression Pattern of Initial Parafoveal Scotomas in Glaucoma

Objective:
To characterize the progression pattern of initial parafoveal scotomas (IPFSs) using cross-sectional and longitudinal 10-2 visual field (VF) data.

Design:
Retrospective, observational study.

Participants:
Glaucoma patients with an IPFS in either hemifield based on 2 reliable 24-2 Swedish interactive threshold algorithm standard VFs (≥3 adjacent points with P<0.05 within the central 10° of fixation, 1 point or more with P<0.01 lying at the innermost paracentral points, and no scotoma outside the central 10°) and at least 2 10-2 VFs (first and last VFs 1 year or more apart).

Methods:
(Read more...)