Peer-reviewed

Evaluation of a thermosensitive atelocollagen punctal plug treatment for dry eye disease – Accepted Manuscript

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Abstract: Purpose: To evaluate the efficacy of a thermosensitive atelocollagen punctal plug in the treatment of dry eye disease.Design: Prospective observational case seriesMethods: Thermosensitive atelocollagen punctal plug (Keeptear, Koken Bioscience. Institutes, Japan) was warmed at 37, 39, 41 and 43 °C, to evaluate the appropriate temperature and time for solidification. Dry eye patients were divided into 2 groups according to the preparation method of atelocollagen punctal plug. In the conventional implantation group, atelocollagen gel was kept at room temperature for 15 minutes before implantation (27 eyes of 14 patients). In the pre-heating group, atelocollagen was warmed at 41 °C for (Read more...)

Peer-reviewed

Optic disc planimetry, corneal hysteresis, central corneal thickness and intraocular pressure as risk factors for glaucoma – Accepted Manuscript

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Abstract: Purpose: To determine whether corneal hysteresis and central corneal thickness are independent risk factors for glaucoma.Design: This was a cross-sectional population based cohort study.Methods: Associations were tested between corneal hysteresis, measured in 1754 population-based subjects from the TwinsUK cohort, and glaucoma-related endophenotypes, including intraocular pressure (IOP), vertical cup to disc ratio, optic disc area and optic disc cup area. Corneal hysteresis, IOP and Central Corneal Thickness (CCT) were measured using the Ocular Response Analyser (ORA-Reichert® Buffalo, NY). Optic disc photographs were analysed using the Stereo DX program. Multivariable linear regression analysis was performed using STATA software.Results: Data was available (Read more...)

Peer-reviewed

Corneal changes in Xeroderma Pigmentosum: a clinicopathological Report – Accepted Manuscript

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Abstract: Purpose: To report the clinicopathological features of corneal involvement in patients with Xeroderma pigmentosum.Design: Retrospective review of corneal histopathology.Methods: Thirteen corneal specimens of 11 patients with Xeroderma pigmentosum who underwent keratoplasty (lamellar/full- thickness) for corneal involvement were studied. Five microns thick sections were made from all the samples and stained using Hematoxylin & Eosin (H & E) and Periodic Acid Schiff (PAS) stains. A light microscopic examination was performed to study the histopathological changes.Results: The corneal findings on clinical examination were haze, scarring, vascularization, stromal edema, pigment clumps on endothelial surface and corneal thinning. The histopathological evaluation revealed changes (Read more...)