The REPAIR study was a phase II, prospective, multicenter, industry-sponsored study (clinical trial registration: http://clinicaltrials.gov/; identifier: NCT01037348) of intravitreal ranibizumab in myopic choroidal neovascularization (CNV). The purpose…
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We would like to thank Galvis et al for their comments on our article. It has been demonstrated by us that the sensitivity of potassium hydroxide (KOH) in detecting fungal elements was 94.3%. This has also been substantiated by other authors who repor…
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We thank Matonti et al for their interest in our study (SECURE). Matonti et al mention in their letter that the mean BCVA decrease of 4.3 letters from baseline observed in the SECURE study may be owing to retinal nerve fiber layer (RNFL) decrease and…
Cyclosporine A Drug-Delivery System for High-risk Keratoplasty
We read the article by Shi et al reporting the efficacy of a novel cyclosporine (CsA) drug delivery system (DDS) for suppressing the occurrence of rejection and improving the survival of corneal allografts after high-risk keratoplasty with great inter…
Fluoroquinolones in Corneal Ulcers
We read with interest the article by Sharma et al on moxifloxacin 0.5% in treatment of corneal ulcers. Authors indicated that corneal scrapings were examined using the Gram stain and potassium hydroxide wet mount, and that any case showing fungal elem…
Retinal Ganglion Cell Analysis in Leber’s Hereditary Optic Neuropathy
Leber’s hereditary optic neuropathy (LHON) is a rare, maternally inherited disorder that results in bilateral loss of central vision. Characteristic visual field defects in LHON consist of either central or cecocentral scotomas, with about 70% of the patients being young adult men. More than 90% of these patients carry 1 of 3 mitochondrial DNA (mtDNA) mutations, located at nucleotide positions 3460, 11778, or 14484, respectively, although >20 mtDNA point mutations have been reported in LHON patients worldwide. Retinal ganglion cells decrease by apoptosis, and finally the retinal nerve fiber thins (Read more...)