Peer-reviewed

American Joint Committee on Cancer Classification of Posterior Uveal Melanoma (Tumor Size Category) Predicts Prognosis in 7731 Patients – Corrected Proof

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Purpose: To evaluate the clinical features and prognosis of posterior uveal (ciliary body and choroid) melanoma based on the American Joint Committee on Cancer (AJCC) classification (7th edition) of primary tumor (T).Design: Retrospective, interventional case series.Participants: Seven thousand seven hundred thirty-one patients.Intervention: Ocular management including plaque radiotherapy, enucleation, local resection, or laser therapy.Main Outcome Measures: Melanoma-related metastasis and death.Results: Of 7731 patients with posterior uveal melanoma, the AJCC classification based on T was category T1 in 3557 (46%), T2 in 2082 (27%), T3 in 1599 (21%), and T4 in 493 (6%). Based on tumor categories T1, T2, T3, and T4, respectively, (Read more...)

Peer-reviewed

Correction of Visual Impairment by Cataract Surgery and Improved Survival in Older Persons: The Blue Mountains Eye Study Cohort – Corrected Proof

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Objective: We assessed whether correction of visual impairment (VI) by cataract surgery was associated with improved long-term survival in an older Australian population.Design: Population-based cohort study.Participants: In the Blue Mountains Eye Study, 354 participants, aged ≥49 years, had both cataract and VI or had undergone cataract surgery before baseline examinations. They were subsequently examined after 5- and 10-year follow-ups.Methods: Associations between the mortality risk and the surgical correction of VI (visual acuity [VA] <20/40, attributable to cataract) were assessed in Cox proportional hazard regression models, after multivariate adjustment, using time-dependent variables for the study factor.Main Outcome Measures: All-cause mortality.Results: The (Read more...)

Peer-reviewed

Ocular Demodicosis as a Risk Factor of Pterygium Recurrence – Corrected Proof

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Purpose: To evaluate ocular demodicosis as a potential risk factor in pterygium recurrence.Design: Cross-sectional study to correlate clinical findings with laboratory data.Participants: We retrospectively reviewed 94 patients (43 with primary and 51 with recurrent pterygia), among whom 68 patients received surgical correction, and prospectively enrolled another 23 pterygium patients and 14 nonpterygium controls for measuring the tear level of interleukin (IL)-17.Methods: All patients had microscopically confirmed ocular demodicosis. Statistical correlations were analyzed among age, sex, aqueous tear deficiency, dry eye, ocular demodicosis, follow-up period, surgical outcome, and tear levels of IL-17 measured by enzyme-linked immunosorbent assay.Main Outcome Measures: Correlation between (Read more...)