Peer-reviewed

American Joint Committee on Cancer Classification of Posterior Uveal Melanoma (Tumor Size Category) Predicts Prognosis in 7731 Patients – Corrected Proof

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Purpose: To evaluate the clinical features and prognosis of posterior uveal (ciliary body and choroid) melanoma based on the American Joint Committee on Cancer (AJCC) classification (7th edition) of primary tumor (T).Design: Retrospective, interventional case series.Participants: Seven thousand seven hundred thirty-one patients.Intervention: Ocular management including plaque radiotherapy, enucleation, local resection, or laser therapy.Main Outcome Measures: Melanoma-related metastasis and death.Results: Of 7731 patients with posterior uveal melanoma, the AJCC classification based on T was category T1 in 3557 (46%), T2 in 2082 (27%), T3 in 1599 (21%), and T4 in 493 (6%). Based on tumor categories T1, T2, T3, and T4, respectively, (Read more...)

Peer-reviewed

Correction of Visual Impairment by Cataract Surgery and Improved Survival in Older Persons: The Blue Mountains Eye Study Cohort – Corrected Proof

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Objective: We assessed whether correction of visual impairment (VI) by cataract surgery was associated with improved long-term survival in an older Australian population.Design: Population-based cohort study.Participants: In the Blue Mountains Eye Study, 354 participants, aged ≥49 years, had both cataract and VI or had undergone cataract surgery before baseline examinations. They were subsequently examined after 5- and 10-year follow-ups.Methods: Associations between the mortality risk and the surgical correction of VI (visual acuity [VA] <20/40, attributable to cataract) were assessed in Cox proportional hazard regression models, after multivariate adjustment, using time-dependent variables for the study factor.Main Outcome Measures: All-cause mortality.Results: The (Read more...)