Author: Am J Ophthalmol

Comparison and Repeatability of Keratometric and Corneal Power Measurements Obtained by Orbscan II, Pentacam, and Galilei Corneal Tomography Systems – Corrected Proof

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Purpose: To assess the repeatability and comparability of corneal power and central corneal thickness (CCT) measurements obtained using Orbscan II (Bausch & Lomb), Pentacam (Oculus), and Galilei (Ziemer) tomographers.Design: Prospective, comparative study.Methods: setting: Departments of Ophthalmology, University of Auckland and Auckland District Health Board, Auckland, New Zealand. study population: Thirty eyes of 30 healthy participants. observations. CCT and corneal power measured using Orbscan II, Pentacam, and Galilei tomography. main outcome measures: Degree of agreement in and repeatability of CCT and corneal power measures.Results: Orbscan II measured significantly lower CCT compared with Pentacam (20 μm; P < .0005) and Galilei (18 μm; P (Read more...)

Foveal Thickness in Healthy Fellow Eyes of Patients With Unilateral Macular Holes – Corrected Proof

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Purpose: To compare the morphologic parameters of ophthalmoscopically and tomographically normal foveae of the fellow eyes of patients with a unilateral macular hole (MH), other unilateral retinal diseases, and healthy eyes.Design: Observational, cross-sectional study.Methods: Of the 849 subjects studied, 183 eyes were excluded because they had an abnormal vitreofoveal interface that might have affected the foveal thickness. The average regional retinal thicknesses of the Early Treatment Diabetic Retinopathy Study sectors determined by spectral-domain optical coherence tomography were compared among 160 patients with MH, 175 patients with epiretinal membrane, 145 patients with retinal vein occlusion, and 186 healthy subjects. The foveal depression (Read more...)

Morphologic Characteristics of Optic Nerve Head Drusen on Spectral-Domain Optical Coherence Tomography – Corrected Proof

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Purpose: To evaluate the morphologic characteristics of optic nerve head drusen.Design: Retrospective case series.Methods: Setting: Institutional (Seoul National University Bundang Hospital). Patients: Sixty-one patients with optic nerve head drusen. Observation procedure: Visible and buried optic nerve head drusen were identified using funduscopy, whereas homogenous and nonhomogenous optic nerve head drusen were identified using spectral-domain optical coherence tomography images. Buried optic nerve head drusen were classified according to the size. Main Outcome Measures: Classification of optic nerve head drusen.Results: Of 99 eyes in 61 patients, optic nerve head drusen were buried in 95 eyes and visible in 4 eyes. The patients (Read more...)

Endothelial Keratoplasty: Prospective, Randomized, Masked Clinical Trial Comparing an Injector With Forceps for Tissue Insertion – Corrected Proof

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Purpose: To compare the complications and outcomes of Descemet stripping automated endothelial keratoplasty (DSAEK) when the tissue is either folded and inserted with a forceps or inserted using a platform injector device without folding.Design: Prospective, randomized, masked clinical trial.Methods: DSAEK was performed in 100 eyes of 79 patients undergoing DSAEK surgery for Fuchs corneal dystrophy. Fifty eyes were randomized to have the donor tissue inserted with Charlie II insertion forceps (Bausch & Lomb Surgical) and 50 eyes were randomized to have the donor tissue inserted with the Neusidl Corneal Inserter (Fischer Surgical Inc). All other steps of the surgical procedure were (Read more...)

Myopia-Related Fundus Changes in Singapore Adults With High Myopia – Corrected Proof

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Purpose: To examine the pattern of myopia-related macular and optic disc changes in Singapore adults with high myopia (spherical equivalent ≤−6.00 diopters).Design: Asian adults with high myopia from 3 population-based surveys.Methods: Adults 40 years and older (n = 359) with high myopia were pooled from 3 population-based surveys in Singapore Asians: (1) the Singapore Prospective Study Program (SP2, n = 184); (2) the Singapore Malay Eye Study (SiMES, n = 98); and (3) the Singapore Indian Eye Study (SINDI, n = 77). All study participants underwent standardized refraction and fundus photography, and SiMES and SINDI subjects also completed ocular biometry measurements. Myopia-related macular (posterior (Read more...)

A Longitudinal Study of Stargardt Disease: Clinical and Electrophysiologic Assessment, Progression, and Genotype Correlations – Corrected Proof

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Purpose: To investigate the clinical and electrophysiologic natural history of Stargardt disease and correlate with the genotype.Design: Cohort study of 59 patients.Methods: Clinical history, examination, and electrophysiologic assessment were undertaken in a longitudinal survey. Patients were classified into 3 groups based on electrophysiologic findings, as previously published: Group 1 had dysfunction confined to the macula; Group 2 had macular and generalized cone system dysfunction; and Group 3 had macular and both generalized cone and rod system dysfunction. At baseline, there were 27 patients in Group 1, 17 in Group 2, and 15 in Group 3. Amplitude reduction of >50% in (Read more...)

Displacement of the Retina and Its Recovery After Vitrectomy in Idiopathic Epiretinal Membrane – Corrected Proof

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Objective: To study the displacement of the retina and its change after vitrectomy in idiopathic epiretinal membrane (ERM).Design: Prospective, interventional case series.Methods: Fifty-six eyes of 53 consecutive patients with ERM underwent vitrectomy with ERM removal and internal limiting membrane peeling. Fundus autofluorescence (FAF) imaging was examined before and at 1, 3, 6, and 12 months after vitrectomy. Main outcome measures were the proportion of eyes with retinal displacement for ERM detected by FAF imaging and the recovery rate of retinal displacement after vitrectomy.Results: Before surgery, FAF photography demonstrated hyperautofluorescent lines within the vascular arcade in 37 (66.1%) of the 56 eyes. (Read more...)

The Rate of Structural Change: The Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study – Corrected Proof

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Purpose: To compare rates of topographic change in ocular hypertensive eyes in which primary open-angle glaucoma (POAG) does or does not develop, and to identify factors that influence the rate of change.Design: Longitudinal, randomized clinical trial.Methods: Four hundred forty-one participants (832 eyes) in the Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study were included. POAG was defined as repeatable visual field, photography-based optic disc changes, or both. The rate of topographic change in the 52 participants (66 eyes) who developed POAG was compared with that of participants who did not develop POAG using multivariable mixed effects (Read more...)

Meibomian Gland Morphology in Japanese Infants, Children, and Adults Observed Using a Mobile Pen-shaped Infrared Meibography Device – Corrected Proof

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Purpose: To compare meibomian gland morphology between children and adults.Design: Cross-sectional, observational case series.Methods: In an institutional setting, healthy pediatric (n = 78, 30 boys, 48 girls; mean age ± standard deviation, 4.1 ± 3.4 years; range 1 month – 12 years) and adult (n = 25, 11 men, 14 women; 31.3 ± 4.8 years; range 24-39 years) volunteers participated in the study. A noninvasive mobile pen-shaped infrared meibography device was used to observe the meibomian glands. Lost meibomian gland area (meiboscore) was scored from grade 0 (no meibomian gland loss) through grade 3 (>two-thirds of the total area lost). The number of meibomian (Read more...)

16 and 24 Gy Low-voltage X-ray Irradiation With Ranibizumab Therapy for Neovascular Age-Related Macular Degeneration: 12-Month Outcomes – Corrected Proof

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Purpose: To describe the 12-month safety and efficacy outcomes of 16 or 24 Gy radiation using low-voltage x-ray irradiation in conjunction with intravitreal ranibizumab for neovascular age-related macular degeneration (AMD).Design: Prospective, phase I, open-label, nonrandomized uncontrolled safety study.Methods: setting: Institutional. study population: Neovascular AMD patients. intervention: One x-ray irradiation treatment at 16 or 24 Gy was administered externally through 3 locations in the inferior pars plana. After 2 initial monthly loading doses of ranibizumab, subsequent ranibizumab was administered according to predetermined criteria. main outcome measures: Visual acuity, number of ranibizumab injections, safety and efficacy metrics at 12 months.Results: Forty-seven eyes of 47 patients (Read more...)