Purpose: To investigate the association of open-angle glaucoma (OAG), primary open-angle glaucoma (POAG), and pseudoexfoliative glaucoma (PEXG) with ocular perfusion pressure status (ocular perfusion pressure with or without antihypertensive treatment)…
Author: Am J Ophthalmol
Intravitreal Bevacizumab for Symptomatic Retinal Arterial Macroaneurysm – Corrected Proof
Purpose: To evaluate the therapeutic effect of intravitreal bevacizumab injection for symptomatic retinal arterial macroaneurysm.Design: Retrospective interventional case series.Methods: The study included 23 patients (23 eyes) with symptomatic retinal…
Retroprosthetic Membrane and Risk of Sterile Keratolysis in Patients With Type I Boston Keratoprosthesis – Corrected Proof
Purpose: To evaluate whether retro-backplate retroprosthetic membrane is correlated with risk of melt in patients with a type I Boston Keratoprosthesis (KPro).Design: Retrospective, observational case series.Methods: Study of 50 eyes of 47 patients wit…
Angiographic and Optical Coherence Tomography Characteristics of Recent Myopic Choroidal Neovascularization – Corrected Proof
Purpose: To analyze the contribution of fluorescein angiography (FA) and spectral-domain optical coherence tomography (SD OCT) to the diagnosis of recent choroidal neovascularization (CNV) associated with high myopia.Design: Retrospective, observational case series.Methods: Ninety eyes of 73 highly myopic patients (refractive error ≥−6 diopters) with CNV in 1 or both eyes were included. Epidemiologic features, refractive error, fundus examination, fluorescein angiography, and SD OCT findings at onset of CNV were analyzed.Results: Mean age at onset of CNV was 54.4 ± 14 years. CNV was bilateral in 17 of 73 cases. Mean refractive error was −13.9 ± 5.2 diopters. Myopic CNV was associated (Read more...)
High-Resolution Imaging of Retinal Nerve Fiber Bundles in Glaucoma Using Adaptive Optics Scanning Laser Ophthalmoscopy – Corrected Proof
Purpose: To detect pathologic changes in retinal nerve fiber bundles in glaucomatous eyes seen on images obtained by adaptive optics (AO) scanning laser ophthalmoscopy (AO SLO).Design: Prospective cross-sectional study.Methods: Twenty-eight eyes of 28 patients with open-angle glaucoma and 21 normal eyes of 21 volunteer subjects underwent a full ophthalmologic examination, visual field testing using a Humphrey Field Analyzer, fundus photography, red-free SLO imaging, spectral-domain optical coherence tomography, and imaging with an original prototype AO SLO system.Results: The AO SLO images showed many hyperreflective bundles suggesting nerve fiber bundles. In glaucomatous eyes, the nerve fiber bundles were narrower than in normal (Read more...)
Vitreomacular Traction as a Consequence of Posterior Hyaloidal Contraction after Transpupillary Thermotherapy – Corrected Proof
Purpose: To describe the pathogenesis, clinical characteristics, management, and outcomes of patients in whom vitreomacular traction evolved pursuant to treatment of choroidal melanoma with transpupillary thermotherapy.Design: Retrospective, uncontroll…
Comparison of Clinical Characteristics Between Korean and Western Normal-Tension Glaucoma Patients – Corrected Proof
Purpose: To detect potential differences in the phenotypes between Western normal-tension glaucoma (NTG) and Korean NTG.Design: A retrospective, cross-sectional study.Methods: One hundred eighty-four NTG eyes of 71 patients of the Jules Stein Eye Institute, University of California, Los Angeles, and 113 patients of the Seoul National University Hospital, Seoul, Korea, were studied after reviewing medical charts retrospectively. All eligible patients from both institutions who were evaluated between July 2007 and June 2008 were included. The groups were matched for stage of glaucoma severity based on the visual field mean deviation value. All patients underwent a complete ophthalmic examination, Humphrey perimetry, Heidelberg Retina (Read more...)
Vernal Keratoconjunctivitis-like Disease in Adults – Corrected Proof
Purpose: To identify clinical, demographic, immunologic, and health-related quality-of-life data from a cohort of vernal keratoconjunctivitis (VKC) patients with the onset of the disease after puberty (VKC-like disease).Design: Retrospective, observati…
Continuous Corneal Intrastromal Ring Implantation for Treatment of Keratoconus in an Iranian Population – Corrected Proof
Purpose: To evaluate the effect of mechanical implantation of a continuous intrastromal ring in keratoconus.Design: Prospective, interventional, nonrandomized, case series.Methods: The MyoRing (Dioptex GmbH) was implanted after creation of an intrastro…
Comparison of Nylon Monofilament Suture and Polytetrafluoroethylene Sheet for Frontalis Suspension Surgery in Eyes With Congenital Ptosis
Purpose: To compare nylon monofilament suture with polytetrafluoroethylene sheet for frontalis suspension surgery to treat eyes with congenital ptosis.Design: Retrospective, nonrandomized, comparative, interventional case series.Methods: We reviewed the medical records of 49 patients who had undergone 79 eyelid frontalis suspension surgeries to treat congenital ptosis. All of the patients were younger than 16 years and had congenital ptosis with poor levator muscle function. They were treated with frontalis suspension surgery with either a nylon suture or a polytetrafluoroethylene sheet and were followed up for at least 1 year. A single rhomboid loop sling was used for the nylon suture surgery. (Read more...)
Tear Meniscus Evaluation by Anterior Segment Swept-Source Optical Coherence Tomography
Purpose: To investigate the repeatability of tear meniscus measurements using anterior segment swept-source optical coherence tomography (OCT) and the relationship of tear meniscus measurements with tear film breakup time and Schirmer test results.Design: Prospective, observational, cross-sectional study.Methods: We enrolled 26 healthy subjects (26 eyes; 20 men and 6 women; mean age, 36.5 ± 6.8 years) at the University of Tokyo School of Medicine, Tokyo, Japan, in this study. Examinations were conducted in the following sequence: anterior segment vertical raster scans by swept-source OCT, tear film breakup time, and Schirmer test. Each subject underwent OCT measurements twice by the same grader, (Read more...)
Objective Assessment of Crystalline Lens Opacity Level by Measuring Ocular Light Scattering With a Double-Pass System
Purpose: To assess the crystalline lens opacity level by measuring ocular light scattering with a double-pass system.Design: Prospective, single-center, cross-sectional study.Methods: Two hundred fifty-three eyes of 135 patients referred for cataract evaluation were enrolled. Patients with corneal or retinal anomalies potentially impairing ocular transparency were excluded. Lens opacification was assessed by the Lens opacities classification system III. Optical Quality Analysis System (Visiometrics SL) measurements provided ocular Modulation Transfer Function cutoff frequency and Objective Scatter Index. Best-corrected visual acuity and Quality of Vision questionnaire scores (Rasch-scaled) were recorded. We analyzed correlations between visual acuity, type and severity of cataract, Optical Quality (Read more...)
Comparison of Retention Rates and Complications of 2 Different Types of Silicon Lacrimal Punctal Plugs in the Treatment of Dry Eye Disease
Purpose: To investigate the retention rate and complications of 2 different types of silicon lacrimal punctal plugs with the focus on the relationship to punctum size.Design: A prospective, nonrandomized, interventional, comparative study.Method: Forty-four patients with dry eye syndrome received lacrimal punctal plug insertion with the Punctal Plug F (FCI Ophthalmics) and 30 patients received plug insertion with the Super Flex plug (Eagle Vision; Softplug-Oasis Medical Inc). In total, 110 plug insertion regions were performed using the Punctal Plug F (group A) and 110 insertion regions were carried out using Super Flex plug (group B). The gauging system of Eagle Vision (Read more...)
Uncorrected Binocular Performance After Biaspheric Ablation Profile for Presbyopic Corneal Treatment Using AMARIS with the PresbyMAX Module
Purpose: To analyze the uncorrected binocular performance after biaspheric multifocal central presbyopic laser in situ keratomileusis treatments.Design: Retrospective, interventional case series.Methods: setting. Private clinical practice. patient or …
Predictive Value of Spectral-Domain Optical Coherence Tomography Features in Assessment of Visual Prognosis in Eyes With Neovascular Age-Related Macular Degeneration Treated With Ranibizumab
Purpose: To determine whether pretreatment (baseline) optical coherence tomography (OCT) features can be used as predictors of visual acuity outcome at 12 months in eyes with neovascular age-related macular degeneration treated with intravitreal ranibizumab and to assess whether baseline OCT features can predict a change in visual acuity from baseline to 12 months.Design: Retrospective, observational study.Methods: We retrospectively evaluated the serial cross-sectional images of the macula obtained using the Spectralis OCT (HRA+OCT; Heidelberg Engineering) in 100 eyes of 94 patients attending a single center and undergoing treatment with intravitreal ranibizumab for neovascular age-related macular degeneration. The baseline OCT characteristics and visual acuity were (Read more...)
Postoperative Vitreous Hemorrhage After Diabetic 23-Gauge Pars Plana Vitrectomy
Purpose: To report the frequency of postoperative vitreous hemorrhage (VH) in eyes that underwent primary 23-gauge pars plana vitrectomy (PPV) for nonclearing VH resulting from proliferative diabetic retinopathy, as well as associated risk factors.Design: Retrospective, consecutive, interventional case series.Methods: setting: Institutional (Retina Service of Wills Eye Institute). study population: One hundred seventy-three eyes of 157 patients. intervention: Twenty-three–gauge PPV for nonclearing diabetic VH. main outcome measures: Percentage of eyes in which postoperative VH developed, categorized as early, delayed, or severe persistent, as well as percentage requiring reoperation.Results: During a mean follow-up of 32 weeks, 56 (32%) of 173 eyes demonstrated postoperative (Read more...)
Short-Term External Buckling With Pneumatic Retinopexy for Retinal Detachment With Inferior Retinal Breaks
Purpose: To introduce a new approach for short-term external scleral buckling with pneumatic retinopexy for the management of rhegmatogenous retinal detachment with inferior retinal breaks.Design: Retrospective, noncomparative, interventional case series.Methods: A review of 33 consecutive eyes of 31 patients who underwent external buckling with pneumatic retinopexy for uncomplicated rhegmatogenous retinal detachment with inferior retinal breaks from December 2006 through December 2010. An external buckle was made of a 505 sponge sutured along the blunt side of a 279 tyre (MIRA Inc). The buckle was inserted deeply into the inferior fornix without suture after pneumatic retinopexy and was kept in place (Read more...)
Thinner Choroid and Greater Drusen Extent in Retinal Angiomatous Proliferation Than in Typical Exudative Age-Related Macular Degeneration
Purpose: To compare choroidal thickness and extent and density of drusen between eyes with typical exudative age-related macular degeneration (AMD) and eyes with retinal angiomatous proliferation (RAP).Design: Observational case series.Methods: Twenty-four eyes with typical exudative AMD and 20 eyes with RAP were included. Subfoveal choroidal thickness was measured using enhanced depth imaging optical coherence tomography. Eyes were classified into 3 groups according to the extent of drusen distribution in the fundus photograph. Density of drusen was estimated based on optical coherence tomography images of the fellow eye. The proportion of the length beneath the drusen per the entire length of (Read more...)
Macular Pseudoholes With Lamellar Cleavage of Their Edge Remain Pseudoholes
Purpose: To reappraise macular pseudohole characteristics using spectral-domain optical coherence tomography (OCT) and characteristics and postoperative outcomes of macular pseudoholes.Design: Retrospective, observational case series.Methods: In this i…
Combined Depth Imaging Technique on Spectral-Domain Optical Coherence Tomography
Purpose: To describe a technique to obtain combined images of vitreoretinal and choroidal structures using spectral-domain (SD) optical coherence tomography (OCT) and to evaluate applicability in normal eyes and limitations in eyes with cataract.Design: Prospective, observational case series.Methods: Three different foveal scans, including conventional SD OCT, enhanced depth imaging OCT and the novel method called combined depth imaging (CDI) OCT, were obtained in 42 eyes of healthy volunteers and in 26 eyes with cataract using the Heidelberg Spectralis HRA (Heidelberg Engineering). The CDI OCT images were obtained manually using an image modification process that enhances the vitreoretinal interface first and (Read more...)