Abstract: Purpose: To present 4 patients that developed hemorrhagic retinal infarction due to inadvertent overdose of cefuroxime after cataract surgery.Design: Case series.Materials and Methods: Surgery in 4 patients was complicated—the posterior cap…
Author: Am J Ophthalmol
Neoplastic Masquerade Syndromes among Uveitis Patients – Accepted Manuscript
Abstract: Purpose: To identify the demographic and clinical characteristics, along with the frequency, of neoplastic masquerade syndromes in a tertiary uveitis clinic.Design: A retrospective observational cohort.Methods: Demographic and clinical data o…
In Vivo 3-Dimensional Corneal Epithelial Thickness Mapping as an Indicator of Dry Eye: Preliminary Clinical Assessment – Corrected Proof
Purpose: To evaluate in vivo epithelial thickness in dry eye by anterior segment optical coherence tomography.Design: Observational, retrospective case-control study.Methods: Two age-matched groups of female subjects, 70 eyes each, age ≈ 55 years, were studied in clinical practice setting: a control (unoperated, no ocular pathology) and a dry eye group (clinically confirmed dry eye, unoperated and no other ocular pathology). Corneal epithelium over the entire cornea was topographically imaged via a novel anterior segment optical coherence tomography (AS-OCT) system. Average, central, and peripheral epithelial thickness as well as topographic epithelial thickness variability were measured.Results: For the control group, central epithelial thickness was 53.0 ± 2.7 μm (45-59 μm). Average epithelium thickness was 53.3 ± 2.7 μm (46.7-59.6 μm). Topographic thickness variability was 1.9 ± 1.1 μm (0.7-6.1 μm). For the dry eye group, central epithelial thickness was 59.5 ± 4.2 μm (50-72 μm) and average thickness was 59.3 ± 3.4 μm (51.4-70.5 μm). Topographic thickness variability was 2.5 ± 1.5 μm (0.9-6.9 μm). All pair tests of respective epithelium thickness metrics between the control and dry eye group show statistically significant difference (P < .05).Conclusions: This study, based on very user-friendly, novel AS-OCT imaging, indicates increased epithelial thickness in dry eyes. The ease of use and the improved predictability offered by AS-OCT epithelial imaging may be a significant clinical advantage. Augmented epithelial thickness in the suspect cases may be employed as an objective clinical indicator of dry eye.
Correlation of the Corneal Collagen Cross-Linking Demarcation Line Using Confocal Microscopy and Anterior Segment Optical Coherence Tomography in Keratoconic Patients – Corrected Proof
Purpose: To evaluate and compare the depth of the corneal stromal demarcation line after corneal collagen cross-linking (CXL) using 2 different methods: confocal microscopy and anterior segment optical coherence tomography (AS OCT).Design: Prospective,…
The Pattern and Distribution of Retinal Breaks in Eyes With Rhegmatogenous Retinal Detachment – Corrected Proof
Purpose: To identify which presenting features of rhegmatogenous retinal detachment (RRD) suggest the presence of multiple retinal breaks and to ascertain relevant patterns in retinal break location.Design: Observational single-center case series.Metho…
The Stability of the Monofixation Syndrome – Corrected Proof
Purpose: To determine etiology, characteristics, and stability of the monofixation syndrome (MFS) in a chart review of 63 consecutive patients in a private practice of pediatric ophthalmology.Design: Retrospective, consecutive chart review.Methods: The…
Acanthamoeba, Fungal, and Bacterial Keratitis: A Comparison of Risk Factors and Clinical Features – Corrected Proof
Purpose: To determine risk factors and clinical signs that may differentiate between bacterial, fungal, and acanthamoeba keratitis among patients presenting with presumed infectious keratitis.Design: Hospital-based cross-sectional study.Methods: We exa…
Facilitation of Tear Fluid Secretion by 3% Diquafosol Ophthalmic Solution in Normal Human Eyes – Corrected Proof
Purpose: To evaluate the increase in tear fluid volume induced by 3% diquafosol ophthalmic solution in normal human eyes.Design: Prospective, randomized, double-masked, comparative study.Methods: Twenty healthy adults (17 males and 3 females; mean age,…
Performance of the Visual Field Index in Glaucoma Patients With Moderately Advanced Visual Field Loss – Corrected Proof
Purpose: To explore the relationship between the visual field index (VFI) and the visual field mean deviation (MD) in glaucoma patients with moderately advanced perimetric damage and to identify the magnitude of the boundary effect of VFI that occurred when the VFI estimation strategy changed from pattern deviation probability value to total deviation probability value as the MD crossed −20 dB in longitudinal visual field (VF) series.Design: A retrospective cohort study of longitudinal data analysis.Methods: The MD and VFI values obtained from VF tests conducted on 148 eyes of 148 glaucoma patients having an MD around −20 dB were studied. A total of 1286 VFs with MD values within the range of −16 dB to −24 dB were included. The eyes were divided into 2 groups, with the first having serial MDs all better than or all worse than −20 dB and the second with serial MDs crossing the −20 dB value. Change in MD (ΔMD) was defined as the absolute difference between the MD values of 2 consecutive VFs. Based on the 2 VFI values of the same VFs, the absolute value of change in VFI (ΔVFI) was calculated.Results: The means (± standard deviation) for the ΔVFI were 4.17% (± 3.3%) in the group of eyes with MDs on either side of −20 dB, and were 15.8% (± 8.4%) in the group with MDs crossing −20 dB (P < .0001). For ΔVFI/ΔMD, these values were 6.8%/dB (± 10.5%) when the range of MD falls on either side of −20 dB, and 7.9%/dB (± 6.2%) when the range of MD crosses the −20 dB values (P = .042).Conclusions: The values of the VFI become highly variable in serial VFs of eyes with MDs crossing −20 dB, in comparison to those VFIs associated with MDs on either side of −20 dB. The likelihood for this effect is the change from use of pattern deviation probability value to total deviation probability value in the points included in the calculation of VFI at −20 dB of MD. The development of indices to measure VF rates that are free from this boundary effect in moderately advanced glaucoma is desirable.
Polymorphisms in genetics of Vitamin D metabolism confer susceptibility to ocular Behçet disease in a Chinese Han population – Accepted Manuscript
Abstract: Purpose: To test whether singlenucleotidepolymorphisms(SNPs) of the four Vitamin D family genes(DHCR7, CYP2R1, CYP27B1 and CYP24A1) previously associated with several autoimmune diseases, are associated with ocular Behçet disease, Vogt-Koyan…
Recurrent Orbital Varices Following Surgical Excision With and Without Prior Embolization with n-Butyl Cyanoacrylate – Accepted Manuscript
Abstract: Purpose: To report a series of four recurrent orbital varices following resection, two of which were embolized with cyanoacrylate glue preoperatively.Design: Retrospective case seriesMethods: Charts of all patients seen by a single orbital su…
Dry Eye Disease and Work Productivity Loss in Visual Display Users: The Osaka Study – Accepted Manuscript
Abstract: Purpose: To estimate the impact of dry eye disease (DED) on work performance and productivity in office workers using visual display terminals (VDTs).Design: Cross-sectional study.Methods: Six hundred and seventy-two Japanese young and middle-aged office workers using VDTs completed questionnaire which was designed to measured at-work performance deficits and productivity losses using the Japanese version of the Work Limitations Questionnaire, completed by e-mail. Using the Japanese dry eye diagnostic criteria, respondents were classified into three groups: definite DED, probable DED, and non-DED.Results: Of the 672 office workers, 553 subjects (82.3%) including 366 men and 187 women completed the questionnaire and underwent clinical evaluation. As for the total workplace productivity loss, the non-DED group demonstrated a loss of 3.56%, those with probable DED, a loss of 4.06%, and those with definite DED, a loss of 4.82%, indicating significantly worse performance and productivity (trend test p=0.014). For the four subscales, DED was associated with significantly lower on-the-job time management (trend test p=0.009) and mental performance/interpersonal functioning (trend test p=0.011). After controlling for age, gender, VDT working hours, and diagnosis of DED, time management, physical demands, and mental/interpersonal functioning, showed a significant relationship to DED (each p>0.05). Annual DED productivity losses were estimated to be $6,160 per employee when measured by total production and $ 1,178 per employee calculated by wage.Conclusions: This study indicates that there is a significant impact of DED on the total productivity of Japanese visual display terminal users.
Risk factors for ocular surface squamous neoplasia recurrence following treatment with topical mitomycin C and interferon alpha-2b – Accepted Manuscript
Abstract: Purpose: To determine the rate of recurrence and associated risk factors following the use of mitomycin C (MMC) and/or interferon alpha-2b (IFN) for management of non-invasive ocular surface squamous neoplasia (OSSN).Design: Retrospective non…
Half-Dose Photodynamic Therapy Targeting the Leakage Point on the Fluorescein Angiography in Acute Central Serous Chorioretinopathy: A Pilot Study – Accepted Manuscript
Abstract: Purpose: To evaluate the efficacy of half-dose photodynamic therapy (PDT) targeting only the focal leakage point on fluorescein angiography for acute central serous chorioretinopathy (CSC).Design: Non-randomized, retrospective, comparative, i…
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We thank Dr Coroneo for the comments and interest in our article. We agree that if the posterior capsule is stained with trypan blue, completion of the surgery, although more difficult, can still be performed successfully, and we believe it is importan…
Pterygium: Techniques and Technologies for Surgical Succes
Media Type: Textbook Synopsis: This textbook provides a comprehensive, yet concise, review of the current understanding of pterygia and existing treatment options. It is a clear, well-written account, highlighted with excellent figures that help illu…
Inadvertent Trypan Blue Posterior Capsule Staining during Cataract Surgery
The article by Burkholder and associates is a useful addition to the literature in that it highlights the relatively uncommon complication of inadvertent trypan blue staining of the posterior capsule and adds to the list of risk factors (that includes …
The Effect of Prior Trabeculectomy on Refractive Outcomes of Cataract Surgery
We read with great interest the article titled The Effect of Prior Trabeculectomy on Refractive Outcomes of Cataract Surgery by Zhang and associates. We applaud the authors for highlighting the issue of refractive surprises following cataract surgery i…
Reporting Visual Acuities
The AJO encourages authors to report the visual acuity in the manuscript using the same nomenclature that was used in gathering the data provided they were recorded in one of the methods listed here. This table of equivalent visual acuities is provided…