Author: Am J Ophthalmol

Clinical Manifestations of Patients with Intraocular Inflammation and Positive QuantiFERON–TB Gold In-Tube Test in a Country Non-endemic for Tuberculosis – Accepted Manuscript

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Abstract: Purpose: To evaluate clinical manifestations of patients with uveitis and scleritis of unknown origin and positive QuantiFERON–TB test Gold In-Tube (quantiferon) in a country not endemic for tuberculosis.Design: Multicentre retrospective co…

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A Multicenter, Open-Label, 52-Week Study of 2% Rebamipide (OPC-12759) Ophthalmic Suspension in Patients with Dry Eye – Accepted Manuscript

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Abstract: Purpose: To investigate the efficacy and safety of 2% rebamipide ophthalmic suspension administered 4 times daily for 52 weeks in patients with dry eye.Design: Multicenter (17 sites), open-label single-arm study.Methods: A total of 154 patients with dry eye were enrolled in this study. After a 2-week screening period, patients received 2% rebamipide, instilled as 1 drop in each eye, 4 times daily for 52 weeks. The signs and symptoms measures were assessed at baseline, at weeks 2 and 4, and at every 4 weeks thereafter. The objective signs were fluorescein corneal staining score, lissamine green conjunctival staining score, and (Read more...)

A Method to Estimate the Amount of Neuroretinal Rim Tissue in Glaucoma: Comparison with Current Methods for Measuring Rim Area – Accepted Manuscript

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Abstract: Purpose: To test whether the minimum rim area assessed by spectral domain optical coherence tomography (SD-OCT), based on the shortest distance from Bruch’s Membrane Opening (BMO) to the inner limiting membrane, corresponds more closely to retinal nerve fiber layer (RNFL) thickness and visual field mean deviation (MD) than current rim measures in early glaucoma.Design: Prospective cross-sectional study.Methods: 221 participants with non-endstage glaucoma or high-risk ocular hypertension performed standard automated perimetry, and received SD-OCT and confocal scanning laser ophthalmoscopy (CSLO) scans, on the same day. Rim area measured by CSLO was compared with three SD-OCT rim measures from radial B-scans: (Read more...)

Imaging the Posterior Segment of the Eye using Swept-Source Optical Coherence Tomography in Myopic Glaucoma Eyes: Comparison with Enhanced-Depth Imaging – Accepted Manuscript

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Abstract: Purpose: To compare the detection rates of identifying the posterior border of the sclera and lamina cribrosa and measurement reproducibility of scleral and laminar thicknesses using enhanced depth imaging (EDI) of Heidelberg Spectralis optic…

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Randomized, Prospective, Comparative Trial of EX-PRESS Glaucoma Filtration Device versus Trabeculectomy (XVT Study) – Corrected Proof

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Purpose: To compare the clinical outcomes of the EX-PRESS glaucoma filtration device placed under a partial-thickness scleral flap with trabeculectomy.Design: Randomized, prospective, multicenter trial.Methods: A total of 120 eyes in 120 subjects were analyzed, including 59 eyes treated with EX-PRESS and 61 eyes treated with trabeculectomy. Both the EX-PRESS and the trabeculectomy groups were treated intraoperatively with mitomycin C and followed postoperatively for 2 years. Surgical success was defined as 5 mm Hg ≤ intraocular pressure ≤ 18 mm Hg, with or without medications, without further glaucoma surgery.Results: Mean intraocular pressure was significantly reduced compared with baseline in both groups (P < (Read more...)

Impact of Crystalline Lens Opacification on Effective Phacoemulsification Time in Femtosecond Laser-Assisted Cataract Surgery – Corrected Proof

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Purpose: To compare effective phacoemulsification time in cataract surgery performed by manual phacoemulsification vs femtosecond laser-assisted lens fragmentation.Design: Retrospective, consecutive, nonrandomized, comparative case series.Methods: The setting was the Department of Ophthalmology, Goethe-University, Frankfurt, Germany. The study population included 150 eyes of 86 patients with senile cataract. In the intervention, 88 eyes (group 1) underwent femtosecond laser-assisted surgery (corneal incisions, capsulotomy, lens fragmentation) using the LenSx platform (Alcon) and residual lens work-up with pulsed ultrasound energy (Infiniti Vision System; Alcon). In 62 eyes (group 2), complete cataract removal was performed with phacoemulsification only, using pulsed ultrasound energy with the same device (Read more...)

A multivariate analysis and statistical model for predicting visual acuity and keratometry one year after crosslinking for keratoconus – Accepted Manuscript

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Abstract: Purpose: To investigate putative prognostic factors for predicting visual acuity and keratometry one year following corneal cross-linking (CXL) for treating keratoconus.Design: Prospective cohort study.Methods: This study included all consecutively treated keratoconus patients (102 eyes) in one academic treatment centre, with minimal one-year follow-up following CXL. Primary treatment outcomes were corrected distance visual acuity (logMAR CDVA) and maximum keratometry (Kmax). Univariable analyses were performed to determine correlations between baseline parameters and follow-up measurements. Correlating factors (P≤0.20) were then entered into a multivariable linear regression analysis, and a model for predicting CDVA and Kmax was created.Results: Atopic constitution, positive family history (Read more...)

Optic disc planimetry, corneal hysteresis, central corneal thickness and intraocular pressure as risk factors for glaucoma – Accepted Manuscript

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Abstract: Purpose: To determine whether corneal hysteresis and central corneal thickness are independent risk factors for glaucoma.Design: This was a cross-sectional population based cohort study.Methods: Associations were tested between corneal hysteresis, measured in 1754 population-based subjects from the TwinsUK cohort, and glaucoma-related endophenotypes, including intraocular pressure (IOP), vertical cup to disc ratio, optic disc area and optic disc cup area. Corneal hysteresis, IOP and Central Corneal Thickness (CCT) were measured using the Ocular Response Analyser (ORA-Reichert® Buffalo, NY). Optic disc photographs were analysed using the Stereo DX program. Multivariable linear regression analysis was performed using STATA software.Results: Data was available (Read more...)

Corneal changes in Xeroderma Pigmentosum: a clinicopathological Report – Accepted Manuscript

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Abstract: Purpose: To report the clinicopathological features of corneal involvement in patients with Xeroderma pigmentosum.Design: Retrospective review of corneal histopathology.Methods: Thirteen corneal specimens of 11 patients with Xeroderma pigmentosum who underwent keratoplasty (lamellar/full- thickness) for corneal involvement were studied. Five microns thick sections were made from all the samples and stained using Hematoxylin & Eosin (H & E) and Periodic Acid Schiff (PAS) stains. A light microscopic examination was performed to study the histopathological changes.Results: The corneal findings on clinical examination were haze, scarring, vascularization, stromal edema, pigment clumps on endothelial surface and corneal thinning. The histopathological evaluation revealed changes (Read more...)