In 2012, the American Academy of Ophthalmology joined 16 medical specialty societies in the second wave of the Choosing Wisely campaign, initiated by the American Board of Internal Medicine (ABIM) Foundation. Participating societies each created a list…
Author: Ophthalmology
Contents
This Issue At A Glance
治疗角膜内皮疾病时, 角膜内皮移植手术 (DSEK) 相比传统的全层穿透性角膜移植术 (PK) 昂贵, 然而 Bose 等人 (p. 464) 发现, 从成本效益的角度看, DSEK 应是二者中的首选. 该研究举例, 假设给予固定
Author reply
We appreciate the comments of Dr. Mamalis. We were unaware of the disagreements that the American Society of Cataract and Refractive Surgery (ASCRS) TASS force had with the Food and Drug Administration’s.
Bacterial Keratitis in Shanghai
The recent report by Lichtinger et al describing the clinical characteristics of bacterial keratitis isolates over a 11-year period within a Toronto institution raised our interest. Although we found several previous studies about the distribution, cur…
Author reply
We thank Hong et al for their interest in our paper “Shifting Trends in Bacterial Keratitis in Toronto, an 11 Year Review.” In our paper, we reviewed the microbiology records of 1701 consecutive corneal scrapings; our main findings were a significa…
Author reply
We thank Hong et al for their comments regarding our manuscript and would like to address several important issues that they raise. The focus of our paper was specifically to study keratoplasty among patients with corneal endothelial disease (CED). Exp…
Enzymatic Detergents and Toxic Anterior Segment Syndrome
We read with interest the article by Leder et al entitled “An Investigation of Enzymatic Detergents as a Potential Cause of Toxic Anterior Segment Syndrome.” The authors investigated whether enzymatic detergents used in the cleaning of ophthalmic i…
Infection Following Photorefractive Keratectomy
Photorefractive keratectomy (PRK) is the most commonly performed refractive procedure in the US military and is regaining popularity in the civilian world as a safe alternative to LASIK. Pain after PRK is often significant, but can be mediated with the…
Keratoplasty for Corneal Endothelial Disease
We read the article by Shtein et al on the rates of keratoplasty for corneal endothelial disease (CED) in a large cohort in the United States with interest. The researchers found that patients with CED had increased odds of undergoing keratoplasty in 2…
n-3 Fatty Acids and Retinal Function
Ageing is associated with progressive loss of retinal function characterized by altered rod and cone electroretinographic responses to light stimulation. n-3 long-chain polyunsaturated fatty acids (LCPs), especially eicosapentaenoic acid and docosahexa…
United States Food and Drug Administration TASS Program
I read with interest the article by Eydelman et al announcing the Food and Drug Administration’s (FDAs) proactive toxic anterior segment syndrome program, as well the accompanying editorial by Gottsch and Schein. The article and the editorial describe …
Author reply
We thank Boto-de-los-Bueis et al for their interest in our article and for sharing a complementary case featuring salt and pepper alterations of the corneal endothelium. This novel phenotype has recently been described in 2 asymptomatic men with transp…
Quantitative Evaluation of Drusen on Photographs
Visualizing and tracking drusen is important in managing age-related macular degeneration. Color fundus photography (CFP) is common in clinical practice, but quantitative evaluation of drusen in CFPs is difficult because of the varying background of th…
Editorial Board
Classification of Secondary Corneal Amyloidosis and Involvement of Lactoferrin – Corrected Proof
Purpose:
To classify secondary corneal amyloidosis (SCA) by its clinical appearance, to analyze the demographics of the patients, and to determine the involvement of lactoferrin.
Design:
Retrospective, observational, noncomparative, multicenter stu…
Streptococcus Endophthalmitis Outbreak after Intravitreal Injection of Bevacizumab: One-Year Outcomes and Investigative Results – Corrected Proof
Purpose:
To report the 1-year clinical outcomes of an outbreak of Streptococcus endophthalmitis after intravitreal injection of bevacizumab, including visual acuity outcomes, microbiological testing, and compound pharmacy investigations by the Food a…
Glaucoma Severity and Medication Adherence in a County Hospital Population – Corrected Proof
Objective:
To assess the association between disease severity and adherence with glaucoma medications in a county hospital population.
Design:
Cross-sectional study.
Participants:
A total of 126 patients diagnosed with glaucoma receiving intraocular pressure (IOP)–lowering medication were recruited from the San Francisco General Hospital Ophthalmology Clinic.
Methods:
Subjects completed an oral questionnaire to assess demographic information, knowledge of glaucoma, and perceptions of glaucoma medication adherence. Glaucoma disease severity was classified according to the American Academy of Ophthalmology’s Preferred Practice Pattern guidelines. Medication adherence was measured for each patient by obtaining pharmacy refill data and calculating medication possession ratio (MPR), that is, the ratio of total days’ supply of medication during a 365-day period. Adherence was measured retrospectively over the 18-month period before study entry. Subjects with an MPR >80% were considered adherent.
Main Outcome Measure:
Medication adherence.
Results:
Subjects with mild or moderate glaucoma were more likely to be nonadherent to their prescribed glaucoma medications than those with severe disease (adjusted odds ratio [OR], 1.54; 95% confidence interval [CI], 1.03–2.31; P = 0.04). Age, gender, race, education level, years of glaucoma, number of medications, and glaucoma diagnosis were not found to be statistically significantly associated with adherence.
Conclusion:
Patients with severe glaucoma were more likely to adhere to their topical IOP-lowering medication regimen than those with milder glaucomatous disease.
Financial Disclosure(s):
Proprietary or commercial disclosure may be found after the references.
Ranibizumab Treatment Outcomes in Phakic versus Pseudophakic Eyes: An Individual Patient Data Analysis of 2 Phase 3 Trials – Corrected Proof
Objective:
To compare visual outcomes in phakic and pseudophakic eyes treated with monthly intravitreal ranibizumab for exudative age-related macular degeneration (AMD).
Design:
Meta-analysis of individual patient data from 2 phase 3 clinical trial…
A Phenotype–Genotype Correlation Study of X-Linked Retinoschisis – Corrected Proof
Purpose:
To compare the clinical phenotype and detailed electroretinographic parameters in X-linked retinoschisis (XLRS).
Design:
Retrospective, comparative study.
Participants:
Fifty-seven patients (aged 1–67 years) with molecularly confirmed …