Purpose: Evaluate the usefulness of toric intraocular lens (IOL) implantation during cataract surgery in patients after penetrating keratoplasty (PKP).Design: Retrospective case review.Participants: A total of 21 eyes of 16 patients with prior PKP and …
Author: Ophthalmology
Differentiating Mild Papilledema and Buried Optic Nerve Head Drusen Using Spectral Domain Optical Coherence Tomography – Corrected Proof
Purpose: To evaluate the clinical utility of spectral domain optical coherence tomography (SD-OCT) in differentiating mild papilledema from buried optic nerve head drusen (ONHD).Design: Comparative case series.Participants: Sixteen eyes of 9 patients w…
Incidence, Types, and Lifetime Risk of Adult-Onset Strabismus – Corrected Proof
Objective: To describe the incidence and types of adult-onset strabismus in a geographically defined population.Design: Retrospectively reviewed population-based cohort.Participants: All adult (≥19 years of age) residents of Olmsted County, Minnesota, diagnosed with new-onset adult strabismus from January 1, 1985, through December 31, 2004.Methods: The medical records of all potential cases identified by the resources of the Rochester Epidemiology Project were reviewed.Main Outcome Measures: Incidence rates for adult-onset strabismus and its types.Results: Seven hundred fifty-three cases of new-onset adult strabismus were identified during the 20-year period, yielding an annual age- and gender-adjusted incidence rate of 54.1 cases (95% confidence interval, 50.2–58.0) per (Read more...)
Diagnosing Ocular Surface Squamous Neoplasia in East Africa: Case-Control Study of Clinical and In Vivo Confocal Microscopy Assessment – Corrected Proof
Objective: To examine the reliability of clinical examination and in vivo confocal microscopy (IVCM) in distinguishing ocular surface squamous neoplasia (OSSN) from benign conjunctival lesions.Design: Case-control study.Participants: Sixty individuals…
RADIANCE: A Randomized Controlled Study of Ranibizumab in Patients with Choroidal Neovascularization Secondary to Pathologic Myopia – Corrected Proof
Objective: To compare the efficacy and safety of ranibizumab 0.5 mg, guided by visual acuity (VA) stabilization or disease activity criteria, versus verteporfin photodynamic therapy (vPDT) in patients with visual impairment due to myopic choroidal neovascularization (CNV).Design: Phase III, 12-month, randomized, double-masked, multicenter, active-controlled study.Participants: Patients (N = 277) with visual impairment due to myopic CNV.Methods: Patients were randomized to receive ranibizumab on day 1, month 1, and thereafter as needed guided by VA stabilization criteria (group I, n = 106); ranibizumab on day 1 and thereafter as needed guided by disease activity criteria (group II, n = 116); or vPDT on day (Read more...)
Author Reply – Corrected Proof
Dr Fellman’s thoughtful comments allow for an opportunity to provide clarification with regard to the message conveyed in the editorial, “Things Go Better With Cataract Surgery.” First and foremost, I agree with Dr Fellman that blebless surgery is …
Prospective Masked Comparison of Intraoperative Floppy Iris Syndrome Severity with Tamsulosin versus Alfuzosin – Corrected Proof
Objective: To determine whether severe intraoperative floppy iris syndrome (IFIS) is more or equally likely with tamsulosin or alfuzosin.Design: Prospective, masked, multicenter, cross-sectional study.Participants and Controls: Consecutive patients tak…
Risk of Scar in the Comparison of Age-related Macular Degeneration Treatments Trials – Corrected Proof
Objective: To describe risk factors for scar in eyes treated with ranibizumab or bevacizumab for neovascular age-related macular degeneration (AMD).Design: Prospective cohort study within a randomized clinical trial.Participants: Patients with no scar on color fundus photography (CFP) or fluorescein angiography (FA) at enrollment in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT).Methods: Eyes were assigned to ranibizumab or bevacizumab treatment and to 1 of 3 dosing regimens for 2 years. Masked readers assessed CFP and FA. Baseline demographic characteristics, visual acuity, morphologic features on photography and optical coherence tomography (OCT), and genotypes associated with AMD risk were evaluated as (Read more...)
The Ability of Healthy Volunteers to Simulate a Neurologic Field Defect on Automated Perimetry – Corrected Proof
Objective: To determine if volunteers can simulate and reproduce 3 types of neurologic field defects: hemianopia, quadrantanopia, and central scotoma.Design: Cross-sectional study.Participants: Thirty healthy volunteers new to perimetry (including auto…
Vitrectomy with Internal Limiting Membrane Peeling versus No Peeling for Idiopathic Full-Thickness Macular Hole – Corrected Proof
Objective: To determine whether internal limiting membrane (ILM) peeling improves anatomic and functional outcomes of full-thickness macular hole (FTMH) surgery when compared with the no-peeling technique.Design: Systematic review and individual participant data (IPD) meta-analysis undertaken under the auspices of the Cochrane Eyes and Vision Group. Only randomized controlled trials (RCTs) were included.Participants and Controls: Patients with idiopathic stage 2, 3, and 4 FTMH undergoing vitrectomy with or without ILM peeling.Intervention: Macular hole surgery, including vitrectomy and gas endotamponade with or without ILM peeling.Main Outcome Measures: Primary outcome was best-corrected distance visual acuity (BCdVA) at 6 months postoperatively. Secondary outcomes were (Read more...)
The Effect of Colored Overlays on Reading Performance in Infantile Nystagmus – Corrected Proof
Infantile nystagmus (IN) is an involuntary oscillations of the eyes with onset within 6 months from birth. It can result in vision loss owing to constant retinal motion and lead to significant psychosocial problems. Recent studies have described readin…
The Spectrum of Ocular Alterations in Patients with β-Thalassemia Syndromes Suggests a Pathology Similar to Pseudoxanthoma Elasticum – Corrected Proof
Purpose: To determine the prevalence and spectrum of ocular fundus abnormalities in patients with β-thalassemia and to investigate risk factors for their development.Design: Cross-sectional, observational study.Participants: A total of 255 patients with β-thalassemia major (TM) and β-thalassemia intermedia (TI) were consecutively recruited and investigated.Methods: Patients underwent best correct visual acuity, indirect ophthalmoscopy, and fundus photography, including fundus autofluorescence (FAF) and near-infrared reflectance imaging using a confocal scanning laser ophthalmoscope (cSLO). Hematologic parameters were determined, including mean ferritin levels, aspartate amino transferase, alanine amino transferase, calcium, pre-transfusion hemoglobin, history of splenectomy, and liver iron concentration. Factors associated with the ocular phenotype (Read more...)
Associations between Health-Related Quality of Life and the Decision to Perform Surgery for Childhood Intermittent Exotropia – Corrected Proof
Objective: To assess associations between health-related quality of life (HRQOL) and the decision to perform strabismus surgery for children with intermittent exotropia.Design: Retrospective chart review.Participants: Children with intermittent exotropia.Methods: Included subjects, identified in a clinical practice, had assessment of HRQOL using the intermittent exotropia questionnaire (IXTQ), comprising child, proxy, and parent components (parent domains: function, psychosocial, and surgery). The IXTQ scores were evaluated for association with surgery, along with standard clinical measures: prism and alternate cover test (PACT), stereoacuity, and control score (mean of the 3 most recent scores). Included data were from preoperative examination (surgical cohort) or from most (Read more...)
Defining the Limits of Normal Conjunctival Fornix Anatomy in a Healthy South Asian Population – Corrected Proof
Purpose: Quantifying the extent of conjunctival fibrosis for documentation of progression in conjunctival scarring disease is a clinical challenge. Measurement of forniceal foreshortening facilitates monitoring of these disorders. This study aims (1) to define the limits of the normal human conjunctival fornices and how these alter with age and (2) to provide normative data for upper and lower fornix depths (FDs) and fornix intercanthal distance (FICD) within a healthy South Asian, racially distinct population.Design: Epidemiologic, cross-sectional study.Participants: A total of 240 subjects with national origins from South Asia, with no known ocular history and normal adnexal and conjunctival examination, aged (Read more...)
Lack of a Visible Outcome Marker Fuels the Perfect Storm of Dr Singh’s Editorial – Corrected Proof
Dr Singh’s recent editorial entitled “Things Go Better with Cataract Surgery” points out that glaucoma care is unique in that there are inherent difficulties of measurement endpoints, inaccuracies of psychophysical testing, and confounding study va…
Acetazolamide in Retinoschisis: A Prospective Study – Corrected Proof
X-linked retinoschisis (XLRS) is the leading cause of hereditary juvenile macular degeneration in males with an estimated prevalence ranging from 1 in 15 000 to 1 in 30 000. It accounts for approximately 5% of all childhood-onset inherited retinal …
Driving Habits in Older Patients with Central Vision Loss – Corrected Proof
Objective: To determine if central visual loss is associated with driving cessation, driving restriction, or other-driver preference.Design: Cross-sectional study.Participants: Sixty-four subjects with bilateral visual loss (<20/32 in better eye) or severe unilateral visual loss (<20/200) from age-related macular degeneration (AMD) and 58 normally sighted controls between 60 and 80 years of age.Methods: Participants self-reported driving habits. Other-driver preference was defined as preferring that another drive when there is more than 1 driver in the car. Subjects reporting 2 or more driving limitations were considered to have restricted their driving.Main Outcome Measures: Self-reported driving cessation, other-driver preference, and driving restriction.Results: Age-related (Read more...)
Appearance of Regressing Drusen on Adaptive Optics in Age-Related Macular Degeneration – Corrected Proof
In age-related macular degeneration, material between the basal lamina of the retinal pigment epithelium (RPE) and the inner collagenous layer of Bruch’s membrane are generally referred to as drusen. Although drusen “maturation” is characterized by…
Genetic Susceptibility, Dietary Antioxidants, and Long-term Incidence of Age-related Macular Degeneration in Two Populations – Corrected Proof
Objective: To examine effect modification between genetic susceptibility to age-related macular degeneration (AMD) and dietary antioxidant or fish consumption on AMD risk.Design: Pooled data analysis of population-based cohorts.Participants: Participants from the Blue Mountains Eye Study (BMES) and Rotterdam Study (RS).Methods: Dietary intakes of antioxidants (lutein/zeaxanthin [LZ], β-carotene, and vitamin C), long-chain omega-3 polyunsaturated fatty acids, and zinc were estimated from food frequency questionnaires. The AMD genetic risk was classified according to the number of risk alleles of CFH (rs1061170) or ARMS2 (rs10490924) as low (no or 1 risk allele) or high (≥2 risk alleles). Interactions between dietary intake and genetic (Read more...)
Comparison of Outcomes from a Phase 3 Study of Age-Related Macular Degeneration with a Matched, Observational Cohort – Corrected Proof
Objective: To compare outcomes of intravitreal therapy from an observational study cohort with those of participants receiving treatment in the Minimally Classic/Occult Trial of the Anti-VEGF Antibody Ranibizumab (MARINA) for the treatment of neovascul…