Author: Ophthalmology

This Issue At A Glance

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Young et al (p. 2390) compared the long-term outcome of limbal conjunctival autograft (LCAU) with that of intraoperative applications of mitomycin C (MMC) in minimizing pterygium recurrence. They also evaluated the effects of MMC on corneal endothelia…

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A Simple Vista en Este Número

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Young y otros (p. 2390), compararon el resultado a largo plazo del autoinjerto limbal conjuntival (LCAU) con el de la aplicación de mitomicina C (MMC) para minimizar la recurrencia del pterigio. Evaluaron también los efectos de la MMC en la densidad …

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Evidence-Based Ophthalmology

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It is easy to assume that colleagues are familiar with the structure and function of the international Cochrane Collaboration (List of contributors to CEVG available at http://aaojournal.org), but often this is off the mark or their understanding is misinformed. The Collaboration consists of >30 000 persons around the world who are committed to responding to Archie Cochrane’s challenge to the medical world in 1979:It is surely a great criticism of our profession that we have not organized a critical summary, by specialty or subspecialty, adapted periodically, of all relevant randomized controlled (Read more...)

Author reply

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We appreciate the opportunity to discuss the recent report on innovative draping methods to minimize elevated oxygen concentrations in ophthalmic surgical fields. We agree that using a standard nasal cannula does not absolutely eliminate the risk of …

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Author reply

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We appreciate Suelves, Gregori, and Diaz-Llopis’ interest in our recent article “A National Survey of Practice Patterns: Temporal Artery Biopsy.” In this study, we surveyed neuro-ophthalmologists, oculoplastic surgeons, and rheumatologists regarding temporal artery biopsy practices in the assessment of patients suspected to have giant cell arteritis (GCA). Specifically, we questioned practitioners as to whether they favored unilateral or bilateral temporal artery biopsy and their thoughts regarding the effect of prior corticosteroid therapy on biopsy findings. In short, responses varied greatly within and between specialists. Of slightly >1000 respondents, 37% recommended (Read more...)

期刊一览

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Young (p. 2390) 等人对角结膜缘自体结膜移植术(LCAU)及术中使用丝裂霉素C对减少翼状胬肉复发的长期疗效进行了比较。他们也评估了丝裂霉素C对角膜内皮细胞密度(ECD)的影响。在随机、对照试验

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Predicting Progression of Glaucoma from Rates of Frequency Doubling Technology Perimetry Change – Corrected Proof

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Purpose: To evaluate the ability of longitudinal frequency doubling technology (FDT) to predict the development of glaucomatous visual field loss on standard automated perimetry (SAP) in glaucoma suspects.Design: Prospective, observational cohort study.Participants: The study included 587 eyes of 367 patients with suspected glaucoma at baseline selected from the Diagnostic Innovations in Glaucoma Study (DIGS) and the African Descent and Glaucoma Evaluation Study (ADAGES). These eyes had an average of 6.7±1.9 FDT tests during a mean follow-up time of 73.1±28.0 months.Methods: Glaucoma suspects had intraocular pressure (IOP) >21 mmHg or an optic disc appearance suspicious of glaucoma. All patients had normal (Read more...)

Lifitegrast Ophthalmic Solution 5.0% for Treatment of Dry Eye Disease: Results of the OPUS-1 Phase 3 Study – Corrected Proof

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Purpose: To assess the efficacy and safety of lifitegrast ophthalmic solution 5.0% compared with placebo in subjects with dry eye disease.Design: Prospective, randomized, double-masked, placebo-controlled, parallel arm, multicenter clinical trial.Participants: A total of 588 adult subjects with dry eye disease.Methods: Eligible subjects were randomized 1:1 to receive topically administered lifitegrast (5.0%) or placebo (vehicle) twice daily for 84 days after a 14-day open-label placebo run-in period. After enrollment (day 0), subjects were evaluated at days 14, 42, and 84. Key objective (fluorescein and lissamine staining scores [Ora scales]) and subjective (Ocular Surface Disease Index [OSDI], 7-item visual analog scale, and ocular (Read more...)

Discriminant Value of Custom Ocular Response Analyzer Waveform Derivatives in Keratoconus – Corrected Proof

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Purpose: To evaluate the performance of corneal hysteresis (CH), corneal resistance factor, and 16 investigator-derived Ocular Response Analyzer (ORA) variables in distinguishing keratoconus (KC) from the nondiseased state.Design: Retrospective case series.Participants: Fifty-four eyes of 27 unaffected patients and 49 eyes of 25 KC patients from the Instituto de Olhos, Rio de Janeiro, Brazil.Methods: Sixteen candidate variables were derived from exported ORA signals to characterize putative indicators of biomechanical behavior. Area under the receiver operating characteristic curve (AUC) and the Z statistic were used to compare diagnostic performance.Main Outcome Measures: Discriminant value of standard and derived ORA variables as measured by (Read more...)