Advanced age-related macular degeneration and inherited macular diseases remain largely untreatable. Clinical trials using stem cell transplantation have recently commenced and mark a further step in introducing cellular therapy for these diseases. Ear…
Author: Ophthalmology
Retinal Layer Segmentation in Patients with Multiple Sclerosis Using Spectral Domain Optical Coherence Tomography – Corrected Proof
Purpose: To evaluate the thickness of the 10 retinal layers in the paramacular area of patients with multiple sclerosis (MS) compared with healthy subjects using the new segmentation technology of spectral domain optical coherence tomography (OCT). To examine which layer has better sensitivity for detecting neurodegeneration in patients with MS.Design: Observational, cross-sectional study.Participants: Patients with MS (n = 204) and age-matched healthy subjects (n = 138).Methods: The Spectralis OCT system (Heidelberg Engineering, Inc., Heidelberg, Germany) was used to obtain automated segmentation of all retinal layers in a parafoveal scan in 1 randomly selected eye of each participant, using the new segmentation application (Read more...)
Sulcus Fixation of a 3-Piece Diffractive Multifocal Intraocular Lens with and without Optic Capture in the Anterior Capsulorhexis – Corrected Proof
Complications during cataract surgery, for example, posterior capsule tear, may prevent intraocular lens (IOL) fixation in the capsular bag. However, the IOL may still be placed in the ciliary sulcus if there was sufficient anterior capsular support.
Does Intra-arterial Chemotherapy Improve Survival for Lacrimal Gland Adenoid Cystic Carcinoma? – Corrected Proof
Tse et al summarize the long-term outcomes in 19 patients with adenoid cystic carcinoma of lacrimal gland who underwent treatment on an investigational protocol that entailed receiving intra-arterial chemotherapy (IAC) followed by orbital exenteration…
A Multivitamin Supplement and Cataract and Age-Related Macular Degeneration in a Randomized Trial of Male Physicians – Corrected Proof
Purpose: To test whether long-term multivitamin supplementation affects the incidence of cataract or age-related macular degeneration (AMD) in a large cohort of men.Design: Randomized, double-blind, placebo-controlled trial.Participants: A total of 14
Resident and Fellow Participation in Strabismus Surgery: Effect of Level of Training and Number of Assistants on Operative Time and Cost – Corrected Proof
Objective: To investigate the effect of the level of training and number of assistants on operative time for uncomplicated, 2-muscle, horizontal strabismus surgery at an academic institution.Design: Comparative case series.Participants: A total of 993 …
Improvement From No Light Perception after Orbital Decompression for Optic Neuropathy – Corrected Proof
Compressive optic neuropathy (CON) is among the most severe complications of thyroid eye disease (TED). Orbital decompression has proved to be an effective treatment modality to prevent blindness in TED. Indications for orbital decompression in thyroid…
Author reply – Corrected Proof
Esmaeli’s request for clarification of issues regarding our study involves 11 points related to both the intra-arterial cytoreductive chemotherapy (IACC) protocol design and our analysis. First, the introductory quotation attributed to us was not a sta…
Low-Fluence Photodynamic Therapy versus Ranibizumab for Chronic Central Serous Chorioretinopathy: One-Year Results of a Randomized Trial – Corrected Proof
Purpose: To compare the efficacy and safety between low-fluence photodynamic therapy (PDT) and the intravitreal ranibizumab in the treatment of chronic central serous chorioretinopathy (CSC).Design: Prospective, randomized, single-center, parallel-arm, controlled trial.Participants: Thirty-four eyes of 32 patients with chronic CSC with >6 months’ duration of symptoms or recurrent CSC were randomly placed into the low-fluence PDT group (n = 18) or the ranibizumab group (n = 16).Intervention: The patients underwent a single session of low-fluence PDT or 3 consecutive monthly injections of ranibizumab. Rescue treatment was available from month 3 if the subretinal fluid (SRF) persisted or recurred after primary treatment; low-fluence PDT (Read more...)
Is There Risk of Stroke with Aflibercept? – Corrected Proof
The VIEW 1 and 2 studies have shown that aflibercept is an effective treatment for neovascular age-related macular degeneration, but does it come at a cost of an increased risk of stroke?
Author reply – Corrected Proof
Beaumont et al and Ueta raise concerns about the systemic safety of aflibercept for intravitreal injection, particularly regarding cerebrovascular risk and stroke, based on their analysis of safety data from the VIEW studies comparing aflibercept to r…
Thoughts on Skills and Knowledge – Corrected Proof
Related to Dr Bartley’s editorial on ignorance, epistemology, and the circle of least confusion, I wish to share how the concept of useful ignorance can be applied to the 4 stages of skill acquisition. As taught to me by my father, the stages are unco…
Safety in Aflibercept versus Ranibizumab – Corrected Proof
Aflibercept seems to have equivalent effectiveness to ranibizumab, even though it requires less frequent injections. Although the effectiveness of vascular endothelial growth factor (VEGF) inhibitors for age-related macular degeneration (AMD) is unques…
Macular Morphology in Patients with Optic Nerve Head Drusen and Optic Disc Edema – Corrected Proof
Purpose: In this study we investigated macular morphology, including individual retinal layers, in patients with optic nerve head drusen (ONHD) and optic disc edema (ODE) compared with healthy participants, using high-resolution spectral domain optical coherence tomography (OCT).Design: Prospective, cross-sectional, observational study.Participants: A total of 67 patients with ONHD, 36 patients with ODE, and 57 healthy participants.Methods: High-resolution spectral domain OCT (Copernicus [OPTOPOL Technology S.A., Zawiercie, Poland] 3-μm resolution, 7×7×2-mm volumetric scans) was used to image macula morphology. Average retinal nerve fiber layer (RNFL) thickness was measured using a semiautomated method with manual correction of the internal limiting membrane, RNFL, and (Read more...)
Descemet’s Membrane Endothelial Keratoplasty: Clinical Results of Single Versus Triple Procedures (Combined with Cataract Surgery) – Corrected Proof
Purpose: To compare the outcomes of triple Descemet’s membrane endothelial keratoplasty (DMEK) versus DMEK alone in pseudophakic eyes.Design: Retrospective, comparative, interventional case series.Participants: Patients with Fuchs’ endothelial dystrophy, secondary corneal edema, and prior failed endothelial keratoplasty with or without prior cataract extraction.Methods: Outcomes of 492 DMEK procedures performed between April 2010 and August 2012 were reviewed; 292 pseudophakic eyes underwent DMEK (group 1) and 200 eyes had concurrent cataract surgery with DMEK (group 2).Main Outcome Measures: Corrected distance visual acuity, endothelial cell loss, immediate and early postoperative complications.Results: The mean age at the time of surgery was 70 years (range, (Read more...)
Peripapillary Choroidal Cavitation – Corrected Proof
We read with interest the article of Yeh et al concerning the retrospective evaluation of patients with peripapillary choroidal cavitation (PCC) by optical coherence tomography (OCT; Stratus 3000). The authors pointed out that 93.5% of cases of PCC we…
Randomized Trial of a Home Monitoring System for Early Detection of Choroidal Neovascularization Home Monitoring of the Eye (HOME) Study – Corrected Proof
Objective: To determine whether home monitoring with the ForeseeHome device (Notal Vision Ltd, Tel Aviv, Israel), using macular visual field testing with hyperacuity techniques and telemonitoring, results in earlier detection of age-related macular deg…
Natural History and Retinal Structure in Patients with Usher Syndrome Type 1 Owing to MYO7A Mutation – Corrected Proof
Purpose: To evaluate the phenotypic variability and natural history of ocular disease in a cohort of 28 individuals with MYO7A-related disease. Mutations in the MYO7A gene are the most common cause of Usher syndrome type 1, characterized by profound congenital deafness, vestibular arreflexia, and progressive retinal degeneration.Design: Retrospective case series.Participants: Twenty-eight patients from 26 families (age range, 3–65 years; median, 32) with 2 likely disease-causing variants in MYO7A.Methods: Clinical investigations included fundus photography, optical coherence tomography, fundus autofluorescence (FAF) imaging, and audiologic and vestibular assessments. Longitudinal visual acuity and FAF data (over a 3-year period) were available for 20 and (Read more...)
High-Power Handheld Blue Laser-Induced Maculopathy: The Results of the King Khaled Eye Specialist Hospital Collaborative Retina Study Group – Corrected Proof
Purpose: To report various types of maculopathy caused by momentary exposure to a high-power handheld blue laser.Design: Consecutive case series.Participants: Fourteen eyes of 14 patients.Methods: Patients with a history of eye exposure to a blue laser…
Pretreatment Anterior Segment Imaging During Acute Primary Angle Closure: Insights into Angle Closure Mechanisms in the Acute Phase – Corrected Proof
Objective: To describe anterior segment optical coherence tomography (ASOCT) parameters during acute primary angle closure (APAC) before therapeutic interventions and comparative analyses of biometric parameters of APAC eyes with fellow eyes.Design: Prospective, comparative case series.Participants: Thirty-one consecutive patients with APAC.Methods: All patients underwent ASOCT imaging of both eyes during the attack, before therapeutic interventions were administered. Custom software was used to measure anterior chamber depth (ACD), anterior chamber area (ACA), anterior chamber volume (ACV), iris curvature (I-Curv), iris area (I-Area), lens vault (LV), and angle opening distance (AOD750), trabecular iris space area (TISA750), and iris thickness (IT750) at 750 μm (Read more...)