Objective: To determine long-term outcomes of patients with ranibizumab-treated retinal vein occlusion (RVO).Design: Prospective follow-up of a subset of patients from 2 phase 3 trials.Participants: Thirty-four patients with branch RVO (BRVO) and 32 wi…
Category: Peer-reviewed
Eyelid Sebaceous Carcinoma: Clinicopathologic and Multiparametric Immunohistochemical Analysis That Includes Adipophilin – Corrected Proof
Purpose: To evaluate the fine cytopathologic features and immunohistochemistry of eyelid sebaceous carcinoma.Design: Retrospective clinicopathologic study.Methods: Clinical records and microscopic glass slides of 12 patients diagnosed with sebaceous ca…
Randomized Controlled Trial of Intravitreal Ranibizumab Versus Standard Grid Laser for Macular Edema Following Branch Retinal Vein Occlusion – Corrected Proof
Purpose: To assess the efficacy of intravitreal 0.5 mg ranibizumab for the treatment of center-involving macular edema secondary to branch retinal vein occlusion (BRVO) over 1 year compared with standard-of-care grid laser.Design: A prospective random…
Three-Year Incidence and Factors Associated With Posterior Capsule Opacification After Cataract Surgery: The Australian Prospective Cataract Surgery and Age-related Macular Degeneration Study – Corrected Proof
Purpose: To assess 3-year incidence and associated factors of posterior capsule opacification (PCO) after phacoemulsification surgery.Design: Cohort study.Methods: A total of 1934 consecutive patients aged ≥64 years undergoing phacoemulsification sur…
Visual and Refractive Outcomes of Femtosecond Lenticule Extraction and Small-Incision Lenticule Extraction for Myopia – Corrected Proof
Purpose: To compare the visual and refractive outcomes of femtosecond lenticule extraction (FLEx) and small-incision lenticule extraction (SMILE) in eyes with myopia.Design: Prospective, randomized, masked clinical trial with intraindividual comparison…
Evaluation of Levator Function for Efficacy of Minimally Invasive and Standard Techniques for Involutional Ptosis – Corrected Proof
Purpose: To evaluate clinical and anatomic outcomes of surgery for involutional ptosis using standard-length or small incisions in relation to preoperative levator function.Design: Retrospective study.Methods: Sixty-three patients diagnosed with involutional ptosis who underwent surgical correction using a small or standard-length incision between November 2010 and December 2011 were reviewed; a single surgeon performed surgery using a small incision (8 to 10 mm) in 22 patients and a standard-length incision (20 to 22 mm) in 34 patients. All patients underwent standard preoperative ptosis evaluation with margin-to-reflex distance 1 and 2 measurements and levator function assessment. Patients were divided into 2 groups according to levator function (moderate: 5 to 10 mm; and good: >10 mm). Surgical success was evaluated based on the British Oculoplastic Surgery Society criteria.Results: Of 83 upper eyelids of 63 patients, surgery was performed using a small incision in 40 and a standard incision in 43. In patients with good levator function, surgical success was achieved with a small incision in 18 eyelids (94.7%) and a standard incision in 20 eyelids (95.2%; P = .91). In patients with moderate levator function, surgical success was achieved with a small incision in 14 eyelids (66.7%) and with a standard incision in 18 eyelids (81.8%; P = .04).Conclusions: These findings indicate a similar surgical success rate in patients with good levator function, regardless of incision length. The surgical success rate in patients with moderate levator function was lower when using a small incision, perhaps because of decreased visualization and anatomic access.
Epidemiology and Disease Burden of Pathologic Myopia and Myopic Choroidal Neovascularization: An Evidence-Based Systematic Review – Corrected Proof
Purpose: To summarize the epidemiology of pathologic myopia and myopic choroidal neovascularization (CNV) and their impact on vision.Design: Systematic literature review of all English-language studies evaluating the epidemiology and visual burden of p…
Intraocular Lens Power Calculation by Ray-Tracing after Myopic Excimer Laser Surgery – Corrected Proof
Purpose: To investigate the refractive outcomes of intraocular lens (IOL) power calculation by ray-tracing after myopic excimer laser surgery.Design: Prospective, interventional case series.Methods: setting: Multicenter study. participants: Twenty-one …
KRT12 Mutations and In Vivo Confocal Microscopy in Two Japanese Families With Meesmann Corneal Dystrophy – Corrected Proof
Purpose: To identify genetic mutations and study the corneal epithelium in Japanese patients with Meesmann corneal dystrophy.Design: Laboratory investigation and prospective observational case series.Methods: Slit-lamp biomicroscopy with fluorescein vi…
Metamorphopsia and Optical Coherence Tomography Findings After Rhegmatogenous Retinal Detachment Surgery – Corrected Proof
Purpose: To investigate the relationship between metamorphopsia and macular morphologic changes after successful repair of rhegmatogenous retinal detachment (RD).Design: Prospective, interventional, consecutive study.Methods: The study included 129 eyes of 129 patients who had undergone successful retinal reattachment surgery. The severity of metamorphopsia was recorded using M-CHARTS and foveal microstructure was assessed with spectral-domain optical coherence tomography (OCT) at 6-12 months postoperatively.Results: The mean metamorphopsia score was 0.30 ± 0.46, and 50 of 129 patients (39%) had metamorphopsia. Metamorphopsia was more severe in eyes with macula-off rhegmatogenous RD than those with macula-on (P < .001). Eighteen of 50 eyes with metamorphopsia exhibited abnormal structures in the macular region (epiretinal membrane, disruption of the photoreceptor inner and outer segment junction, cystoid macular edema, macular hole, or subretinal fluid), whereas the other 32 eyes showed no morphologic changes with OCT. In these 32 eyes, the horizontal metamorphopsia score (0.86 ± 0.50) was significantly higher than the vertical metamorphopsia score (0.62 ± 0.39, P < .05). Nine of 69 eyes with preoperative macula-on rhegmatogenous RD developed postoperative metamorphopsia. Of the 9 eyes, 6 showed abnormal macular structures and the other 3 had normal-appearing OCT. The macula briefly detached during vitrectomy in these 3 cases.Conclusions: In eyes that remained macula-on throughout surgery and had normal-appearing OCT, metamorphopsia did not develop. In some cases, the reason for metamorphopsia was anatomically obvious. In other cases that were preoperative and intraoperative macula-off, postoperative retinal vertical displacement could cause predominantly horizontal metamorphopsia.
Using human induced pluripotent stem cells to treat retinal disease
Publication date: Available online 6 October 2013 Source:Progress in Retinal and Eye Research Author(s): S. Borooah , M.J. Phillips , B. Bilican , A.F. Wright , I. Wilmut , S. Chandran , D. Gamm , B. Dhillon The eye is an ideal…
Focal Choroidal Excavation Complicated by Choroidal Neovascularization – Corrected Proof
Purpose: To evaluate the clinical findings of focal choroidal excavation (FCE) complicated by choroidal neovascularization (CNV).Design: Retrospective, observational case series.Participants: Twelve patients (15 eyes) with FCE and CNV.Methods: The medi…
Leprosy and the Germ Theory
The germ theory of disease, one of the great accomplishments of science, was not established for two centuries after Anton van Leeuenhoek in 1674 saw microscopic, motile “animalcules” in stagnant pond water. These were relatively large single-celle…
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This Issue At A Glance
Tozer et al (p. 2029) evaluated the effectiveness of rescue therapy in eyes with neovascular age-related macular degeneration (AMD) that failed monotherapy with intravitreal injections of bevacizumab or ranibizumab. They found that the combination of …
Reply
Thank you very much, Dr. Khawaja Khalid Shoaib, for your interest in our article, Posterior Iris-claw Aphakic Intraocular Lens Implantation in Children. We agree with Dr. Shoaib regarding the rather short 31-month average follow-up in our study. The…
Author reply
Dear Editor: We thank Drs Bateman and Silva for their comments. We share their belief in the importance of genetic counseling and written documentation when caring for families affected with genetic diseases, which is why we included genetic counseli…
A Simple Vista en Este Número
Tozer y otros (p. 2029) evaluaron la efectividad de la terapia de rescate en ojos con degeneración macular neovascular relacionada con la edad (AMD) que no respondía a la monoterapia con inyecciones de bevacizumab o ranibizumab a intervalos. Determin…
Clinician-Scientists in Ophthalmology Revisited
Clinician-scientists play a vital role in ophthalmology in translating between clinical practice and discovery research. They transform their clinical observations into laboratory investigations and help to push their and others’ basic research toward …