We report a symptomatic patient who resembles the “salt and pepper endothelium” described by Hillenaar et al his “How Normal Is the Transparent Cornea? Effects of Ageing on Corneal Morphology.”
Category: Peer-reviewed
Author reply
We thank Hong et al for their interest in our paper “Shifting Trends in Bacterial Keratitis in Toronto, an 11 Year Review.” In our paper, we reviewed the microbiology records of 1701 consecutive corneal scrapings; our main findings were a significa…
Author reply
We thank Hong et al for their comments regarding our manuscript and would like to address several important issues that they raise. The focus of our paper was specifically to study keratoplasty among patients with corneal endothelial disease (CED). Exp…
Classification of Secondary Corneal Amyloidosis and Involvement of Lactoferrin – Corrected Proof
Purpose:
To classify secondary corneal amyloidosis (SCA) by its clinical appearance, to analyze the demographics of the patients, and to determine the involvement of lactoferrin.
Design:
Retrospective, observational, noncomparative, multicenter stu…
Enzymatic Detergents and Toxic Anterior Segment Syndrome
We read with interest the article by Leder et al entitled “An Investigation of Enzymatic Detergents as a Potential Cause of Toxic Anterior Segment Syndrome.” The authors investigated whether enzymatic detergents used in the cleaning of ophthalmic i…
Streptococcus Endophthalmitis Outbreak after Intravitreal Injection of Bevacizumab: One-Year Outcomes and Investigative Results – Corrected Proof
Purpose:
To report the 1-year clinical outcomes of an outbreak of Streptococcus endophthalmitis after intravitreal injection of bevacizumab, including visual acuity outcomes, microbiological testing, and compound pharmacy investigations by the Food a…
Infection Following Photorefractive Keratectomy
Photorefractive keratectomy (PRK) is the most commonly performed refractive procedure in the US military and is regaining popularity in the civilian world as a safe alternative to LASIK. Pain after PRK is often significant, but can be mediated with the…
Glaucoma Severity and Medication Adherence in a County Hospital Population – Corrected Proof
Objective:
To assess the association between disease severity and adherence with glaucoma medications in a county hospital population.
Design:
Cross-sectional study.
Participants:
A total of 126 patients diagnosed with glaucoma receiving intraocular pressure (IOP)–lowering medication were recruited from the San Francisco General Hospital Ophthalmology Clinic.
Methods:
Subjects completed an oral questionnaire to assess demographic information, knowledge of glaucoma, and perceptions of glaucoma medication adherence. Glaucoma disease severity was classified according to the American Academy of Ophthalmology’s Preferred Practice Pattern guidelines. Medication adherence was measured for each patient by obtaining pharmacy refill data and calculating medication possession ratio (MPR), that is, the ratio of total days’ supply of medication during a 365-day period. Adherence was measured retrospectively over the 18-month period before study entry. Subjects with an MPR >80% were considered adherent.
Main Outcome Measure:
Medication adherence.
Results:
Subjects with mild or moderate glaucoma were more likely to be nonadherent to their prescribed glaucoma medications than those with severe disease (adjusted odds ratio [OR], 1.54; 95% confidence interval [CI], 1.03–2.31; P = 0.04). Age, gender, race, education level, years of glaucoma, number of medications, and glaucoma diagnosis were not found to be statistically significantly associated with adherence.
Conclusion:
Patients with severe glaucoma were more likely to adhere to their topical IOP-lowering medication regimen than those with milder glaucomatous disease.
Financial Disclosure(s):
Proprietary or commercial disclosure may be found after the references.
Keratoplasty for Corneal Endothelial Disease
We read the article by Shtein et al on the rates of keratoplasty for corneal endothelial disease (CED) in a large cohort in the United States with interest. The researchers found that patients with CED had increased odds of undergoing keratoplasty in 2…
Ranibizumab Treatment Outcomes in Phakic versus Pseudophakic Eyes: An Individual Patient Data Analysis of 2 Phase 3 Trials – Corrected Proof
Objective:
To compare visual outcomes in phakic and pseudophakic eyes treated with monthly intravitreal ranibizumab for exudative age-related macular degeneration (AMD).
Design:
Meta-analysis of individual patient data from 2 phase 3 clinical trial…
Diagnostic Criteria for Primary Ocular Lymphoma
We describe a patient whose diagnosis and treatment of primary intraocular (PIOL) and central nervous system lymphoma (PCNSL) were delayed as a result of strict adherence to a diagnostic criterion of cytologic malignancy features of cells.
A Phenotype–Genotype Correlation Study of X-Linked Retinoschisis – Corrected Proof
Purpose:
To compare the clinical phenotype and detailed electroretinographic parameters in X-linked retinoschisis (XLRS).
Design:
Retrospective, comparative study.
Participants:
Fifty-seven patients (aged 1–67 years) with molecularly confirmed …
Author reply
The FDA acknowledges the extensive work performed by professional eye organizations, including the American Society of Cataract and Refractive Surgery (ASCRS), and Dr. Mamalis in combating Toxic Anterior Segment Syndrome (TASS) outbreaks.
Visual Outcome After Antioxidant Supplementation
In 2001, the National Eye Institute–funded Age-related Eye Disease Study (AREDS) published its findings. The AREDS was a double-masked, randomized, placebo-controlled trial of 4757 subjects over a period of 5 years that showed that supplementation wi…
Higher Prevalence of Myocilin Mutations in Advanced Glaucoma in Comparison with Less Advanced Disease in an Australasian Disease Registry – Corrected Proof
Objectives:
To determine the proportion of all Myocilin coding mutations responsible for advanced primary open-angle glaucoma (POAG) in early-age-at-onset individuals and to investigate the prevalence of exon 3 Myocilin mutations in advanced POAG at …
This Issue At A Glance
Although Descemet’s stripping endothelial keratoplasty (DSEK) is more expensive to perform compared to the traditional full-thickness penetrating keratoplasty (PK) for endothelial disease, Bose et al (p. 464) found that DSEK should be the preferred tre…
n-3 Fatty Acids and Retinal Function
Ageing is associated with progressive loss of retinal function characterized by altered rod and cone electroretinographic responses to light stimulation. n-3 long-chain polyunsaturated fatty acids (LCPs), especially eicosapentaenoic acid and docosahexa…
Choosing Wisely: Five Ideas that Physicians and Patients Can Discuss
In 2012, the American Academy of Ophthalmology joined 16 medical specialty societies in the second wave of the Choosing Wisely campaign, initiated by the American Board of Internal Medicine (ABIM) Foundation. Participating societies each created a list…
United States Food and Drug Administration TASS Program
I read with interest the article by Eydelman et al announcing the Food and Drug Administration’s (FDAs) proactive toxic anterior segment syndrome program, as well the accompanying editorial by Gottsch and Schein. The article and the editorial describe …
A Simple Vista en Este Número
Aunque la queratoplastia endotelial con denudamiento de la Descemet (DSEK) es más costosa que la queratoplastia penetrante (PK) de grosor completo tradicional para la enfermedad endotelial, Bose y otros (p. 464) determinaron que la DSEK debe ser la al…