Category: Peer-reviewed
Quantitative Evaluation of Drusen on Photographs
Visualizing and tracking drusen is important in managing age-related macular degeneration. Color fundus photography (CFP) is common in clinical practice, but quantitative evaluation of drusen in CFPs is difficult because of the varying background of th…
This Issue At A Glance
治疗角膜内皮疾病时, 角膜内皮移植手术 (DSEK) 相比传统的全层穿透性角膜移植术 (PK) 昂贵, 然而 Bose 等人 (p. 464) 发现, 从成本效益的角度看, DSEK 应是二者中的首选. 该研究举例, 假设给予固定
Author reply
We are pleased with the expressed interest in our work and appreciate the comments of Drs Mamalis and Edelhauser. This rabbit study was undertaken as part of the Food and Drug Administration’s Proactive Toxic Anterior Segment Syndrome (TASS) program to…
Erratum
With apologies from the publishers, the final authorship in the article entitled, “Prevalence of Glaucoma in a Rural Northern China Adult Population: A Population- based Survey in Kailu County, Inner Mongolia” by Wulian Song, MD, Li Shan, MD, Fang …
Editorial Board
Author reply
We appreciate the comments of Dr. Mamalis. We were unaware of the disagreements that the American Society of Cataract and Refractive Surgery (ASCRS) TASS force had with the Food and Drug Administration’s.
Bacterial Keratitis in Shanghai
The recent report by Lichtinger et al describing the clinical characteristics of bacterial keratitis isolates over a 11-year period within a Toronto institution raised our interest. Although we found several previous studies about the distribution, cur…
“Salt and Pepper” Corneal Endothelium
We report a symptomatic patient who resembles the “salt and pepper endothelium” described by Hillenaar et al his “How Normal Is the Transparent Cornea? Effects of Ageing on Corneal Morphology.”
Author reply
We thank Hong et al for their interest in our paper “Shifting Trends in Bacterial Keratitis in Toronto, an 11 Year Review.” In our paper, we reviewed the microbiology records of 1701 consecutive corneal scrapings; our main findings were a significa…
Author reply
We thank Hong et al for their comments regarding our manuscript and would like to address several important issues that they raise. The focus of our paper was specifically to study keratoplasty among patients with corneal endothelial disease (CED). Exp…
Classification of Secondary Corneal Amyloidosis and Involvement of Lactoferrin – Corrected Proof
Purpose:
To classify secondary corneal amyloidosis (SCA) by its clinical appearance, to analyze the demographics of the patients, and to determine the involvement of lactoferrin.
Design:
Retrospective, observational, noncomparative, multicenter stu…
Enzymatic Detergents and Toxic Anterior Segment Syndrome
We read with interest the article by Leder et al entitled “An Investigation of Enzymatic Detergents as a Potential Cause of Toxic Anterior Segment Syndrome.” The authors investigated whether enzymatic detergents used in the cleaning of ophthalmic i…
Streptococcus Endophthalmitis Outbreak after Intravitreal Injection of Bevacizumab: One-Year Outcomes and Investigative Results – Corrected Proof
Purpose:
To report the 1-year clinical outcomes of an outbreak of Streptococcus endophthalmitis after intravitreal injection of bevacizumab, including visual acuity outcomes, microbiological testing, and compound pharmacy investigations by the Food a…
Infection Following Photorefractive Keratectomy
Photorefractive keratectomy (PRK) is the most commonly performed refractive procedure in the US military and is regaining popularity in the civilian world as a safe alternative to LASIK. Pain after PRK is often significant, but can be mediated with the…
Glaucoma Severity and Medication Adherence in a County Hospital Population – Corrected Proof
Objective:
To assess the association between disease severity and adherence with glaucoma medications in a county hospital population.
Design:
Cross-sectional study.
Participants:
A total of 126 patients diagnosed with glaucoma receiving intraocular pressure (IOP)–lowering medication were recruited from the San Francisco General Hospital Ophthalmology Clinic.
Methods:
Subjects completed an oral questionnaire to assess demographic information, knowledge of glaucoma, and perceptions of glaucoma medication adherence. Glaucoma disease severity was classified according to the American Academy of Ophthalmology’s Preferred Practice Pattern guidelines. Medication adherence was measured for each patient by obtaining pharmacy refill data and calculating medication possession ratio (MPR), that is, the ratio of total days’ supply of medication during a 365-day period. Adherence was measured retrospectively over the 18-month period before study entry. Subjects with an MPR >80% were considered adherent.
Main Outcome Measure:
Medication adherence.
Results:
Subjects with mild or moderate glaucoma were more likely to be nonadherent to their prescribed glaucoma medications than those with severe disease (adjusted odds ratio [OR], 1.54; 95% confidence interval [CI], 1.03–2.31; P = 0.04). Age, gender, race, education level, years of glaucoma, number of medications, and glaucoma diagnosis were not found to be statistically significantly associated with adherence.
Conclusion:
Patients with severe glaucoma were more likely to adhere to their topical IOP-lowering medication regimen than those with milder glaucomatous disease.
Financial Disclosure(s):
Proprietary or commercial disclosure may be found after the references.
Keratoplasty for Corneal Endothelial Disease
We read the article by Shtein et al on the rates of keratoplasty for corneal endothelial disease (CED) in a large cohort in the United States with interest. The researchers found that patients with CED had increased odds of undergoing keratoplasty in 2…
Ranibizumab Treatment Outcomes in Phakic versus Pseudophakic Eyes: An Individual Patient Data Analysis of 2 Phase 3 Trials – Corrected Proof
Objective:
To compare visual outcomes in phakic and pseudophakic eyes treated with monthly intravitreal ranibizumab for exudative age-related macular degeneration (AMD).
Design:
Meta-analysis of individual patient data from 2 phase 3 clinical trial…
Diagnostic Criteria for Primary Ocular Lymphoma
We describe a patient whose diagnosis and treatment of primary intraocular (PIOL) and central nervous system lymphoma (PCNSL) were delayed as a result of strict adherence to a diagnostic criterion of cytologic malignancy features of cells.
A Phenotype–Genotype Correlation Study of X-Linked Retinoschisis – Corrected Proof
Purpose:
To compare the clinical phenotype and detailed electroretinographic parameters in X-linked retinoschisis (XLRS).
Design:
Retrospective, comparative study.
Participants:
Fifty-seven patients (aged 1–67 years) with molecularly confirmed …