Month: January 2013

OCT may detect pre-perimetric changes in glaucomatous eyes

WAIKOLOA, Hawaii — Optic nerve head microcirculation is reduced in glaucoma patients, a speaker said here.“Conventionally, OCT is used to measure structure with micron precision, and that has been very useful in terms of characterizing the structure of the optic nerve head, the nerve fiber layer and the ganglion cell complex,” David Huang, MD, PhD, said at Hawaiian Eye 2013. “We developed a technique where we decomposed the OCT image into several spectral bands and analyzed them separately and recombined them to enhance a signal of flow.”

Goniotomy, trabeculotomy produce most successful results in pediatric glaucoma

WAIKOLOA, Hawaii — Goniotomy and trabeculotomy are the most effective surgical methods for infantile glaucoma, a speaker said here.“The first thing that’s most important in these surgeries is visualization,” Ken K. Nischal, MD, FRCOphth, said at Hawaiian Eye 2013. “It’s really important to understand that the goniolens you use will affect how easy or how difficult the procedure becomes.”

Diagnostic vitrectomy for uveitis indicated to obtain tissue for biopsy

WAIKOLOA, Hawaii — The need for a biopsy specimen in a patient with uveitis is an indication for diagnostic vitrectomy, a somewhat technique-based but mostly disease-based procedure, according to a speaker.“Figuring out the disease and what you need to do to control it is an essential part of the surgery, because the disease, in many cases, is going to be ongoing even after the surgical procedure,” Janet L. Davis, MD, told colleagues at Retina 2013.

Small globe size, high concentration of VEGF in vitreous may be risk factor for early AMD

HYDERABAD, India — Small globe size, possibly in correlation with a thicker vitreous and a higher concentration of VEGF, may be a major risk factor for early age-related macular degeneration, according to a speaker here. “In the Beijing Eye Study, hyperopia, short interscleral spur distance and small optic disc size, besides older age, were found to be the main risk factors associated with early AMD. This points to a small globe size, and we may speculate that the vitreous plays a role,” Jost B. Jonas, MD, said at the joint (Read more...)

Precut corneal tissue offers better safety, quality assurance

HYDERABAD, India — Corneal tissue precut by an eye bank provides better safety and quality assurance despite some disadvantages, according to a speaker here. “Precut tissue entails higher costs, needs swelling and a time interval of over 24 hours before transplantation. On the other hand, it is thoroughly examined and analyzed by slit lamp and specular microscopy. Only the best and safest lenticules are used in the OR,” Howard Cajucom-Uy, MD, said at the joint meeting of the Asia-Pacific Academy of Ophthalmology and All India Ophthalmological Society.

Spectral-Domain Optical Coherence Tomographic Assessment of Schlemm’s Canal in Chinese Subjects with Primary Open-angle Glaucoma

Purpose:
To evaluate in vivo features of Schlemm’s canal (SC) in patients with primary open-angle glaucoma (POAG) with spectral-domain optical coherence tomography (SD-OCT) and to investigate the relationship of SC size with intraocular pressure (IOP) and glaucoma severity.

Design:
Prospective, comparative study.

Participants:
Fifty Chinese patients with newly diagnosed POAG who had not undergone surgery and 50 normal Chinese subjects from a population-based, cross-sectional study in Shanghai.

Methods:
All participants underwent SD-OCT. The diameter and area of SC were examined in the temporal and nasal sections and measured with customized (Read more...)

Comparison of Clinical Characteristics Between Korean and Western Normal-Tension Glaucoma Patients – Corrected Proof

Purpose: To detect potential differences in the phenotypes between Western normal-tension glaucoma (NTG) and Korean NTG.Design: A retrospective, cross-sectional study.Methods: One hundred eighty-four NTG eyes of 71 patients of the Jules Stein Eye Institute, University of California, Los Angeles, and 113 patients of the Seoul National University Hospital, Seoul, Korea, were studied after reviewing medical charts retrospectively. All eligible patients from both institutions who were evaluated between July 2007 and June 2008 were included. The groups were matched for stage of glaucoma severity based on the visual field mean deviation value. All patients underwent a complete ophthalmic examination, Humphrey perimetry, Heidelberg Retina (Read more...)

High-Resolution Imaging of Retinal Nerve Fiber Bundles in Glaucoma Using Adaptive Optics Scanning Laser Ophthalmoscopy – Corrected Proof

Purpose: To detect pathologic changes in retinal nerve fiber bundles in glaucomatous eyes seen on images obtained by adaptive optics (AO) scanning laser ophthalmoscopy (AO SLO).Design: Prospective cross-sectional study.Methods: Twenty-eight eyes of 28 patients with open-angle glaucoma and 21 normal eyes of 21 volunteer subjects underwent a full ophthalmologic examination, visual field testing using a Humphrey Field Analyzer, fundus photography, red-free SLO imaging, spectral-domain optical coherence tomography, and imaging with an original prototype AO SLO system.Results: The AO SLO images showed many hyperreflective bundles suggesting nerve fiber bundles. In glaucomatous eyes, the nerve fiber bundles were narrower than in normal (Read more...)

Angiographic and Optical Coherence Tomography Characteristics of Recent Myopic Choroidal Neovascularization – Corrected Proof

Purpose: To analyze the contribution of fluorescein angiography (FA) and spectral-domain optical coherence tomography (SD OCT) to the diagnosis of recent choroidal neovascularization (CNV) associated with high myopia.Design: Retrospective, observational case series.Methods: Ninety eyes of 73 highly myopic patients (refractive error ≥−6 diopters) with CNV in 1 or both eyes were included. Epidemiologic features, refractive error, fundus examination, fluorescein angiography, and SD OCT findings at onset of CNV were analyzed.Results: Mean age at onset of CNV was 54.4 ± 14 years. CNV was bilateral in 17 of 73 cases. Mean refractive error was −13.9 ± 5.2 diopters. Myopic CNV was associated (Read more...)

Use of Corneal Power-Specific Constants to Improve the Accuracy of the SRK/T Formula

Purpose:
To evaluate the effect of average corneal power (K) and axial length (AL) in a data-adjusted A-constant for improving the refractive outcome in the Sanders–Retzlaff–Kraff (SRK)/T formula.

Design:
Retrospective, consecutive, case series.

Participants:
A total of 637 patients (637 eyes) who underwent uncomplicated phacoemulsification with implantation of the Acrysof IQ (IQ; Alcon, Fort Worth, TX; 314 eyes) or Akreos AO (AO; Bausch & Lomb, Rochester, NY; 323 eyes) intraocular lens (IOL) by a single surgeon.

Methods:
The correlation among the K, AL, and predicted refractive error in the SRK/T (Read more...)