Author: Ophthalmology

Intravitreal Bevacizumab at 4-Month Intervals for Prevention of Macular Edema after Plaque Radiotherapy of Uveal Melanoma – Corrected Proof

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Purpose: To evaluate the efficacy of intravitreal bevacizumab for prevention of macular edema after plaque radiotherapy of uveal melanoma.Design: Retrospective, single-center, nonrandomized, interventional comparative study.Participants: Patients with uveal melanoma treated with plaque radiotherapy were divided into 2 groups: a bevacizumab group and a control group.Intervention: The bevacizumab group received intravitreal bevacizumab injection at the time of plaque removal and every 4 months thereafter for 2 years (total, 7 injections). The control group had no intravitreal bevacizumab injection. Both groups had periodic follow-up with ophthalmoscopy and optical coherence tomography (OCT).Main Outcome Measures: Development of OCT-evident macular edema.Results: There were 292 patients (Read more...)

The United Kingdom Glaucoma Treatment Study: A Multicenter, Randomized, Double-masked, Placebo-controlled Trial: Baseline Characteristics – Corrected Proof

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Objective: The United Kingdom Glaucoma Treatment Study (UKGTS) tests the hypothesis that treatment with a topical prostaglandin analog, compared with placebo, reduces the frequency of visual field (VF) deterioration events in patients with open-angle glaucoma (OAG) by 50% over a 2-year period. Additional goals are to evaluate study power with novel clinical trial outcomes: (1) VF deterioration velocity and (2) VF and quantitative imaging measurements modeled as joint outcomes.Design: The UKGTS is a randomized, double-masked, placebo-controlled, multicenter treatment trial for OAG.Participants: A total of 516 patients with newly diagnosed (previously untreated) OAG were prospectively recruited at 10 UK centers between (Read more...)

Imaging of the Macula Indicates Early Completion of Structural Deficit in Autosomal-Dominant Optic Atrophy – Corrected Proof

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Purpose: Optical coherence tomography (OCT) enables 3-dimensional imaging of the retina, including the layer of ganglion cells that supplies the optic nerve with its axons. We tested OCT as means of diagnosing and phenotyping autosomal-dominant optic atrophy (ADOA).Design: Cross-sectional study.Participants: The study included 49 patients with OPA1 exon 28 (2826delT) ADOA (age, 8.6–71.5 years; best-corrected visual acuity [BCVA], 20/700–20/20) and 51 mutation-free first-degree relatives as healthy controls (BCVA 20/25–20/10).Methods: Participants underwent routine examination, including automated perimetry, and OCT with segmentation of the perifoveal retinal ganglion cell–inner plexiform layer (GC-IPL) and the peripapillary retinal nerve fiber layer (RNFL).Main Outcome Measures: Perifoveal (Read more...)

Assessing the Effectiveness of Surface Cleaning Methods in Intravitreal Injection Procedure Rooms – Corrected Proof

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Purpose: To assess cleaning effectiveness of room surfaces in an office-based intravitreal injection practice by using adenosine triphosphate (ATP) luminometry.Design: Prospective, comparative case series.Participants: A total of 792 intravitreal injection room surfaces were sampled (396 before cleaning, 396 after cleaning) using 3 cleaning methods.Methods: Three cleaning methods were evaluated: baseline terminal cleaning, directed terminal cleaning, and enhanced terminal cleaning. For each method, residual ATP bioburden (relative light units [RLUs]/sample) was sampled from 9 high-touch injection room surfaces before and after terminal cleaning using the 3M Clean-Trace ATP System (3M Inc, St. Paul, MN). Surface ATP RLUs were used to compare (Read more...)

AAO Task Force on Genetic Testing

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In this era of rapidly expanding genetic medicine, the American Academy of Ophthalmology (AAO)’s recently published document of recommendations for genetic testing of inherited eye diseases comes none too soon. Guidelines for genetic testing are import…

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