Objective: To determine long-term outcomes of patients with ranibizumab-treated retinal vein occlusion (RVO).Design: Prospective follow-up of a subset of patients from 2 phase 3 trials.Participants: Thirty-four patients with branch RVO (BRVO) and 32 wi…
Category: Peer-reviewed
Visual and Refractive Outcomes of Femtosecond Lenticule Extraction and Small-Incision Lenticule Extraction for Myopia – Corrected Proof
Purpose: To compare the visual and refractive outcomes of femtosecond lenticule extraction (FLEx) and small-incision lenticule extraction (SMILE) in eyes with myopia.Design: Prospective, randomized, masked clinical trial with intraindividual comparison…
Eyelid Sebaceous Carcinoma: Clinicopathologic and Multiparametric Immunohistochemical Analysis That Includes Adipophilin – Corrected Proof
Purpose: To evaluate the fine cytopathologic features and immunohistochemistry of eyelid sebaceous carcinoma.Design: Retrospective clinicopathologic study.Methods: Clinical records and microscopic glass slides of 12 patients diagnosed with sebaceous ca…
Randomized Controlled Trial of Intravitreal Ranibizumab Versus Standard Grid Laser for Macular Edema Following Branch Retinal Vein Occlusion – Corrected Proof
Purpose: To assess the efficacy of intravitreal 0.5 mg ranibizumab for the treatment of center-involving macular edema secondary to branch retinal vein occlusion (BRVO) over 1 year compared with standard-of-care grid laser.Design: A prospective random…
Three-Year Incidence and Factors Associated With Posterior Capsule Opacification After Cataract Surgery: The Australian Prospective Cataract Surgery and Age-related Macular Degeneration Study – Corrected Proof
Purpose: To assess 3-year incidence and associated factors of posterior capsule opacification (PCO) after phacoemulsification surgery.Design: Cohort study.Methods: A total of 1934 consecutive patients aged ≥64 years undergoing phacoemulsification sur…
Evaluation of Levator Function for Efficacy of Minimally Invasive and Standard Techniques for Involutional Ptosis – Corrected Proof
Purpose: To evaluate clinical and anatomic outcomes of surgery for involutional ptosis using standard-length or small incisions in relation to preoperative levator function.Design: Retrospective study.Methods: Sixty-three patients diagnosed with involutional ptosis who underwent surgical correction using a small or standard-length incision between November 2010 and December 2011 were reviewed; a single surgeon performed surgery using a small incision (8 to 10 mm) in 22 patients and a standard-length incision (20 to 22 mm) in 34 patients. All patients underwent standard preoperative ptosis evaluation with margin-to-reflex distance 1 and 2 measurements and levator function assessment. Patients were divided into 2 groups according to levator function (moderate: 5 to 10 mm; and good: >10 mm). Surgical success was evaluated based on the British Oculoplastic Surgery Society criteria.Results: Of 83 upper eyelids of 63 patients, surgery was performed using a small incision in 40 and a standard incision in 43. In patients with good levator function, surgical success was achieved with a small incision in 18 eyelids (94.7%) and a standard incision in 20 eyelids (95.2%; P = .91). In patients with moderate levator function, surgical success was achieved with a small incision in 14 eyelids (66.7%) and with a standard incision in 18 eyelids (81.8%; P = .04).Conclusions: These findings indicate a similar surgical success rate in patients with good levator function, regardless of incision length. The surgical success rate in patients with moderate levator function was lower when using a small incision, perhaps because of decreased visualization and anatomic access.
Epidemiology and Disease Burden of Pathologic Myopia and Myopic Choroidal Neovascularization: An Evidence-Based Systematic Review – Corrected Proof
Purpose: To summarize the epidemiology of pathologic myopia and myopic choroidal neovascularization (CNV) and their impact on vision.Design: Systematic literature review of all English-language studies evaluating the epidemiology and visual burden of p…
Intraocular Lens Power Calculation by Ray-Tracing after Myopic Excimer Laser Surgery – Corrected Proof
Purpose: To investigate the refractive outcomes of intraocular lens (IOL) power calculation by ray-tracing after myopic excimer laser surgery.Design: Prospective, interventional case series.Methods: setting: Multicenter study. participants: Twenty-one …
KRT12 Mutations and In Vivo Confocal Microscopy in Two Japanese Families With Meesmann Corneal Dystrophy – Corrected Proof
Purpose: To identify genetic mutations and study the corneal epithelium in Japanese patients with Meesmann corneal dystrophy.Design: Laboratory investigation and prospective observational case series.Methods: Slit-lamp biomicroscopy with fluorescein vi…
Metamorphopsia and Optical Coherence Tomography Findings After Rhegmatogenous Retinal Detachment Surgery – Corrected Proof
Purpose: To investigate the relationship between metamorphopsia and macular morphologic changes after successful repair of rhegmatogenous retinal detachment (RD).Design: Prospective, interventional, consecutive study.Methods: The study included 129 eyes of 129 patients who had undergone successful retinal reattachment surgery. The severity of metamorphopsia was recorded using M-CHARTS and foveal microstructure was assessed with spectral-domain optical coherence tomography (OCT) at 6-12 months postoperatively.Results: The mean metamorphopsia score was 0.30 ± 0.46, and 50 of 129 patients (39%) had metamorphopsia. Metamorphopsia was more severe in eyes with macula-off rhegmatogenous RD than those with macula-on (P < .001). Eighteen of 50 eyes with metamorphopsia exhibited abnormal structures in the macular region (epiretinal membrane, disruption of the photoreceptor inner and outer segment junction, cystoid macular edema, macular hole, or subretinal fluid), whereas the other 32 eyes showed no morphologic changes with OCT. In these 32 eyes, the horizontal metamorphopsia score (0.86 ± 0.50) was significantly higher than the vertical metamorphopsia score (0.62 ± 0.39, P < .05). Nine of 69 eyes with preoperative macula-on rhegmatogenous RD developed postoperative metamorphopsia. Of the 9 eyes, 6 showed abnormal macular structures and the other 3 had normal-appearing OCT. The macula briefly detached during vitrectomy in these 3 cases.Conclusions: In eyes that remained macula-on throughout surgery and had normal-appearing OCT, metamorphopsia did not develop. In some cases, the reason for metamorphopsia was anatomically obvious. In other cases that were preoperative and intraoperative macula-off, postoperative retinal vertical displacement could cause predominantly horizontal metamorphopsia.
Using human induced pluripotent stem cells to treat retinal disease
Publication date: Available online 6 October 2013 Source:Progress in Retinal and Eye Research Author(s): S. Borooah , M.J. Phillips , B. Bilican , A.F. Wright , I. Wilmut , S. Chandran , D. Gamm , B. Dhillon The eye is an ideal…
Focal Choroidal Excavation Complicated by Choroidal Neovascularization – Corrected Proof
Purpose: To evaluate the clinical findings of focal choroidal excavation (FCE) complicated by choroidal neovascularization (CNV).Design: Retrospective, observational case series.Participants: Twelve patients (15 eyes) with FCE and CNV.Methods: The medi…
Editorial Board
Posterior Iris-claw Aphakic Intraocular Lens Implantation in Children
Posterior Iris-claw Aphakic Intraocular Lens Implantation in Children is an interesting article. The authors have rightly pointed out that many complications of anterior iris claw aphakic intraocular lenses (IOL) are avoided. However, potentially the m…
Clear Lens Extraction for Angle Closure
We read with great interest the recent article by Tham et al. In their prospective study, the authors compared the results of clear lens phacoemulsification (CLP) versus trabeculectomy with mitomycin C in eyes with medically uncontrolled chronic angle…
Long-term Outcomes in Ranibizumab-Treated Patients With Retinal Vein Occlusion; The Role of Progression of Retinal Nonperfusion
Purpose: To determine the percentage of ranibizumab-treated patients with retinal vein occlusion (RVO) who had resolution of edema for at least 6 months after the last injection, along with factors and outcomes that correlate with resolution.Design: Post hoc analysis of open-label clinical trial.Methods: Twenty patients with branch RVO (BRVO) and 20 with central RVO (CRVO) received ranibizumab monthly for 3 months and as needed for recurrent/persistent macular edema, no more frequently than every 2 months. Patients still requiring injections after month 40 received scatter and grid laser photocoagulation to try to reduce the need for injections. Main outcome measures included the percentage of patients who had resolution of edema, change in best-corrected visual acuity (BCVA) from baseline, and change in area of retinal nonperfusion in central subfields.Results: Nine patients with BRVO (45%) had edema resolution from injections alone after a mean of 20.2 months, 4 resolved after addition of laser, 4 were unresolved through 72 months, and 3 exited prior to resolution. Five patients with CRVO (25%) resolved from injections alone after a mean of 14.0 months, 8 remained unresolved through 72 months despite addition of laser, and 7 exited prior to resolution. For BRVO or CRVO, there was a negative correlation between posterior retinal nonperfusion area and BCVA at months 18, 24, and 36 (P < .05).Conclusions: In patients with RVO, infrequent ranibizumab injections to control edema may not be sufficient to prevent progression of retinal nonperfusion, which may contribute to loss of visual gains.
AAO Task Force on Genetic Testing
In this era of rapidly expanding genetic medicine, the American Academy of Ophthalmology (AAO)’s recently published document of recommendations for genetic testing of inherited eye diseases comes none too soon. Guidelines for genetic testing are import…
Reporting Visual Acuities
The AJO encourages authors to report the visual acuity in the manuscript using the same nomenclature that was used in gathering the data provided they were recorded in one of the methods listed here. This table of equivalent visual acuities is provided…
Author reply
We are grateful to Spratt et al for their interest in our article, and for allowing us the opportunity to further elaborate on our study. We did observe an apparent decrease in the perceived extent of peripheral anterior synechiae (PAS) after lens e…
Reply
We appreciate the thoughtful comments of Rath and associates and agree with their assessment of the limitations of our study. We intended to examine the diagnostic yield and therapeutic benefit of nonquantitative polymerase chain reaction (PCR) in the …