Publication date: Available online 9 January 2014
Source:Progress in Retinal and Eye Research
Author(s): M. Maenz , D. Schlüter , O. Liesenfeld , G. Schares , U. Gross , U. Pleyer
Ocular toxoplasmosis (OT) is considered the most frequent form of infectious posterior uveitis and is caused by the (Read more...)
Category: Peer-reviewed
Müller glia: stem cells for generation and regeneration of retinal neurons in teleost fish
Publication date: Available online 8 January 2014
Source:Progress in Retinal and Eye Research
Author(s): Jenny R. Lenkowski , Pamela A. Raymond
Adult zebrafish generate new neurons in the brain and retina throughout life. Growth-related neurogenesis allows a vigorous regenerative response to damage, and fish can regenerate retinal neurons, including (Read more...)
Cost-Effectiveness of Bevacizumab and Ranibizumab for Newly Diagnosed Neovascular Macular Degeneration – Corrected Proof
Purpose: We sought to determine the most cost-effective treatment for patients with newly diagnosed neovascular macular degeneration: monthly or as-needed bevacizumab injections, or monthly or as-needed ranibizumab injections.Design: Cost-effectiveness analysis.Participants: Hypothetical cohort of 80-year-old patients with newly diagnosed neovascular macular degeneration.Methods: Using a mathematical model with a 20-year time horizon, we compared the incremental cost-effectiveness of treating a hypothetical cohort of 80-year-old patients with newly diagnosed neovascular macular degeneration using monthly bevacizumab, as-needed bevacizumab, monthly ranibizumab, or as-needed ranibizumab. Data came from the Comparison of Age-related macular degeneration Treatment Trial (CATT), the Medicare Fee Schedule, and the medical literature.Main Outcome (Read more...)
Assessment of Iris Surface Features and Their Relationship with Iris Thickness in Asian Eyes – Corrected Proof
Purpose: To assess iris surface features in Asian eyes and examine their associations with iris thickness measured by anterior segment optical coherence tomography (AS OCT).Design: Cross-sectional study.Participants: We recruited 250 subjects from the Singapore Malay Eye Study.Methods: We obtained standardized slit-lamp photographs and developed a grading system assessing iris crypts (by number and size), furrows (by number and circumferential extent), and color (higher grade denoting darker iris). Vertical and horizontal cross-sections of the anterior chamber were imaged using AS OCT. Intragrader and intergrader agreements in the grading of iris surface were assessed by weighted κ (κw) statistic. Associations of the (Read more...)
Proton Therapy for Uveal Melanoma in 43 Juvenile Patients: Long-Term Results – Corrected Proof
Purpose: To examine the metastatic and survival rates, eye retention probability, and the visual outcomes of juvenile patients after proton beam radiotherapy (PBRT) for uveal melanoma (UM).Design: Retrospective case-factor matched control study.Participants and Controls: Forty-three patients younger than 21 years treated with PBRT for UM were compared with 129 matched adult control patients.Methods: Information on patient demographics and clinical characteristics were recorded before and after treatment from patients’ files. The control group was composed of adult patients (>21 years) matched for tumor size (largest tumor diameter, ±2 mm; height, ±2 mm) and anterior margin location (iris, ciliary body, pre-equatorial or (Read more...)
A Randomized, Controlled Trial of Corneal Collagen Cross-Linking in Progressive Keratoconus: Three-Year Results – Corrected Proof
Purpose: To report the refractive, topographic, and clinical outcomes 3 years after corneal collagen cross-linking (CXL) in eyes with progressive keratoconus.Design: Prospective, randomized controlled trial.Participants: One hundred eyes with progressive keratoconus were randomized into the CXL treatment or control groups.Methods: Cross-linking was performed by instilling riboflavin 0.1% solution containing 20% dextran for 15 minutes before and during the 30 minutes of ultraviolet A irradiation (3 mW/cm2). Follow-up examinations were arranged at 3, 6, 12, 24, and 36 months.Main Outcome Measures: The primary outcome measure was the maximum simulated keratometry value (Kmax). Other outcome measures were uncorrected visual acuity (UCVA; measured (Read more...)
Genes in the High-Density Lipoprotein Metabolic Pathway in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy – Corrected Proof
Purpose: To investigate the associations of genetic variants in the high-density lipoprotein (HDL) metabolism pathway with neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV).Design: Cross-sectional, case-cont…
Diagnostic Performance of Optical Coherence Tomography Ganglion Cell–Inner Plexiform Layer Thickness Measurements in Early Glaucoma – Corrected Proof
Purpose: To evaluate the glaucoma diagnostic performance of ganglion cell inner–plexiform layer (GCIPL) parameters used individually and in combination with retinal nerve fiber layer (RNFL) or optic nerve head (ONH) parameters measured with Cirrus HD…
Intraocular Pressure in Eyes Receiving Monthly Ranibizumab in 2 Pivotal Age-Related Macular Degeneration Clinical Trials – Corrected Proof
Purpose: To characterize preinjection intraocular pressure (IOP) in eyes receiving monthly ranibizumab versus sham or verteporfin photodynamic therapy (PDT) for age-related macular degeneration (AMD).Design: Post hoc analysis of IOP data from 2 phase 3 clinical trials, the Minimally Classic/Occult Trial of the Anti-VEGF Antibody Ranibizumab in the Treatment of Neovascular AMD (MARINA) and the Anti-VEGF Antibody for the Treatment of Predominantly Classic Choroidal Neovascularization in AMD (ANCHOR) trial.Participants: All safety-evaluable patients who received 1 or more injections of sham or PDT or of ranibizumab and had 1 or more postbaseline IOP measurements recorded for the study eye.Methods: Preinjection IOP measurements (Read more...)
Trimethoprim-sulfamethoxazole versus placebo to reduce the risk of recurrences of toxoplasma gondii retinochoroiditis: randomized controlled clinical trial – Accepted Manuscript
Abstract: Purpose: To compare the effects of trimethoprim-sulfamethoxazole versus placebo in reducing the risk of recurrences of toxoplasma gondii retinochoroiditis.Design: Single-center, prospective randomized, double-masked, clinical trial.Methods: A…
Ultrasound biomicroscopy in chronic pseudophakic ocular inflammation associated with misplaced intraocular lens haptics – Accepted Manuscript
Abstract: Purpose: To evaluate the usefulness of ultrasound biomicroscopy in confirming intraocular lens haptic-induced ocular irritation and in the management of these patients.Design: A retrospective review of patient data.Methods: Twenty pseudophaki…
The role of low intracranial pressure in the development of glaucoma in patients with Alzheimer’s disease
Publication date: Available online 4 January 2014 Source:Progress in Retinal and Eye Research Author(s): Peter Wostyn , Veva De Groot , Debby Van Dam , Kurt Audenaert , Peter Paul De Deyn
Dry Eye in the Beaver Dam Offspring Study: Prevalence, Risk Factors, and Health-Related Quality of Life – Accepted Manuscript
Abstract: Purpose: To estimate dry eye prevalence in the Beaver Dam Offspring Study (BOSS), including a young adult population, and investigate associated risk factors and impact on health-related quality of life.Design: Cohort study.Methods: The BOSS (2005-2008) is a study of aging in the adult offspring of the population-based Epidemiology of Hearing Loss Study cohort. Questionnaire data on health history, medication use, risk factors, and quality of life were available for 3275 participants. Dry eye was determined by self-report of frequency of symptoms and the intensity of those symptoms. Associations between dry eye and risk factors were analyzed using logistic regression.Results: (Read more...)
Corneal biomechanics as a function of intraocular pressure and pachymetry by Dynamic Infrared Signal and Scheimpflug Imaging Analysis in normal eyes – Accepted Manuscript
Abstract: Purpose: To evaluate corneal biomechanical deformation response using Ocular Response Analyzer (ORA) and Corvis ST data.Design: Prospective Observational case control studyMethods: 1262 eyes of 795 patients were enrolled. 3 groups were established, according to the corneal compensated intraocular pressure (IOPcc), group I (10-13mmHg), group II (14-17mmHg), and group III (18-21mmHg). Each group included 3 subgroups, based on central corneal thickness (CCT), subgroup 1 (465-510㎛), 2 (510-555㎛), and 3 (555-600㎛). In addition, similar groups of CCT were divided into subgroups of IOPcc. Corneal hysteresis (CH) and corneal resistance factor (CRF) were derived from ORA. The parameters of highest concavity with (Read more...)
Vitreoretinal Management and Surgical Outcomes in Proliferative Sickle Retinopathy: A Case Series – Accepted Manuscript
Abstract: Purpose: To report the outcomes of current vitreoretinal surgical management of proliferative sickle retinopathy and to compare current methods to previous studies.Design: A retrospective, interventional case series.Methods: Fifteen eyes of 1…
Impact of Cylinder Axis on the Treatment for Astigmatic Amblyopia – Accepted Manuscript
Abstract: Purpose: To compare the effects of oblique astigmatism on refractive amblyopia in children aged 3–7 years with those having orthogonal astigmatism.Design: A retrospective review of medical records.Methods: The medical records of patients attending Tri-Service General Hospital in Taiwan from January 2003 to December 2010 were reviewed and summarized. Seventy-two children with oblique astigmatism-related refractive amblyopia (group 1) and 82 children with orthogonal astigmatism (group 2) were chosen. Characteristics such as baseline visual acuity (VA), the time course of VA improvement, refractive error, and family history were assessed.Results: Group 1 showed a worse baseline mean VA (± SD) of 0.61 (Read more...)
Clinical Utilization of Anti-VEGF Agents and Disease Monitoring in Neovascular Age-Related Macular Degeneration – Accepted Manuscript
Abstract: Purpose: To examine bevacizumab and ranibizumab utilization and disease monitoring patterns in patients with neovascular age-related macular degeneration (neovascular AMD) in clinical practice.Design: Retrospective medical claims analysis.Met…
期刊一览
Shah (p. 352) 等人分析了肺癌葡萄膜转移患者的临床特征、治疗及预后。 他们发现，44%葡萄膜转移癌患者在转移灶发现时并未诊断出肺癌。另外，他们还发现，尽管现阶段的眼部治疗方案可以尽…
This Issue At A Glance
Shah et al (p. 352) assessed the clinical features, treatment, and prognosis of patients with uveal metastasis from lung cancer. They found that 44% of patients with uveal metastasis had not been diagnosed with lung cancer at the time the metastasis w…
A Simple Vista en Este Número
Shah y otros (p. 352) evaluaron las características, el tratamiento y el pronóstico clínico de pacientes con metástasis uveal por cáncer de pulmón. Encontraron que 44% de los pacientes con metástasis uveal no habían sido diagnosticados con cán…